Jonathan Mosley, M.D., Ph.D.

Internal Medicine - Hypertension

Biography

Jonathan Mosley, M.D., Ph.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center. A clinically trained physician scientist, he specializes in the diagnosis and treatment of resistant hypertension.

Dr. Mosley earned his medical degree and a doctoral degree in clinical pharmacology at Case Western Reserve University. He completed a residency in internal medicine at Vanderbilt University Medical Center, where he also gained advanced training through an internal medicine fellowship. He also holds a master’s degree in epidemiology from Johns Hopkins University.

Certified by the American Board of Internal Medicine, he joined the UT Southwestern faculty in 2025.

Dr. Mosley is a Fellow of the American Heart Association and serves on its Data Science and Precision Medicine Committee. He is also a member of the American Society of Human Genetics. He is an Associate Editor of Circulation and serves on the editorial board of Hypertension.

Dr. Mosley has delivered national and international presentations, contributed to the book Hypertension Secrets, and published more than 115 academic articles related to his areas of expertise.

Personal Note

When he’s not at work, Dr. Mosley enjoys playing jazz guitar and hiking.

Education & Training

Graduate School -

Professional Associations & Affiliations

American Heart Association
American Society of Human Genetics

Honors & Awards

Chancellor’s Award for Research in Diversity, Equity, and Inclusion 2024, Vanderbilt University Medical Center
Clinical Pharmacology Faculty Teaching Award, 2023, 2020, Vanderbilt University Medical Center
Outstanding Reviewer Recognition 2022, Circulation
Manuscript Selected for Top 10 Genomic Medicine Papers 2021, Genomic Medicine Working Group, National Advisory Council of the National Human Genome Research Institute

Books & Publications

Books
- Drug-drug and pharmacogenetic interactions in Hypertension Secrets
  Mosley, JD (2023), Philadelphia, PA, Elsevier
Publications
- A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short stature.
  Shelley JP, Shi M, Peterson JF, Van Driest SL, Simmons JH, Mosley JD, Genome medicine 2025 Mar 17 1 23
- Clinical associations with a polygenic predisposition to benign lower white blood cell counts.
  Mosley JD, Shelley JP, Dickson AL, Zanussi J, Daniel LL, Zheng NS, Bastarache L, Wei WQ, Shi M, Jarvik GP, Rosenthal EA, Khan A, Sherafati A, Kullo IJ, Walunas TL, Glessner J, Hakonarson H, Cox NJ, Roden DM, Frangakis SG, Vanderwerff B, Stein CM, Van Driest SL, Borinstein SC, Shu XO, Zawistowski M, Chung CP, Kawai VK, Nature communications 2024 Apr 15 1 3384
- Branched-chain amino acids and type 2 diabetes: a bidirectional Mendelian randomization analysis.
  Mosley JD, Shi M, Agamasu D, Vaitinadin NS, Murthy VL, Shah RV, Bagheri M, Ferguson JF, Obesity (Silver Spring, Md.) 2024 Feb 32 2 423-435
- Identification of Clinical Drivers of Left Atrial Enlargement Through Genomics of Left Atrial Size.
  Agrawal V, Manouchehri A, Vaitinadin NS, Shi M, Bagheri M, Gupta DK, Kullo IJ, Luo Y, McNally EM, Puckelwartz MJ, Ferguson JF, Wells QS, Mosley JD, Circulation. Heart failure 2024 Jan 17 1 e010557
- Clinical consequences of a genetic predisposition toward higher benign prostate-specific antigen levels.
  Shi M, Shelley JP, Schaffer KR, Tosoian JJ, Bagheri M, Witte JS, Kachuri L, Mosley JD, EBioMedicine 2023 Nov 97 104838
- Coronary Artery Calcium Score and Polygenic Risk Score for the Prediction of Coronary Heart Disease Events.
  Khan SS, Post WS, Guo X, Tan J, Zhu F, Bos D, Sedaghati-Khayat B, van Rooij J, Aday A, Allen NB, Bos MM, Uitterlinden AG, Budoff MJ, Lloyd-Jones DM, Mosley JD, Rotter JI, Greenland P, Kavousi M, JAMA 2023 May 329 20 1768-1777
- A Polygenic Risk Score for Prostate Cancer Risk Prediction.
  Schaffer KR, Shi M, Shelley JP, Tosoian JJ, Kachuri L, Witte JS, Mosley JD, JAMA internal medicine 2023 Apr 183 4 386-388
- White blood cell ranges and frequency of neutropenia by Duffy genotype status.
  Bagheri M, Chung CP, Dickson AL, Van Driest SL, Borinstein SC, Mosley JD, Blood advances 2023 Feb 7 3 406-409
- Race, Genotype, and Azathioprine Discontinuation : A Cohort Study.
  Dickson AL, Daniel LL, Jackson E, Zanussi J, Yang W, Plummer WD, Dupont WD, Wei WQ, Nepal P, Hung AM, Cox NJ, Van Driest SL, Feng Q, Yang JJ, Stein CM, Mosley JD, Chung CP, Annals of internal medicine 2022 Aug 175 8 1092-1099
- Association Between a Common, Benign Genotype and Unnecessary Bone Marrow Biopsies Among African American Patients.
  Van Driest SL, Abul-Husn NS, Glessner JT, Bastarache L, Nirenberg S, Schildcrout JS, Eswarappa MS, Belbin GM, Shaffer CM, Mentch F, Connolly J, Shi M, Stein CM, Roden DM, Hakonarson H, Cox NJ, Borinstein SC, Mosley JD, JAMA internal medicine 2021 Aug 181 8 1100-1105
- Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease.
  Mosley JD, Gupta DK, Tan J, Yao J, Wells QS, Shaffer CM, Kundu S, Robinson-Cohen C, Psaty BM, Rich SS, Post WS, Guo X, Rotter JI, Roden DM, Gerszten RE, Wang TJ, JAMA 2020 Feb 323 7 627-635
- Association of Thyroid Function Genetic Predictors With Atrial Fibrillation: A Phenome-Wide Association Study and Inverse-Variance Weighted Average Meta-analysis.
  Salem JE, Shoemaker MB, Bastarache L, Shaffer CM, Glazer AM, Kroncke B, Wells QS, Shi M, Straub P, Jarvik GP, Larson EB, Velez Edwards DR, Edwards TL, Davis LK, Hakonarson H, Weng C, Fasel D, Knollmann BC, Wang TJ, Denny JC, Ellinor PT, Roden DM, Mosley JD, JAMA cardiology 2019 Feb 4 2 136-143
- Probing the Virtual Proteome to Identify Novel Disease Biomarkers.
  Mosley JD, Benson MD, Smith JG, Melander O, Ngo D, Shaffer CM, Ferguson JF, Herzig MS, McCarty CA, Chute CG, Jarvik GP, Gordon AS, Palmer MR, Crosslin DR, Larson EB, Carrell DS, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Kitchner TE, Linneman JG, Namjou B, Williams MS, Ritchie MD, Borthwick KM, Kiryluk K, Mentch FD, Sleiman PM, Karlson EW, Verma SS, Zhu Y, Vasan RS, Yang Q, Denny JC, Roden DM, Gerszten RE, Wang TJ, Circulation 2018 Nov 138 22 2469-2481
- A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers.
  Mosley JD, Feng Q, Wells QS, Van Driest SL, Shaffer CM, Edwards TL, Bastarache L, Wei WQ, Davis LK, McCarty CA, Thompson W, Chute CG, Jarvik GP, Gordon AS, Palmer MR, Crosslin DR, Larson EB, Carrell DS, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Linneman JG, Namjou B, Williams MS, Ritchie MD, Borthwick KM, Verma SS, Karnes JH, Weiss ST, Wang TJ, Stein CM, Denny JC, Roden DM, Nature communications 2018 Aug 9 1 3522
- Identifying genetically driven clinical phenotypes using linear mixed models.
  Mosley JD, Witte JS, Larkin EK, Bastarache L, Shaffer CM, Karnes JH, Stein CM, Phillips E, Hebbring SJ, Brilliant MH, Mayer J, Ye Z, Roden DM, Denny JC, Nature communications 2016 Apr 7 11433

Research

Complex human genetics
Epidemiology
Health inequities
Risk factors

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