Ty Shang, M.D., Ph.D.

Peter O'Donnell Jr. Brain Institute

Neurology
Cerebrovascular Disease
Stroke

Biography

Dr. Ty Shang, M.D., Ph.D., is an Associate Professor in UT Southwestern Medical Center’s Department of Neurology.

An expert in cerebrovascular disease and stroke, Dr. Shang is a member of UT Southwestern’s world-class stroke team. He also serves as assistant director of the Vascular Neurology/Stroke Fellowship Program.

He joined the UT Southwestern faculty in 2012.

Active in research Dr. Shang has published approximately 30 journal articles and abstracts, as well as four book chapters.

He currently serves as site principal investigator (PI) for an NIH-funded study of intravenous thrombolysis plus hypothermia for acute treatment of ischemic stroke.

He also is the PI for three departmental studies: one aimed at creating a Moyamoya disease/syndrome registry, one examining cerebral cavernous angioma and statin use, and one looking at a biomarker in acute ischemic stroke.

Dr. Shang earned his medical degree at China’s Shandong University School of Medicine and his Ph.D. in neuroscience at the Medical College of Wisconsin. He also holds a master’s degree in radiology from the Beijing Institute of Traumatology and Orthopaedics.

He completed postdoctoral training in neuroscience at the National Institutes of Health, as well as in internal medicine, neurology, and vascular neurology at the University of Miami.

In the 1990s, Dr. Shang served as a staff physician at Qingzhou People’s Hospital (medicine) and Beijing Jishuitan Hospital – an affiliated hospital of Beijing Medical University (radiology), both in China.

He is a member of professional organizations that include the American Academy of Neurology (AAN), American Stroke Association, American Heart Association, Society for Neuroscience, and the Society of Vascular and Interventional Neurology (SVIN).

Dr. Shang’s honors include being awarded the AAN’s 2012 Annual Meeting Fellow Scholarship and two 2010 SVIN Resident Travel Grants.

Meet Dr. Shang

Stroke and Cerebrovascular Disease Specialist in Dallas

Undiagnosed, misdiagnosed, or untreated cerebrovascular conditions (conditions that affect blood vessels in the brain), along with other risk factors, can lead to a stroke.

As a vascular neurologist at UT Southwestern Medical Center, Ty Shang, M.D., Ph.D., has the expertise to diagnose cerebrovascular diseases and stroke, and to make sure patients receive evidence-based care to improve treatments and prevent strokes from occurring.

Identifying the causes of a stroke can be like detective work, Shang says, and “solving” the case is very rewarding.

“We put together all the clues and find out what happened in the past – the factors that caused someone to develop cerebrovascular disease or have a stroke,” he says.

“We’re able to use sophisticated imaging to precisely pinpoint the lesion in the brain, treat the underlying mechanisms, and avert future problems, which I think is the best part of being a vascular neurologist.”

Dr. Shang also sees referred patients for whom neuroimages (such as MRI, CT angiogram, or carotid duplex) have indicated cerebrovascular disease, as well as patients seeking an expert second opinion. He is certified to read neurosonology studies, such as carotid duplex and transcranial Doppler, which gives him a particularly thorough understanding of patient issues.

“Every patient, every case of cerebrovascular disease, and every stroke is different,” Dr. Shang says. “By treating patients based on what has caused the problem, I provide very individualized care.”

Dr. Shang is a leader in UT Southwestern’s Comprehensive Stroke Center, which is nationally recognized for the quality of care delivered and patient outcomes. In addition to his clinical responsibilities, he helps to train future vascular neurologists in his role as Assistant Director of UT Southwestern’s Stroke Fellowship Program. He also conducts research, with the goal of translating it to continually improving clinical care.

“I’m very proud of the comprehensive care we provide – from acute care to stroke prevention – and the high level of successful outcomes we’re able to achieve for our patients,” he says. “These things make UT Southwestern one of the best centers for the treatment of cerebrovascular disease and stroke.”

Education & Training

Other Post Graduate Training - Medical College of Wisconsin (1999-2005)
Medical School - Shandong Medical University, China (1988-1993)
Internship - Qingdao University/ Affiliated Hospital, China (1993-1994), Medicine
Fellowship - University of Miami (2011-2012), Vascular Neurology
Residency - University of Miami (2008-2011), Neurology
Internship - University of Miami (2007-2008), Internal Medicine
Fellowship - NIH National Cancer Institute - Office of Education (2005-2007), Neuroscience
Graduate School - Medical College of Wisconsin (1999-2005), Neuroscience

Honors & Awards

Resident Travel Grant Award 2010, Society of Vascular and Interventional Neurology (SVIN) 3rd Annual Meeting
American Academy of Neurology Institutes (AANI) Annual Meeting Fellow Scholarship 2012, The 64th Annual meeting of AAN

Books & Publications

Books
- Chapter 8 Acute Stroke Evaluation and Management. in Emergency Neurology.
  Ty Shang, Dileep Yavagal, Jose Romano, Ralph Sacco (2012), New York, Springer
Publications
- Association of distal hyperintense vessel sign and recurrent stroke in patients with symptomatic intracranial stenosis
  Salahuddin H, Saherwala A, Pinho MC, Moore W, Castonguay A, Khan NI, Jeelani F, Uppal H, He H, Campbell J, Shang T Journal of Stroke and Cerebrovascular Diseases 2022 Sep 31
- Q-15 Minutes Vital Sign Documentation Is a Poor Surrogate for Assessing Quality of Care after Acute Ischemic Stroke
  Stone S, Zhao H, Nyancho D, Schneider NJ, Shang T, Olson DM Dimensions of Critical Care Nursing 2021 Nov 40 328-332
- Two Unique Mutations in HTRA1-Related Cerebral Small Vessel Disease in North America and Africa and Literature Review
  Shang T, Pinho M, Ray D, Khera A Journal of Stroke and Cerebrovascular Diseases 2021 Nov 30
- Impact of MRI Selection on Triage of Endovascular Therapy in Acute Ischemic Stroke: The MRI in Acute Management of Ischemic Stroke (MIAMIS) Registry
  Atchaneeyasakul K, Shang T, Haussen D, Ortiz G, Yavagal D Interventional Neurology 2020 Jan 8 135-143
- Prevalence of and Risk Factors for Cerebral Microbleeds in Moyamoya Disease and Syndrome in the American Population
  Khan NI, Saherwala AA, Chen M, Salehian S, Salahuddin H, Welch BG, Pinho MC, Shang T Cerebrovascular Diseases Extra 2019 9 139-147
- Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial
  Author Collaboration NE, Kasner SE, Swaminathan B, Lavados P, Sharma M, Muir K, Veltkamp R, Ameriso SF, Endres M, Lutsep H, Messé SR, Spence JD, Nedeltechev K, Perera K, Santo G, Olavarria V, Lindgren A, Bangdiwala S, Shoamanesh A, Berkowitz SD, Mundl H, Connolly SJ, Hart RG, Abdelhamid N, Abdul Rahman D, Abdul-Saheb M, Abreu P, Abroskina M, Abu Ahmad F, Accassat S, Acciaresi M, Adami A, Ahmad N, Ahmed F, Alberto Hawkes M, Alemseged F, Ali A, Altavilla R, Alwis L, Amarenco P, Amaro S, Amaya Sanchez LE, Amelia Pinto A, Ameriso SF, Amin H, Amino T, Amjad AK, Gebreyohanns M, Johnson M, Magadan A, Shang T The Lancet Neurology 2018 Dec 17 1053-1060
- Unveiling a hidden ³¹P signal coresonating with extracellular inorganic phosphate by outer-volume-suppression and localized ³¹P MRS in the human brain at 7T
  Ren J, Shang T, Sherry AD, Malloy CR Magnetic resonance in medicine 2018 Oct 80 1289-1297
- Impaired cerebral autoregulation: Measurement and application to stroke
  Xiong L, Liu X, Shang T, Smielewski P, Donnelly J, Guo ZN, Yang Y, Leung T, Czosnyka M, Zhang R, Liu J, Wong KS Journal of Neurology, Neurosurgery and psychiatry 2017 Jun 88 520-531
- Clinical Reasoning: A 76-year-old man with acute-onset left-sided weakness and numbness
  Renthal W, Alberts M, Shang T Neurology 2016 Apr 86 e156-e160
- Endovascular therapy for acute ischemic stroke: Dawn of anew era
  Alberts MJ, Shang T, Magadan A JAMA neurology 2015 Oct 72 1101-1103
- Bilateral asymmetrical asterixis as limb-shaking transient ischemic attack in bilateral carotid stenosis
  Khan S, Chang E, Saniuk G, Shang T Journal of Stroke and Cerebrovascular Diseases 2015 Jan 24 e29-e30
- Letter by Shang et al regarding article, "high-resolution magnetic resonance wall imaging findings of moyamoya disease"
  Shang T, Welch B, Pinho M Stroke 2014 Dec 45
- Letter by shang regarding article, " relative contributions of sympathetic, cholinergic, and myogenic mechanisms to cerebral autoregulation"
  Shang T Stroke 2014 Oct 45 e208
- Differences in lipid profiles in two Hispanic ischemic stroke populations
  Arauz A, Romano JG, Ruiz-Franco A, Shang T, Dong C, Rundek T, Koch S, Hernández-Curiel B, Pacheco J, Rojas P, Ruiz-Navarro F, Katsnelson M, Sacco RL International Journal of Stroke 2014 Jun 9 394-399
- FLAIR Distal hyperintense vessels as a marker of perfusion-diffusion mismatch in acute stroke
  Haussen DC, Koch S, Saraf-Lavi E, Shang T, Dharmadhikari S, Yavagal DR Journal of Neuroimaging 2013 Jul 23 397-400
- Cerebral hemodynamics and cognitive performance in bilateral asymptomatic carotid stenosis
  Shang T Neurology 2013 May 80 2080
- Application of acute stroke imaging: Selecting patients for revascularization therapy
  Shang T, Yavagal DR Neurology 2012 Sep 79 S86-S94
- Acute stroke evaluation and management
  Shang TT, Yavagal DR, Romano JG, Sacco RL 2012 Jan 143-160
- JC virus granule cell neuronopathy and hyper-IgE in HIV disease
  Shang T, Delgado A, Adams D Neurology 2011 May 76 1941-1942
- Upregulation of immunoproteasomes by nitric oxide: Potential antioxidative mechanism in endothelial cells
  Kotamraju S, Matalon S, Matsunaga T, Shang T, Hickman-Davis JM, Kalyanaraman B Free Radical Biology and Medicine 2006 Mar 40 1034-1044
- Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: Role of tetrahydrobiopterin, nitric oxide, and proteasome activation
  Shang T, Kotamraju S, Zhao H, Kalivendi SV, Hillard CJ, Kalyanaraman B Free Radical Biology and Medicine 2005 Oct 39 1059-1074
- Death-associated protein kinase as a sensor of mitochondrial membrane potential: Role of lysosome in mitochondrial toxin-induced cell death
  Shang T, Joseph J, Hillard CJ, Kalyanaraman B Journal of Biological Chemistry 2005 Oct 280 34644-34653
- Nitric oxide, proteasomal function, and iron homeostasis - Implications in aging and neurodegenerative diseases
  Kotamraju S, Kalivendi S, Shang T, Kalyanaraman B Methods in Enzymology 2005 396 526-534
- Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis
  Dhanasekaran A, Kotamraju S, Kalivendi SV, Matsunaga T, Shang T, Keszler A, Joseph J, Kalyanaraman B Journal of Biological Chemistry 2004 Sep 279 37575-37587
- 1-Methyl-4-phenylpyridinium-induced Apoptosis in Cerebellar Granule Neurons Is Mediated by Transferrin Receptor Iron-dependent Depletion of Tetrahydrobiopterin and Neuronal Nitric-oxide Synthase-derived Superoxide
  Shang T, Kotamraju S, Kalivendi SV, Hillard CJ, Kalyanaraman B Journal of Biological Chemistry 2004 Apr 279 19099-19112
- 1-Methyl-4-phenylpyridinium (MPP⁺)-induced apoptosis and mitochondrial oxidant generation: Role of transferrin-receptor-dependent iron and hydrogen peroxide
  Kalivendi SV, Kotamraju S, Cunningham S, Shang T, Hillard CJ, Kalyanaraman B Biochemical Journal 2003 Apr 371 151-164
- 1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3
  Shang T, Uihlein AV, Van Asten J, Kalyanaraman B, Hillard CJ Journal of Neurochemistry 2003 Apr 85 358-367

Research

Small vessel disease and neurovascular unit
Progressive multifocal leukoencephalopathy in HIV disease
Posterior Reversible Encephalopathy Syndrome & Reversible Cerebral Vasoconstriction Syndrome
Penumbra evolution in ischemic stroke
Moyamoya disease and Moyamoya syndrome
Hemorrhagic transformation in ischemic stroke
Delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage
Cerebral edema in malignant infarct

Clinical Focus

Cerebrovascular Disease
Stroke
Neurorehabilitation