V. Vinod Mootha, M.D.

Paul T. Stoffel / Centex Professorship in Clinical Care

Ophthalmology
Cornea & External Disease
Refractive & Cataract Surgery

New Patient Appointment or 214-645-2020

Biography

Vinod Mootha, M.D., is a Professor in the Department of Ophthalmology at UT Southwestern Medical Center.

He earned his medical degree at the Johns Hopkins University School of Medicine and completed a residency in ophthalmology at the University of Wisconsin. He then received advanced training in treating corneal and external eye disease and performing keratorefractive surgery through a fellowship at UT Southwestern Medical Center.

Certified by the American Board of Ophthalmology, he joined the UT Southwestern faculty in 2004.

Dr. Mootha is a member of the American Academy of Ophthalmology and the Association for Research in Vision and Ophthalmology. He received the Fifteen-Year Service Award from the Department of Ophthalmology at UT Southwestern in 2015.

Dr. Mootha has delivered scores of national and international presentations, served as principal investigator for several National Institutes of Health-funded research projects, and published numerous academic articles on corneal transplantation and Fuchs’ endothelial corneal dystrophy.

Education & Training

Fellowship - UT Southwestern Medical School (1998-1999), Cornea & External Diseases
Residency - University of Wisconsin Hospital and Clinics (1994-1997), Ophthalmology
Internship - St. Joseph's Hospital (1993-1994), Transitional Year
Medical School - Johns Hopkins University School of Medicine (1989-1993)

Professional Associations & Affiliations

Association for Research in Vision and Ophthalmology
American Academy of Ophthalmology

Honors & Awards

North & Central Texas Clinical and Translational Science Initiative 2010, Pilot Grant Award Recipient
Cornea Society 2010, Member with thesis
D Magazine 2013, Best Doctors in Dallas

Books & Publications

Publications
- Delivery of Antisense Oligonucleotides to the Cornea.
  Chau VQ, Hu J, Gong X, Hulleman JD, Ufret-Vincenty RL, Rigo F, Prakash TP, Corey DR, Mootha VV, Nucleic acid therapeutics 2020 Mar
- Oligonucleotides Targeting TCF4 Triplet Repeat Expansion Inhibit RNA Foci and Mis-splicing in Fuchs' Dystrophy.
  Hu J, Rong Z, Gong X, Zhou Z, Sharma VK, Xing C, Watts JK, Corey DR, Mootha VV Human molecular genetics 2018 Jan
- Analyzing pre-symptomatic tissue to gain insights into the molecular and mechanistic origins of late-onset degenerative trinucleotide repeat disease.
  Chu Y, Hu J, Liang H, Kanchwala M, Xing C, Beebe W, Bowman CB, Gong X, Corey DR, Mootha VV, Nucleic acids research 2020 May
- Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy.
  Mootha VV, Hansen B, Rong Z, Mammen PP, Zhou Z, Xing C, Gong X Investigative ophthalmology & visual science 2017 Sep 58 11 4579-4585
- A novel H395R mutation in MKKS/BBS6 causes retinitis pigmentosa and polydactyly without other findings of Bardet-Biedl or McKusick-Kaufman syndrome.
  Hulleman JD, Nguyen A, Ramprasad VL, Murugan S, Gupta R, Mahindrakar A, Angara R, Sankurathri C, Mootha VV Molecular vision 2016 22 73-81
- Correlation of Severity of Fuchs Endothelial Corneal Dystrophy With Triplet Repeat Expansion in TCF4.
  Soliman AZ, Xing C, Radwan SH, Gong X, Mootha VV JAMA ophthalmology 2015 Sep 1-6
- Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
  Verhoeven VJ, Hysi PG, Wojciechowski R, Fan Q, Guggenheim JA, Höhn R, Macgregor S, Hewitt AW, Nag A, Cheng CY, Yonova-Doing E, Zhou X, Ikram MK, Buitendijk GH, McMahon G, Kemp JP, Pourcain BS, Simpson CL, Mäkelä KM, Lehtimäki T, Kähönen M, Paterson AD, Hosseini SM, Wong HS, Xu L, Jonas JB, Pärssinen O, Wedenoja J, Yip SP, Ho DW, Pang CP, Chen LJ, Burdon KP, Craig JE, Klein BE, Klein R, Haller T, Metspalu A, Khor CC, Tai ES, Aung T, Vithana E, Tay WT, Barathi VA, Chen P, Li R, Liao J, Zheng Y, Ong RT, Döring A, Evans DM, Timpson NJ, Verkerk AJ, Meitinger T, Raitakari O, Hawthorne F, Spector TD, Karssen LC, Pirastu M, Murgia F, Ang W, Mishra A, Montgomery GW, Pennell CE, Cumberland PM, Cotlarciuc I, Mitchell P, Wang JJ, Schache M, Janmahasathian S, Jr RP, Lass JH, Chew E, Iyengar SK, Gorgels TG, Rudan I, Hayward C, Wright AF, Polasek O, Vatavuk Z, Wilson JF, Fleck B, Zeller T, Mirshahi A, Müller C, Uitterlinden AG, Rivadeneira F, Vingerling JR, Hofman A, Oostra BA, Amin N, Bergen AA, Teo YY, Rahi JS, Vitart V, Williams C, Baird PN, Wong TY, Oexle K, Pfeiffer N, Mackey DA, Young TL, van Duijn CM, Saw SM, Bailey-Wilson JE, Stambolian D, Klaver CC, Hammond CJ Nature genetics 2013 Mar 45 3 314-8
- Association of Smoking and Other Risk Factors with Fuchs' Endothelial Corneal Dystrophy Severity and Corneal Thickness.
  Zhang X, Igo RP, Fondran JR, Mootha VV, Oliva M, Hammersmith K, Sugar A, Lass JH, Iyengar SK Investigative ophthalmology & visual science 2013 Jul
- Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
  Cheng CY, Schache M, Ikram MK, Young TL, Guggenheim JA, Vitart V, MacGregor S, Verhoeven VJ, Barathi VA, Liao J, Hysi PG, Bailey-Wilson JE, St Pourcain B, Kemp JP, McMahon G, Timpson NJ, Evans DM, Montgomery GW, Mishra A, Wang YX, Wang JJ, Rochtchina E, Polasek O, Wright AF, Amin N, van Leeuwen EM, Wilson JF, Pennell CE, van Duijn CM, de Jong PT, Vingerling JR, Zhou X, Chen P, Li R, Tay WT, Zheng Y, Chew M, Burdon KP, Craig JE, Iyengar SK, Igo RP, Lass JH, Chew EY, Haller T, Mihailov E, Metspalu A, Wedenoja J, Simpson CL, Wojciechowski R, Höhn R, Mirshahi A, Zeller T, Pfeiffer N, Lackner KJ, Bettecken T, Meitinger T, Oexle K, Pirastu M, Portas L, Nag A, Williams KM, Yonova-Doing E, Klein R, Klein BE, Hosseini SM, Paterson AD, Makela KM, Lehtimaki T, Kahonen M, Raitakari O, Yoshimura N, Matsuda F, Chen LJ, Pang CP, Yip SP, Yap MK, Meguro A, Mizuki N, Inoko H, Foster PJ, Zhao JH, Vithana E, Tai ES, Fan Q, Xu L, Campbell H, Fleck B, Rudan I, Aung T, Hofman A, Uitterlinden AG, Bencic G, Khor CC, Forward H, Pärssinen O, Mitchell P, Rivadeneira F, Hewitt AW, Williams C, Oostra BA, Teo YY, Hammond CJ, Stambolian D, Mackey DA, Klaver CC, Wong TY, Saw SM, Baird PN American journal of human genetics 2013 Aug 93 2 264-77
- Histopathology and spectral domain OCT findings of pneumatic-assisted dissection in DALK.
  Kim SY, Muftuoglu O, Hogan RN, Bowman RW, Cavanagh HD, McCulley JP, Mootha VV Cornea 2012 Nov 31 11 1288-93
- Differing roles for TCF4 and COL8A2 in central corneal thickness and fuchs endothelial corneal dystrophy.
  Igo RP, Kopplin LJ, Joseph P, Truitt B, Fondran J, Bardenstein D, Aldave AJ, Croasdale CR, Price MO, Rosenwasser M, Lass JH, Iyengar SK PloS one 2012 7 10 e46742
- Comparative study of descemet stripping automated endothelial keratoplasty donor preparation by Moria CBm microkeratome, horizon microkeratome, and Intralase FS60.
  Mootha VV, Heck E, Verity SM, Petroll WM, Lakshman N, Muftuoglu O, Bowman RW, McCulley JP, Cavanagh HD Cornea 2011 Mar 30 3 320-4
- Incidence of and risk factors for residual posterior capsule opacification after cataract surgery.
  Mootha VV, Tesser R, Qualls C Journal of cataract and refractive surgery 2004 Nov 30 11 2354-8
- Slitlamp, specular, and light microscopic findings of human donor corneas after laser-assisted in situ keratomileusis.
  Mootha VV, Dawson D, Kumar A, Gleiser J, Qualls C, Albert DM Archives of ophthalmology 2004 May 122 5 686-92
- Nematode in the anterior chamber.
  Ogirala GK, Raju VK, Pradesh A, Davids HR, Mootha VV Archives of ophthalmology 2003 Sep 121 9 1338-9
- Evaluation of the role of ProKera in the management of ocular surface and orbital disorders.
  Pachigolla G, Prasher P, Di Pascuale MA, McCulley JP, McHenry JG, Mootha VV Eye & contact lens 2009 Jul 35 4 172-5
- Association and Familial Segregation of CTG18.1 Trinucleotide Repeat Expansion of TCF4 Gene in Fuchs' Endothelial Corneal Dystrophy.
  Mootha VV, Gong X, Ku HC, Xing C Investigative ophthalmology & visual science 2013 Nov
- Relationship Between Fuchs Endothelial Corneal Dystrophy Severity and Glaucoma and/or Ocular Hypertension.
  Nagarsheth M, Singh A, Schmotzer B, Babineau DC, Sugar J, Lee WB, Iyengar SK, Lass JH Archives of ophthalmology (Chicago, Ill. : 1960) 2012 Nov 130 11 1384-8
- Risk factors for intraocular pressure elevation after descemet stripping automated endothelial keratoplasty.
  Allen MB, Lieu P, Mootha VV, Bowman RW, Petroll WM, Tong L, Kooner KS, Cavanagh HD, Whitson JT, Aggarwal NK Eye & contact lens 2010 Jul 36 4 223-7
- Intraocular hemorrhages due to warfarin fluconazole drug interaction in a patient with presumed Candida endophthalmitis.
  Mootha VV, Schluter ML, Das A Archives of ophthalmology 2002 Jan 120 1 94-5
- Exome sequencing reveals novel homozygous FOXE3 mutation in microphthalmos with staphylomatous malformation.
  Saboo US, Penke D, Mahindrakar A, Uddaraju M, Sankurathri C, Gong X, Xing C, Mootha VV Ophthalmic genetics 2016 Sep 1-3
- Corneal deturgescence after Descemet stripping automated endothelial keratoplasty evaluated by Visante anterior segment optical coherence tomography.
  Di Pascuale MA, Prasher P, Schlecte C, Arey M, Bowman RW, Cavanagh HD, McCulley JP, Mootha VV American journal of ophthalmology 2009 Jul 148 1 32-7.e1
- Shifting bubble sign, a useful tip in manual dissection of deep anterior lamellar keratoplasty
  Niknam S, Rajabi MT, Mootha VV, Shahrzad SS, Rajabi MB, Zazhi GY International Journal of Ophthalmology 2011 3 11 388-389
- Effect of systane and optive on aqueous tear evaporation in patients with dry eye disease.
  Wojtowicz JC, Arciniega JC, McCulley JP, Mootha VV Eye & contact lens 2010 Nov 36 6 358-60
- Apodized diffractive intraocular lens implantation after laser in situ keratomileusis with or without subsequent excimer laser enhancement.
  Muftuoglu O, Dao L, Mootha VV, Verity SM, Bowman RW, Cavanagh HD, McCulley JP Journal of cataract and refractive surgery 2010 Nov 36 11 1815-21
- Intraocular lens power calculation after myopic laser in situ keratomileusis: Estimating the corneal refractive power.
  Awwad ST, Manasseh C, Bowman RW, Cavanagh HD, Verity S, Mootha V, McCulley JP Journal of cataract and refractive surgery 2008 Jul 34 7 1070-6
- Marked reduction of alcohol dehydrogenase in keratoconus corneal fibroblasts.
  Mootha VV, Kanoff JM, Shankardas J, Dimitrijevich S Molecular vision 2009 15 706-12
- Slit-lamp, confocal, and light microscopic findings of corneal siderosis.
  Witherspoon SR, Hogan RN, Petroll WM, Mootha VV Cornea 2007 Dec 26 10 1270-2
- Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy.
  Afshari NA, Igo RP, Morris NJ, Stambolian D, Sharma S, Pulagam VL, Dunn S, Stamler JF, Truitt BJ, Rimmler J, Kuot A, Croasdale CR, Qin X, Burdon KP, Riazuddin SA, Mills R, Klebe S, Minear MA, Zhao J, Balajonda E, Rosenwasser GO, Baratz KH, Mootha VV, Patel SV, Gregory SG, Bailey-Wilson JE, Price MO, Price FW, Craig JE, Fingert JH, Gottsch JD, Aldave AJ, Klintworth GK, Lass JH, Li YJ, Iyengar SK Nature communications 2017 Mar 8 14898
- Congenital Corneal Endothelial Dystrophies Resulting From Novel De Novo Mutations.
  Cunnusamy K, Bowman CB, Beebe W, Gong X, Hogan RN, Mootha VV Cornea 2016 Feb 35 2 281-5
- A novel de novo KIF21A mutation in a patient with congenital fibrosis of the extraocular muscles and Möbius syndrome.
  Ali Z, Xing C, Anwar D, Itani K, Weakley D, Gong X, Pascual JM, Mootha VV Molecular vision 2014 20 368-75
- Sarnicola Air-Visco Bubble Technique in Deep Anterior Lamellar Keratoplasty.
  Muftuoglu O, Toro P, Hogan RN, Bowman RW, Cavanagh HD, McCulley JP, Mootha VV, Sarnicola V Cornea 2012 Nov
- Relationship of Fuchs endothelial corneal dystrophy severity to central corneal thickness.
  Kopplin LJ, Przepyszny K, Schmotzer B, Rudo K, Babineau DC, Patel SV, Verdier DD, Jurkunas U, Iyengar SK, Lass JH Archives of ophthalmology (Chicago, Ill. : 1960) 2012 Apr 130 4 433-9
- Comparative Study of Descemet Stripping Automated Endothelial Keratoplasty Donor Preparation by Moria CBm Microkeratome, Horizon Microkeratome, and Intralase FS60.
  Mootha VV, Heck E, Verity SM, Petroll WM, Lakshman N, Muftuoglu O, Bowman RW, McCulley JP, Cavanagh HD Cornea 2010 Nov
- Corneal melting after use of nepafenac in a patient with chronic cystoid macular edema after cataract surgery.
  Di Pascuale MA, Whitson JT, Mootha VV Eye & contact lens 2008 Mar 34 2 129-30
- Advanced keratomalacia with descemetocele in an infant with cystic fibrosis.
  Wamsley S, Patel SM, Wood MG, Villalobos R, Albert DM, Mootha VV Archives of ophthalmology 2005 Jul 123 7 1012-6
- Descemet's Stripping Automated Endothelial Keratoplasty Tissue Insertion Devices.
  Khan SN, Shiakolas PS, Mootha VV Journal of ophthalmic & vision research 2015 Oct-Dec 10 4 461-8
- Impact of Donor Age on Corneal Endothelium-Descemet Membrane Layer Scroll Formation.
  Bennett A, Mahmoud S, Drury D, Cavanagh HD, McCulley JP, Petroll WM, Mootha VV Eye & contact lens 2015 Jan
- TCF4 Triplet Repeat Expansion and Nuclear RNA Foci in Fuchs' Endothelial Corneal Dystrophy.
  Mootha VV, Hussain I, Cunnusamy K, Graham E, Gong X, Neelam S, Xing C, Kittler R, Petroll WM Investigative ophthalmology & visual science 2015 Feb
- Blunt scissors stromal dissection technique for deep anterior lamellar keratoplasty.
  Anwar DS, Kruger MM, Mootha VV Clinical ophthalmology (Auckland, N.Z.) 2014 8 1849-54
- Features of Urrets-Zavalia syndrome after descemet stripping automated endothelial keratoplasty.
  Anwar DS, Chu CY, Prasher P, Bowman RW, Mootha VV Cornea 2012 Nov 31 11 1330-4
- Traumatic graft dehiscence after anterior lamellar keratoplasty.
  Prasher P, Muftuoglu O, Mootha VV Cornea 2009 Feb 28 2 240-2
- Subperiosteal orbital hemorrhage from retrobulbar injection resulting in blindness.
  Mootha VV, Cowden TP, Sires BS, Dortzbach RK Archives of ophthalmology 1997 Jan 115 1 123-4
- Trans-ethnic Replication of Association of CTG18.1 Repeat Expansion of TCF4 Gene with Fuchs Corneal Dystrophy in Chinese Implies Common Causal Variant.
  Xing C, Gong X, Hussain I, Khor CC, Tan DT, Aung T, Mehta JS, Vithana EN, Mootha VV Investigative ophthalmology & visual science 2014 Oct
- Identification problems with sterile fungi, illustrated by a keratitis due to a non-sporulating Chaetomium-like species.
  Vinod Mootha V, Shahinpoor P, Sutton DA, Xin L, Najafzadeh MJ, de Hoog GS Medical mycology 2012 May 50 4 361-7
- Glaucoma in patients with corneal endothelial dystrophy.
  Ali ZK, Whitson JT, Mootha VV, Witherspoon SR, Joseph JA, Joseph AM, Hynan LS, Cavanagh HD Eye & contact lens 2011 Nov 37 6 332-6
- Corneal power measurement with a rotating Scheimpflug imaging system after Descemet-stripping automated endothelial keratoplasty.
  Prasher P, Muftuoglu O, Bowman RW, Cavanagh HD, McCulley JP, Mootha VV Journal of cataract and refractive surgery 2010 Aug 36 8 1358-64
- Laser in situ keratomileusis for residual refractive errors after apodized diffractive multifocal intraocular lens implantation.
  Muftuoglu O, Prasher P, Chu C, Mootha VV, Verity SM, Cavanagh HD, Bowman RW, McCulley JP Journal of cataract and refractive surgery 2009 Jun 35 6 1063-71
- Tandem scanning confocal microscopy of cornea after descemet stripping automated endothelial keratoplasty.
  Prasher P, Muftuoglu O, Bowman RW, McCulley JP, Petroll WM, Cavanagh HD, Mootha VV Eye & contact lens 2009 Jul 35 4 196-202
- First report of traumatic globe rupture after femtosecond laser-assisted penetrating keratoplasty.
  Kruger MM, Mootha VV Cornea 2012 Dec 31 12 1504-6
- Mucous membrane pemphigoid with fatal bronchial involvement in a seventeen-year-old girl.
  Gamm DM, Harris A, Mehran RJ, Wood M, Foster CS, Mootha VV Cornea 2006 May 25 4 474-8
- Corneal higher-order aberrations after Descemet's stripping automated endothelial keratoplasty.
  Muftuoglu O, Prasher P, Bowman RW, McCulley JP, Mootha VV Ophthalmology 2010 May 117 5 878-884.e6
- Assessment of keratocyte activation following LASIK with flap creation using the IntraLase FS60 laser.
  Petroll WM, Bowman RW, Cavanagh HD, Verity SM, Mootha VV, McCulley JP Journal of refractive surgery (Thorofare, N.J. : 1995) 2008 Oct 24 8 847-9
- Computed tomography in the diagnosis of occult open-globe injuries.
  Arey ML, Mootha VV, Whittemore AR, Chason DP, Blomquist PH Ophthalmology 2007 Aug 114 8 1448-52
- Corneal thickness association with ocular and corneal high-order aberrations.
  Mohamed EM, Wojtowicz JC, Bowman W, Cavanagh HD, Mootha V, Verity S, McCulley JP Eye & contact lens 2009 Nov 35 6 297-301
- Epithelial downgrowth after descemet stripping automated endothelial keratoplasty.
  Prasher P, Muftuoglu O, Hsiao ML, Bowman RW, Hogan RN, Mootha VV Cornea 2009 Jul 28 6 708-11
- Intraocular lens power calculation after radial keratotomy: estimating the refractive corneal power.
  Awwad ST, Dwarakanathan S, Bowman RW, Cavanagh HD, Verity SM, Mootha VV, McCulley JP Journal of cataract and refractive surgery 2007 Jun 33 6 1045-50
- Bilateral keratoconjunctivitis associated with lichen planus.
  Rhee MK, Mootha VV Cornea 2004 Jan 23 1 100-5
- Pterygia with deep corneal changes.
  Mootha VV, Pingree M, Jaramillo J Cornea 2004 Aug 23 6 635-8
- Postprandial transient visual loss. A symptom of critical carotid stenosis.
  Levin LA, Mootha VV Ophthalmology 1997 Mar 104 3 397-401
- Wavefront-guided ablation retreatment using Iris registration.
  Mohamed EM, Muftuoglu O, Bowman W, Cavanagh HD, Mootha VV, Radwan GA, McCulley JP Eye & contact lens 2010 Jan 36 1 54-9
- Microbial keratitis identified during eye bank screen of corneoscleral tissue harvested from patients with laser in situ keratomileusis history.
  Mootha VV, Dawson D, Kumar A, Gleiser J, Albert DM Archives of ophthalmology 2004 Jul 122 7 1058-60
- Comparison of the corneal response to laser in situ keratomileusis with flap creation using the FS15 and FS30 femtosecond lasers: clinical and confocal microscopy findings.
  Hu MY, McCulley JP, Cavanagh HD, Bowman RW, Verity SM, Mootha VV, Petroll WM Journal of cataract and refractive surgery 2007 Apr 33 4 673-81

Research

Genetics of corneal disorders
Fuchs' Endothelial Corneal Dystrophy
Endothelial keratoplasty
Cataract surgery

Clinical Focus

Cornea & External Disease
Refractive & Cataract Surgery
Comprehensive Ophthalmology
Cataracts

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