MDS Symptoms
Because failure of the bone marrow to produce normal mature cells is a slow process, MDS might not cause symptoms in its early stages.
As the disease progresses, patients might experience:
- Fatigue
- Recurrent infections, due to leukopenia (low white blood cell count)
- Shortness of breath or unusual paleness, due to anemia (low red blood cell count)
- Easy or abnormal bruising or bleeding, due to thrombocytopenia (low blood platelet count)
- Enlargement of the liver or spleen (for MDS/MPN)
Diagnosing MDS
At UT Southwestern, our blood cancer specialists have the expertise to diagnosis MDS, MDS/MPN, or CMML quickly and accurately. We begin with a review of a patient’s medical history, a discussion of symptoms, and a thorough physical exam.
To confirm a diagnosis, we might recommend additional tests, such as:
- Blood tests: Tests that identify the number of red cells, white cells, and platelets and look for changes in the appearance of various blood cells
- Bone marrow aspirate and biopsy: Removal of a small amount of liquid bone marrow and piece of bone, typically from the hipbone, to look for specific abnormalities
Treatment for MDS
Treatment for MDS, MDS/MPN, or CMML depends on the severity and symptoms of the disease. Our recommended approach might include:
- Watching and waiting, with regular lab tests and exams
- Slowing the progression of the disease
- Managing symptoms
- Preventing complications such as infections or bleeding
At UT Southwestern, we have expertise in using the most advanced treatments for MDS, overlap disorders, or CMML, including:
- Blood transfusions to replace red blood cells or platelets
- Medications with the goal of increasing the number of blood cells, suppressing the immune system, stimulating blood cells to mature, or treating infections
- Bone marrow transplant to replace abnormal bone marrow stem cells with healthy, donated cells
Support During and After Treatment
Our care teams offer nutritional, spiritual, and transitional guidance from the start of a patient’s journey, through treatment, and beyond. The overall physical and emotional well-being of our patients is vital to achieving a positive outcome. Learn more about our support services.