Samuel John, M.D.

Samuel John, M.D.

  • Pediatrics - Hematology-Oncology
  • Acute lymphoblastic leukemia (ALL)
  • Acute Myeloid Leukemia (AML)


Samuel John, M.D., is an Assistant Professor in the Department of Pediatrics at UT Southwestern Medical Center. He specializes in pediatric blood cancers, cellular therapy, and cancer immunotherapy.

Dr. John earned his medical degree at Albany Medical College. He performed his residency in pediatrics at UT Southwestern and Children’s Medical Center, where he also completed a fellowship in pediatric hematology and oncology.

Certified by the American Board of Pediatrics in pediatric hematology and oncology, he joined the UT Southwestern faculty in 2017.

Dr. John serves as the CAR T-Cell Therapy Program leader for UT Southwestern and Children’s Medical Center. He is a member of several professional organizations, including the Children’s Oncology Group, the American Society of Hematology, and the American Society of Pediatric Hematology/Oncology.

His clinical and research interests include cancer immunotherapies and cellular therapies, acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML). He is the Principal Investigator at UT Southwestern for pediatric cell therapy clinical trials for leukemia and certain solid tumors.

Dr. John’s joint research with Alec Zhang, Ph.D., has developed a novel CAR T-cell therapy for AML, which they are working to move into clinical trials. They are also developing CAR T-cells for other cancers, including both adult and pediatric solid tumors.

Additionally, he studies infant leukemia biology in order to develop novel ways to target and treat this disease.

Dr. John was one of Texas Monthly’s Super Doctors Rising Stars in 2020.

Education & Training
  • Fellowship - UT Southwestern/Children's Medical Center (2014-2017), Pediatric Hematology/oncology
  • Medical School - Albany Medical College (2007-2011)
  • Residency - UT Southwestern/Children's Medical Center (2011-2014), Pediatrics
Professional Associations & Affiliations
  • American Society of Clinical Oncology
  • American Society of Hematology
  • American Society of Pediatric Hematology- Oncology
  • Children’s Oncology Group
  • Society for Immunotherapy of Cancer
Honors & Awards
  • Super Doctors Rising Star 2020, Texas Monthly
  • Award for Clinical Excellence - Pediatric Residency 2013-2014, UT Southwestern/Children’s Medical Center
  • Gold Humanism Honor Society Inductee 2011, Albany Medical College
Books & Publications
  • Acute lymphoblastic leukemia (ALL)
  • Acute myeloid leukemia (AML)
  • Cellular therapy (CAR T-cell)
  • Cancer immunotherapy

Clinical Focus

  • Acute lymphoblastic leukemia (ALL)
  • Acute Myeloid Leukemia (AML)
  • Cellular therapy (CAR T-cell)
  • Cancer Immunotherapy

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