- Residency - Boston University Medical Center (2003-2006), Internal Medicine
- Medical School - Jefferson Medical College of Thomas (1999-2003)
- Fellowship - Northwestern University (2009-2012), Cardiology
- Research Fellowship - Baylor College of Medicine (2007-2009), Cardiology
Satyam (Tom) Sarma, M.D.
- Internal Medicine - Cardiology
- General Cardiology
- Cancer & Heart Disease
Satyam Sarma, M.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of its Cardiology Division.
Dr. Sarma became interested in cardiovascular diseases during his undergraduate studies in engineering. He pursued medical training at Boston University, where he also served as Chief Medical Resident.
Interested in molecular biology research, he worked at Baylor Medical College as a postdoctoral fellow in the Department of Biophysics and Molecular Physiology, focusing on abnormalities in cardiac ryanodine receptor function. After two years of research fellowship, he went on to complete a clinical cardiology fellowship at Northwestern University, where he was selected as Chief Cardiology Fellow during his second year.
Dr. Sarma is interested in heart failure with preserved ejection fraction (HFpEF), a type of heart failure common in seniors, and came to UT Southwestern in 2012 to study new treatment options for patients with this common but difficult-to-treat condition.
He also specializes in metabolic disorders, specifically diabetes and insulin resistance, and his clinical practice focuses on exercise training programs to improve patient symptoms and quality of life.
Dr. Sarma is an avid runner and enjoys working with his hands. A violinist since childhood, he also enjoys origami – which, like playing the violin, is all about combining artistic inspiration with precision. “The fold that you make at the first or second step, if you don't do it right it's going to come back to haunt you 15 steps down the line. Those little imperfections add up.”
Meet Dr. Sarma
Diastolic Heart Failure Specialist in Dallas
Satyam (Tom) Sarma, M.D., is a cardiologist by title, but he describes his work as integrated physiology – studying and treating the human body as a unified system.
Dr. Sarma draws on his experience in a variety of fields, including biomedical engineering, cardiology, and exercise physiology, to understand how the heart, lungs, muscles, and blood vessels work together.
A clinical scholar at UT Southwestern Medical Center, Dr. Sarma splits his time between patient care and research. Much of his work centers on understanding, diagnosing, and treating unexplained shortness of breath. In addition to caring for patients with heart failure and other serious illnesses, Dr. Sarma often works with athletes to examine and improve their performance.
“From the framework of integrated physiology, you can really address a variety of different patients, from the elite athlete to the person with heart failure who can't even walk across the room.”
Research Aligned with Patient Care
With his holistic focus on the human body, Dr. Sarma is often able to see things in a unique way.
“Many patients who come to see me have been told they have pulmonary hypertension, a disorder in which lung pressure is elevated,” Dr. Sarma says. “But often it turns out they actually have a particular type of heart failure.”
This type of heart failure, called HFpEF, or heart failure with preserved ejection fraction, creates an elevated pressure in the heart and lungs and can cause significant shortness of breath.
“There's no gold standard of diagnosis for HFpEF, so it can be very challenging for a lot of patients, who often have already seen other physicians but have been unable to get a conclusive diagnosis.”
The exact mechanisms that underlie both HFpEF and shortness of breath aren’t well understood, so Dr. Sarma’s research focuses on unpacking the enigmas of these disorders. One of his great satisfactions is how closely his clinical research aligns with his clinical practice.
“We see our research as a partnership with patients,” he says. “Ultimately we're here to help people, but at the same time, patients can help us. We've learned so much from our patients, and our patients enjoy participating in research because it helps them understand their body and their disease better. It’s mutually beneficial.”
- American Heart Association (2008), Member
- American College of Cardiology (2008), Member
- Alpha Omega Alpha 2007, Medical Honor Society
- 2nd Place 2008, Northwestern University Young Investigators Forum
- Robert O. Bonow, M.D. Award for Excellence in Research 2010, Northwestern University
- Medical Student Clinical Teaching Award 2012, Northwestern University
Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.
Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH The Journal of clinical investigation 2009 Jul 119 7 1940-51
Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.
Sarma S, Li N, van Oort RJ, Reynolds C, Skapura DG, Wehrens XH Proceedings of the National Academy of Sciences of the United States of America 2010 Jul 107 29 13165-70
Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1.
Koshelev M, Sarma S, Price RE, Wehrens XH, Cooper TA Human molecular genetics 2010 Mar 19 6 1066-75
Nutritional assessment and support of the patient with acute heart failure.
Sarma S, Gheorghiade M Current opinion in critical care 2010 Oct 16 5 413-8
Use of clinically available PPAR agonists for heart failure; do the risks outweigh the potential benefits?
Sarma S Current molecular pharmacology 2012 Jun 5 2 255-63
Exercise as a physiologic intervention to counteract hypertension: can a good idea go bad?
Sarma S, Schulze PC Hypertension 2007 Aug 50 2 294-6
Association between diabetes mellitus and post-discharge outcomes in patients hospitalized with heart failure: findings from the EVEREST trial.
Sarma S, Mentz RJ, Kwasny MJ, Fought AJ, Huffman M, Subacius H, Nodari S, Konstam M, Swedberg K, Maggioni AP, Zannad F, Bonow RO, Gheorghiade M European journal of heart failure 2013 Feb 15 2 194-202
The Effects of Age and Aerobic Fitness on Myocardial Lipid Content.
Sarma S, Carrick-Ranson G, Fujimoto N, Adams-Huet B, Bhella PS, Hastings JL, Shafer KM, Shibata S, Boyd K, Palmer D, Szczepaniak EW, Szczepaniak LS, Levine BD Circulation. Cardiovascular imaging 2013 Sep
- Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.
- Heart Failure
- Exercise Training
- Cardiopulmonary Exercise Testing
- Cardiac Steatosis
- General Cardiology
- Cancer & Heart Disease
- Sports Cardiology
- Diabetes & Heart Disease