Joshua Gruber, M.D., Ph.D.

Joshua Gruber, M.D., Ph.D.

  • Internal Medicine - Hematology/Oncology
  • Early phase clinical trials
  • Metastatic breast cancer


Joshua Gruber, M.D., Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center. A breast cancer specialist, he has a secondary appointment in UTSW’s Cecil H. and Ida Green Center for Reproductive Biology Sciences.

Dr. Gruber earned his medical degree and doctoral degree in cancer biology and biochemistry at the University of Pennsylvania. He completed a residency in internal medicine at Stanford University, where he also received advanced training through a clinical fellowship in medical oncology and a research fellowship in systems biology of cancer epigenetics.

Certified by the American Board of Internal Medicine in medical oncology, he joined the UT Southwestern faculty in 2021.

Dr. Gruber is the author of numerous scholarly articles in journals such as Cell, Molecular Cell, and Cell Reports, and he serves as a peer reviewer for the Journal of Clinical Oncology Precision Oncology and Clinical Cancer Research.

His clinical focus is on treating patients with metastatic breast cancer and triple-negative breast cancer, as well as conducting early-stage clinical trials on new therapies for these diseases. His laboratory research interests include the molecular biology of breast cancer initiation, the intersection of tumor immunology with cancer growth pathways, and the development of molecular tools to interrogate neoplastic tissues.

He is also focused on gene regulation, specifically the intersection of cancer epigenetics with cellular metabolism. In particular, his work is directed at devising new methods for understanding how metabolic products affect chromatin landscapes as well as developing new chemical probes to interrogate this process.

Dr. Gruber is a member of the American Association for Cancer Research, the American Society of Clinical Oncology, and the Society for Immunotherapy of Cancer.

Education & Training
  • Medical School - University of Pennsylvania Hospital (2007-2011)
  • Residency - Stanford University Medical Center (2011-2013), Internal Medicine
  • Fellowship - Stanford University Hospital (2013-2016), Medical Oncology
  • Other Post Graduate Training - University of Pennsylvania (2004-2008)
  • Internship - Stanford University (2011-2012)
Professional Associations & Affiliations
  • American Association for Cancer Research
  • American Society of Clinical Oncology
  • Society for Immunotherapy of Cancer
Honors & Awards
  • Recruitment of First-time, Tenure-Track Faculty Member Award 2020, Cancer Prevention and Research Institute of Texas (CPRIT)
  • Mentored Clinical Scientist Research Development Award (K08) 2020, National Institutes of Health/National Cancer Institute (NIH/NCI)
  • Women’s Cancer Innovation Award 2020, Stanford Cancer Institute
  • SPARK Translational Research Award 2020, Stanford University
  • Cancer Institute Innovation Award 2017, Stanford University
  • Young Investigator Award 2017, American Society of Clinical Oncology & Conquer Cancer Foundation
  • Postdoctoral Fellowship 2017, Susan G. Komen Foundation
  • Scholar-in-Training Award 2016, San Antonio Breast Cancer Symposium
  • Research Fellowship 2016, Stanford Cancer Institute
  • Jane Coffin Childs Postdoctoral Fellowship 2015
Books & Publications
  • Development of molecular tools to interrogate neoplastic tissues
  • Intersection of tumor immunology with cancer growth pathways
  • Molecular biology of breast cancer

Clinical Focus

  • Early phase clinical trials
  • Metastatic breast cancer
  • Triple-negative breast cancer

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