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Biography

John Mansour, M.D., is an Associate Professor in the Department of Surgery and Chief of Surgical Oncology at UT Southwestern Medical Center. He also serves as leader of the Gastrointestinal Cancer Disease-Oriented Team at Harold C. Simmons Comprehensive Cancer Center. He treats patients with malignancies of the stomach, pancreas, liver, bile duct, and other abdominal organs, as well as the diverse population of sarcoma patients.

A Cleveland native, Dr. Mansour earned his medical degree at Case Western Reserve University, and he completed a residency in surgery at the University of Wisconsin Hospital and Clinics. He then received advanced training in surgical oncology and upper GI and hepatopancreatobiliary malignancy through a fellowship at Memorial Sloan Kettering Cancer Center.

Board-certified in surgery by the American College of Surgeons, he joined UT Southwestern in 2007. 

Dr. Mansour conducts research on the genetic analysis of tumors and blood in order to predict a tumor’s behavior, how aggressive it will be, and how well patients will tolerate a major operation. He is also part of a national team that measures how well doctors and hospitals are caring for patients with hepatobiliary cancers.

Dr. Mansour has been a guest lecturer at international, national, regional, and local medical conferences. His research has been published in numerous medical journals, including the Annals of Surgical Oncology and Journal of the American College of Surgeons. He is an ad hoc reviewer for the Journal of Surgical Oncology, Annals of Surgery, HPB Journal, Archives of Surgery, and Journal of the American College of Surgeons.

He is a member of the American Society of Clinical Oncology, the Association for Academic Surgery, the Americas Hepato-Pancreato-Biliary Association, and the Society of Surgical Oncology.

Dr. Mansour was included in D Magazine's Best Doctors list for 2018.

Personal Note

Dr. Mansour likes spending time with his family and working out at the gym. He also enjoys reading biographies and cheering on his beloved Notre Dame Fighting Irish.

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Meet Dr. Mansour

Surgical Oncologist

John Mansour, M.D., Chief of the Division of Surgical Oncology at UT Southwestern Medical Center, combines the skills of a surgeon, a scientist, and a patient care advocate to offer his patients the total package in cancer care.

He treats patients with malignancies of the stomach, pancreas, liver, bile duct, and other abdominal organs. He says that treating these cancers requires bringing your “A” game every single day.

“To be a good surgical oncologist, you can’t be just one thing,” Dr. Mansour says. “You have to be a skilled surgeon and a scientist who understands what the next steps in cancer care are five, 10, 20 years down the line. You have to be an oncologist who understands cancer, chemotherapy, radiation therapy, and other therapies. And you need personal skills to bring together all of those pieces with a patient and his or her family, which is not always easy to do.”

Empowering Patients

Dr. Mansour likes taking care of people who have complex diseases, and he believes that UT Southwestern is a great community and regional resource for difficult problems such as stomach cancer, pancreatic cancer, liver cancer, and sarcomas.

“Other surgeons might see these challenging kinds of issues once a year or even once in their career. Our group sees these problems every week,” he says.

Dr. Mansour’s patients leave his office with two things: hope and a plan. He welcomes questions and also encourages his patients to learn as much about their condition as possible.

"I want my patients to be mini experts in their disease so they understand not just what I’m recommending but why I’m recommending it to them,” he says. “They’re making very big decisions, and I believe in keeping them informed."

Crafting the Future of Cancer Care

As leader of the Gastrointestinal Cancer Disease-Oriented Team at Harold C. Simmons Comprehensive Cancer Center, Dr. Mansour oversees the clinical, research, and educational activities of all UT Southwestern gastrointestinal (GI) cancer programs. He’s also part of a national team that measures how well doctors and hospitals are caring for patients with hepatobiliary cancers.

Passionate about quality care, Dr. Mansour anticipates that the cutting-edge research being done today at UT Southwestern will allow doctors to treat cancers differently in the future. His own research focuses on genetic analysis of tumors and blood in order to better predict a particular tumor’s behavior, how aggressive it will be, and how well patients will tolerate a major operation.

He believes that such an individualized approach will revolutionize cancer care and make cancer much easier to treat. “I anticipate that we will develop individualized treatment for each patient that will help them live longer lives and have a better quality of life,” he says.

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Education & Training
  • Fellowship - Memorial Sloan Kettering Cancer Institute (2005-2007), Surgical Oncology
  • Residency - University of Wisconsin Hospital and Clinics (1999-2005), Surgery
  • Medical School - Case Western Reserve University School of Medicine (1995-1999)
Professional Associations & Affiliations
  • Society of Surgical Oncology
  • Association for Academic Surgery
  • American Society of Clinical Oncology
  • American College of Surgeons
Honors & Awards
  • Chief Residents Teaching Award 2009
  • Distinguished Surgical Resident Award 2005
  • University of Wisconsin Teacher of the Year 2003
  • Henry M Costello Award- University of Wisconsin 2000
  • Core Clerkship Teaching Award 2008
Books & Publications
Research
  • Expression analysis of gastrointestinal malignancy and treatment selection
  • Multimodality treatment of gastrointestinal, pancreatic, and hepatic malignancy
  • Individualized cancer care

Clinical Focus

  • Liver Cancer
  • Pancreatic Cancer
  • Pancreatic Cancer Prevention
  • Stomach/EG Junction Cancer
  • Surgery for Gastrointestinal Cancer
  • Sarcoma
  • Surgery for Pancreatic Cancer
  • Gallbladder/Bile Duct (Cholangiocarcinoma) Cancer
  • Soft Tissue Sarcoma
  • Pancreatic Disease
  • Gastrointestinal Cancers
  • Gallbladder & Bile Duct Disease
  • Esophageal Cancer
  • Biliary Tract Disorders

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Q&A by Dr. Mansour

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Pancreatic Cancer Prevention Program

at Outpatient Building 1801 Inwood Road, 7th Floor, Suite 100
Dallas, Texas 75390
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Dallas, Texas 75390
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