- Fellowship - University of Miami (2011-2012), Vascular Neurology
- Residency - University of Miami (2008-2011), Neurology
- Internship - University of Miami (2007-2008), Internal Medicine
- Fellowship - NIH National Cancer Institute - Office of Education (2005-2007), Neuroscience
- Graduate School - Medical College of Wisconsin (1999-2005), Neuroscience
- Internship - Qingdao University/ Affiliated Hospital, China (1993-1994), Medicine
- Medical School - Shandong Medical University, China (1988-1993)
Ty Shang, M.D., Ph.D.
- Cerebrovascular Disease
Dr. Ty Shang, M.D., Ph.D., is an Assistant Professor in UT Southwestern Medical Center’s Department of Neurology and Neurotherapeutics.
An expert in cerebrovascular disease and stroke, Dr. Shang is a member of UT Southwestern’s world-class stroke team. He also serves as assistant director of the Vascular Neurology/Stroke Fellowship Program.
He joined the UT Southwestern faculty in 2012.
Active in research Dr. Shang has published approximately 30 journal articles and abstracts, as well as four book chapters.
He currently serves as site principal investigator (PI) for an NIH-funded study of intravenous thrombolysis plus hypothermia for acute treatment of ischemic stroke.
He also is the PI for three departmental studies: one aimed at creating a Moyamoya disease/syndrome registry, one examining cerebral cavernous angioma and statin use, and one looking at a biomarker in acute ischemic stroke.
Dr. Shang earned his medical degree at China’s Shandong University School of Medicine and his Ph.D. in neuroscience at the Medical College of Wisconsin. He also holds a master’s degree in radiology from the Beijing Institute of Traumatology and Orthopaedics.
He completed postdoctoral training in neuroscience at the National Institutes of Health, as well as in internal medicine, neurology, and vascular neurology at the University of Miami.
In the 1990s, Dr. Shang served as a staff physician at Qingzhou People’s Hospital (medicine) and Beijing Jishuitan Hospital – an affiliated hospital of Beijing Medical University (radiology), both in China.
He is a member of professional organizations that include the American Academy of Neurology (AAN), American Stroke Association, American Heart Association, Society for Neuroscience, and the Society of Vascular and Interventional Neurology (SVIN).
Dr. Shang’s honors include being awarded the AAN’s 2012 Annual Meeting Fellow Scholarship and two 2010 SVIN Resident Travel Grants.
Meet Dr. Shang
Stroke and Cerebrovascular Disease Specialist in Dallas
Undiagnosed, misdiagnosed, or untreated cerebrovascular conditions (conditions that affect blood vessels in the brain), along with other risk factors, can lead to a stroke.
As a vascular neurologist at UT Southwestern Medical Center, Ty Shang, M.D., Ph.D., has the expertise to diagnose cerebrovascular diseases and stroke, and to make sure patients receive evidence-based care to improve treatments and prevent strokes from occurring.
Identifying the causes of a stroke can be like detective work, Shang says, and “solving” the case is very rewarding.
“We put together all the clues and find out what happened in the past – the factors that caused someone to develop cerebrovascular disease or have a stroke,” he says.
“We’re able to use sophisticated imaging to precisely pinpoint the lesion in the brain, treat the underlying mechanisms, and avert future problems, which I think is the best part of being a vascular neurologist.”
Dr. Shang also sees referred patients for whom neuroimages (such as MRI, CT angiogram, or carotid duplex) have indicated cerebrovascular disease, as well as patients seeking an expert second opinion. He is certified to read neurosonology studies, such as carotid duplex and transcranial Doppler, which gives him a particularly thorough understanding of patient issues.
“Every patient, every case of cerebrovascular disease, and every stroke is different,” Dr. Shang says. “By treating patients based on what has caused the problem, I provide very individualized care.”
Dr. Shang is a leader in UT Southwestern’s Comprehensive Stroke Center, which is nationally recognized for the quality of care delivered and patient outcomes. In addition to his clinical responsibilities, he helps to train future vascular neurologists in his role as Assistant Director of UT Southwestern’s Stroke Fellowship Program. He also conducts research, with the goal of translating it to continually improving clinical care.
“I’m very proud of the comprehensive care we provide – from acute care to stroke prevention – and the high level of successful outcomes we’re able to achieve for our patients,” he says. “These things make UT Southwestern one of the best centers for the treatment of cerebrovascular disease and stroke.”
- Resident Travel Grant Award 2010, Society of Vascular and Interventional Neurology (SVIN) 3rd Annual Meeting
- American Academy of Neurology Institutes (AANI) Annual Meeting Fellow Scholarship 2012, The 64th Annual meeting of AAN
Chapter 8 Acute Stroke Evaluation and Management. in Emergency Neurology.
Ty Shang, Dileep Yavagal, Jose Romano, Ralph Sacco (2012), New York, Springer
- Chapter 8 Acute Stroke Evaluation and Management. in Emergency Neurology.
1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3.
Shang T, Uihlein AV, Van Asten J, Kalyanaraman B, Hillard CJ Journal of neurochemistry 2003 Apr 85 2 358-67
Application of acute stroke imaging: Selecting patients for revascularization therapy.
Shang T, Yavagal DR Neurology 2012 Sep 79 13 Suppl 1 S86-94
FLAIR Distal Hyperintense Vessels as a Marker of Perfusion-Diffusion Mismatch in Acute Stroke.
Haussen DC, Koch S, Saraf-Lavi E, Shang T, Dharmadhikari S, Yavagal DR Journal of neuroimaging : official journal of the American Society of Neuroimaging 2013 Jan
Death-associated protein kinase as a sensor of mitochondrial membrane potential: role of lysosome in mitochondrial toxin-induced cell death.
Shang T, Joseph J, Hillard CJ, Kalyanaraman B The Journal of biological chemistry 2005 Oct 280 41 34644-53
JC virus granule cell neuronopathy and hyper-IgE in HIV disease.
Shang T, Delgado A, Adams D Neurology 2011 May 76 22 1941-2
Cerebral hemodynamics and cognitive performance in bilateral asymptomatic carotid stenosis.
Shang T Neurology 2013 May 80 22 2080
Letter by Shang Regarding Article, "Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation"
Shang T Stroke; a journal of cerebral circulation 2014 Aug
Differences in lipid profiles in two Hispanic ischemic stroke populations.
Arauz A, Romano JG, Ruiz-Franco A, Shang T, Dong C, Rundek T, Koch S, Hernández-Curiel B, Pacheco J, Rojas P, Ruiz-Navarro F, Katsnelson M, Sacco RL International journal of stroke : official journal of the International Stroke Society 2014 Jun 9 4 394-9
Bilateral Asymmetrical Asterixis as Limb-shaking Transient Ischemic Attack in Bilateral Carotid Stenosis.
Khan S, Chang E, Saniuk G, Shang T Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2014 Nov
Letter by Shang et al Regarding Article, "High-Resolution Magnetic Resonance Wall Imaging Findings of Moyamoya Disease"
Shang T, Welch B, Pinho M Stroke; a journal of cerebral circulation 2014 Oct
Endovascular Therapy for Acute Ischemic Stroke: Dawn of a New Era.
Alberts MJ, Shang T, Magadan A JAMA neurology 2015 Aug
Nitric oxide, proteasomal function, and iron homeostasis--implications in aging and neurodegenerative diseases.
Kotamraju S, Kalivendi S, Shang T, Kalyanaraman B, Methods in enzymology 2005 396 526-34
Clinical Reasoning: A 76-year-old man with acute-onset left-sided weakness and numbness.
Renthal W, Alberts M, Shang T Neurology 2016 Apr 86 15 e156-60
P MRS in the human brain at 7T.
Ren J, Shang T, Sherry AD, Malloy CR Magnetic resonance in medicine 2018 Feb
Intracranial Vessel Wall MRI in Clinical Practice ? technical considerations, current and emerging applications, clinical pearls and pitfalls
Pinho MC, Hall JT, Cross JC, Shang T, Madhuranthakam AJ, and Moore WA Neurographics 2018 8 2 97-118
Impaired cerebral autoregulation: measurement and application to stroke.
Xiong L, Liu X, Shang T, Smielewski P, Donnelly J, Guo ZN, Yang Y, Leung T, Czosnyka M, Zhang R, Liu J, Wong KS Journal of neurology, neurosurgery, and psychiatry 2017 Jun 88 6 520-531
Upregulation of immunoproteasomes by nitric oxide: potential antioxidative mechanism in endothelial cells.
Kotamraju S, Matalon S, Matsunaga T, Shang T, Hickman-Davis JM, Kalyanaraman B, Free radical biology & medicine 2006 Mar 40 6 1034-44
Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: role of tetrahydrobiopterin, nitric oxide, and proteasome activation.
Shang T, Kotamraju S, Zhao H, Kalivendi SV, Hillard CJ, Kalyanaraman B, Free radical biology & medicine 2005 Oct 39 8 1059-74
Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis.
Dhanasekaran A, Kotamraju S, Kalivendi SV, Matsunaga T, Shang T, Keszler A, Joseph J, Kalyanaraman B, The Journal of biological chemistry 2004 Sep 279 36 37575-87
1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide.
Shang T, Kotamraju S, Kalivendi SV, Hillard CJ, Kalyanaraman B, The Journal of biological chemistry 2004 Apr 279 18 19099-112
Prevalence of and Risk Factors for Cerebral Microbleeds in Moyamoya Disease and Syndrome in the American Population.
Khan NI, Saherwala AA, Chen M, Salehian S, Salahuddin H, Welch BG, Pinho MC, Shang T, Cerebrovascular diseases extra 2019 Dec 9 3 139-147
- 1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3.
- Small vessel disease and neurovascular unit
- Progressive multifocal leukoencephalopathy in HIV disease
- Posterior Reversible Encephalopathy Syndrome & Reversible Cerebral Vasoconstriction Syndrome
- Penumbra evolution in ischemic stroke
- Moyamoya disease and Moyamoya syndrome
- Hemorrhagic transformation in ischemic stroke
- Delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage
- Cerebral edema in malignant infarct
- Cerebrovascular Disease
Q&A by Dr. Shang
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