Markey McNutt II, M.D., Ph.D.

Internal Medicine - Clinical Genetics

Biography

Markey Carden McNutt II, M.D., Ph.D., is an Associate Professor in the Departments of Internal Medicine and Pediatrics and the Eugene McDermott Center for Human Growth and Development at UT Southwestern Medical Center. He specializes in genetics and inherited metabolic disorders.

Dr. McNutt earned his medical degree at UT Southwestern, where he also completed residencies in internal medicine and clinical genetics and a fellowship in endocrinology.

Certified by American Board of Internal Medicine and the American Board of Medical Genetics and Genomics, Dr. McNutt joined the UT Southwestern faculty in 2017.

He is a member of the Alpha Omega Alpha Honor Medical Society, the American Association of Clinical Endocrinologists, the American College of Medical Genetics and Genomics, the American Heart Association, the American Medical Association, the Dallas County Medical Society, the Endocrine Society, the Society for Inherited Metabolic Disorders, and the Texas Medical Association.

Dr. McNutt is a Texas Monthly Super Doctor Rising Star.

Education & Training

Residency - UT Southwestern Medical Center (2010-2012), Internal Medicine
Medical School - UT Southwestern Medical School (2003-2010)
Residency - UT Southwestern/Children's Medical Center (2015-2017), Medical Genetics
Fellowship - UT Southwestern Medical Center (2012-2015), Endocrinology & Metabolism

Honors & Awards

D Magazine Best Pediatric Specialist 2020
Texas Monthly Super Doctors, Rising Star 2020
Texas Monthly Super Doctors, Rising Star 2019

Books & Publications

Publications
- Identifying Subclinical Transthyretin Cardiac Amyloidosis in V142I TTR Carriers: Design, Rationale, and Methods of the VISTA (Variant Imaging of Subclinical Transthyretin Amyloidosis) Study
  Jefferson A, Kozlitina J, Zaha VG, Hanna M, Kwon D, Einstein AJ, Roth LR, McNutt M, Hathorn B, Saelices L, Phillips L, Maurer MS, Tang WH, Nelson M, Grodin JL American Journal of Cardiology 2026 Apr 264 56-63
- Clinical Characteristics of Arginase 1 Deficiency: Natural History Insights From International Clinical Trials
  Rudebeck M, Braverman N, Chang R, Enns GM, Ghosh A, Gorce M, Karall D, Sharma R, Shelkowitz E, Zori R, McNutt M Journal of Inherited Metabolic Disease 2026 Mar 49
- Long-Term Efficacy and Tolerability of Pegzilarginase in Arginase 1 Deficiency: Results of Two International Multicentre Open-Label Extension Studies
  McNutt M, Rutsch F, Russo RS, Gasperini S, Batzios S, Teles EL, Brassier A, Ganesh J, Schulze A, Enns GM, Rudebeck M Journal of Inherited Metabolic Disease 2025 Jul 48
- Phenylketonuria in adults: we know plenty, but there is much more to learn
  Author Collaboration Mo, Harding CO, Arnold G, Berry GT, Christ SE, Grange DK, Jurecki E, Levy H, Lichter-Konecki U, Longo N, McNutt M, Meachum P, Sacharow S, Shayota B, Thomas J, Vucko E American Journal of Clinical Nutrition 2025 Mar 121 741-743
- Monitoring and integrated care coordination of patients with alpha-mannosidosis: A global Delphi consensus study
  Guffon N, Burton BK, Ficicioglu C, Magner M, Gil-Campos M, Lopez-Rodriguez MA, Jayakar P, Lund AM, Tal G, Garcia-Ortiz JE, Stepien KM, Ellaway C, Al-Hertani W, Giugliani R, Cathey SS, Hennermann JB, Lampe C, McNutt M, Lagler FB, Scarpa M, Sutton VR, Muschol N Molecular Genetics and Metabolism 2024 Aug 142
- Fatal consequences of limited health literacy in a patient with a rare metabolic disease
  McNutt MC Molecular Genetics and Metabolism Reports 2024 Aug 39
- Outcomes in 14 live births resulting from Pegvaliase-treated pregnancies in PKU-affected females
  Bier C, Dickey K, Bibb B, Crutcher A, Sponberg R, Chang R, Boyer M, Davis-Keppen L, Matthes C, Tharp M, Vice D, Cooney E, Morand M, Ray J, Lah M, McNutt M, Andersson HC Molecular Genetics and Metabolism 2024 Mar 141
- A 20-year-old woman with chronic cough and dyspnea
  Sun JL, Chen L, Ghazi A, McNutt MC, Mathai SK, Millard M Baylor University Medical Center Proceedings 2024
- Best practice recommendations for the management of anxiety during the pegvaliase journey
  Bjoraker KJ, Eggerding C, Ellenberg E, Hollander S, Holmes BM, Lindstrom K, McNutt M, Miller S, Northrup H, Rogers M, Rose S, Scott M, Shim S, Wardley B, Wessenberg L, Bilder DA Molecular Genetics and Metabolism 2024 Jan 141
- Partial N-acetyl glutamate synthase deficiency presenting as postpartum hyperammonemia: Diagnosis and subsequent pregnancy management
  Abou Haidar L, Pachnis P, Gotway GK, Ni M, DeBerardinis RJ, McNutt MC JIMD Reports 2023 Nov 64 403-409
- Arginase 1 Deficiency in Patients Initially Diagnosed with Hereditary Spastic Paraplegia
  McNutt MC, Foreman N, Gotway G Movement Disorders Clinical Practice 2023 Jan 10 109-114
- Management of early treated adolescents and young adults with phenylketonuria: Development of international consensus recommendations using a modified Delphi approach
  Burton BK, Hermida Á, Bélanger-Quintana A, Bell H, Bjoraker KJ, Christ SE, Grant ML, Harding CO, Huijbregts SC, Longo N, McNutt MC, Nguyen-Driver MD, Santos Pessoa AL, Rocha JC, Sacharow S, Sanchez-Valle A, Sivri HS, Vockley J, Walterfang M, Whittle S, Muntau AC Molecular Genetics and Metabolism 2022 Sep 137 114-126
- Gene delivery corrects N-acetylglutamate synthase deficiency and enables insights in the physiological impact of L-arginine activation of N-acetylglutamate synthase
  Sonaimuthu P, Senkevitch E, Haskins N, Uapinyoying P, McNutt M, Morizono H, Tuchman M, Caldovic L Scientific reports 2021 Dec 11
- Use of pegvaliase in the management of phenylketonuria: Case series of early experience in US clinics
  Adams D, Andersson HC, Bausell H, Crivelly K, Eggerding C, Lah M, Lilienstein J, Lindstrom K, McNutt M, Ray JW, Saavedra H, Sacharow S, Starin D, Tiffany-Amaro J, Thomas J, Vucko E, Wessenberg LB, Whitehall K Molecular Genetics and Metabolism Reports 2021 Sep 28
- Clinical effect and safety profile of pegzilarginase in patients with arginase 1 deficiency
  Diaz GA, Schulze A, McNutt MC, Leão-Teles E, Merritt JL, Enns GM, Batzios S, Bannick A, Zori RT, Sloan LS, Potts SL, Bubb G, Quinn AG Journal of Inherited Metabolic Disease 2021 Jul 44 847-856
- Brody Myopathy Presenting as Recurrent Rhabdomyolysis
  Bergstrom C, Remz M, Khan S, McNutt M American Journal of Medicine 2021 Jul 134 e429-e430
- A randomized, double-blind, placebo-controlled proof-of-concept study of ondansetron for bipolar and related disorders and alcohol use disorder
  Sherwood Brown E, McArdle M, Palka J, Bice C, Ivleva E, Nakamura A, McNutt M, Patel Z, Holmes T, Tipton S European Neuropsychopharmacology 2021 Feb 43 92-101
- Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans
  Ni M, Solmonson A, Pan C, Yang C, Li D, Notzon A, Cai L, Guevara G, Zacharias LG, Faubert B, Vu HS, Jiang L, Ko B, Morales NM, Pei J, Vale G, Rakheja D, Grishin NV, McDonald JG, Gotway GK, McNutt MC, Pascual JM, DeBerardinis RJ Cell Reports 2019 Apr 27 1376-1386.e6
- So Far, PCSK9 Inhibitors Work for All Heterozygous FH Patients
  McNutt MC, Ahmad Z Circulation: Cardiovascular Genetics 2015 Dec 8 749-751
- Hepatic ANGPTL3 regulates adipose tissue energy homeostasis
  Wang Y, McNutt MC, Banfi S, Levin MG, Holland WL, Gusarova V, Gromada J, Cohen JC, Hobbs HH Proceedings of the National Academy of Sciences of the United States of America 2015 Sep 112 11630-11635
- Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells
  McNutt MC, Kwon HJ, Chen C, Chen JR, Horton JD, Lagace TA Journal of Biological Chemistry 2009 Apr 284 10561-10570
- Plasma PCSK9 preferentially reduces liver LDL receptors in mice
  Grefhorst A, McNutt MC, Lagace TA, Horton JD Journal of lipid research 2008 Jun 49 1303-1311
- Molecular basis for LDL receptor recognition by PCSK9
  Hyock JK, Lagace TA, McNutt MC, Horton JD, Deisenhofer J Proceedings of the National Academy of Sciences of the United States of America 2008 Feb 105 1820-1825
- Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells
  McNutt MC, Lagace TA, Horton JD Journal of Biological Chemistry 2007 Jul 282 20799-20803
- Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice
  Lagace TA, Curtis DE, Garuti R, McNutt MC, Sahng WP, Prather HB, Anderson NN, Ho YK, Hammer RE, Horton JD Journal of Clinical Investigation 2006 Nov 116 2995-3005
- Human promoter genomic composition demonstrates non-random groupings that reflect general cellular function
  McNutt MC, Tongbai R, Cui W, Collins I, Freebern WJ, Montano I, Haggerty CM, Chandramouli GV, Gardner K BMC Bioinformatics 2005 Oct 6
- Pharmacologic profiling of transcriptional targets deciphers promoter logic
  Freebern WJ, Haggerty CM, Montano I, McNutt MC, Collins I, Graham A, Chandramouli GV, Stewart DH, Biebuyck HA, Taub DD, Gardner K Pharmacogenomics Journal 2005 5 305-323
- Kinetic profiles of p300 occupancy in vivo predict common of promoter structure and coactivator recruitment
  Smith JL, Freebern WJ, Collins I, De Siervi A, Montano I, Haggerty CM, McNutt MC, Butscher WG, Dzekunovat I, Petersen DW, Kawasaki E, Merchant JL, Gardner K Proceedings of the National Academy of Sciences of the United States of America 2004 Aug 101 11554-11559

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Markey McNutt II, M.D., Ph.D.

Biography

Education & Training

Honors & Awards

Books & Publications

Clinical Genetics - Internal Medicine Subspecialties Clinic

Markey McNutt II, M.D., Ph.D.

Biography

Education & Training

Honors & Awards

Books & Publications

Clinical Genetics - Internal Medicine Subspecialties Clinic

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