- Fellowship - Cleveland Clinic Foundation (2013-2014), Epilepsy
- Residency - University of Pennsylvania (2007-2013), Neurological Surgery
- Internship - University of Pennsylvania Health System (2006-2007), General Surgery
- Medical School - Baylor College of Medicine (2002-2006)
Bradley Lega, M.D.
- Neurological Surgery
Dr. Lega earned his undergraduate degree at Rice University and his medical degree at Baylor College of Medicine. He completed his neurological surgery residency at the University of Pennsylvania and received advanced training through a fellowship in epilepsy surgery at the Cleveland Clinic.
He offers patients access to emerging techniques for the treatment of epilepsy, brain tumors, and disorders of the spine. His area of specialty includes using novel brain mapping and computer-assisted navigation technologies to improve the safety and efficacy of neurosurgical procedures.
During his fellowship training at the Cleveland Clinic, Dr. Lega gained expertise in the use of stereo EEG, a technique used to identify whether patients with epilepsy are candidates for surgical treatment. He is one of only a handful of neurosurgeons in the country using this technique.
Dr. Lega’s research focuses on how brain conditions affect memory. The research he began at the University of Pennsylvania and that he continues at UT Southwestern focuses on preserving memory function and restoring memory to patients with brain injuries or brain tumors.
He is a member of several professional organizations, including the American Association of Neurological Surgeons, the Congress of Neurological Surgeons, and the Society for Neuroscience.
Meet Dr. Lega
As the surgical leader of UT Southwestern Medical Center’s comprehensive epilepsy program, one of the top programs in the world, Dr. Lega is recognized as a national expert in using stereoelectroencephalography, or stereo EEG to locate the origin of epileptic seizures in the brain. This can then help determine if a patient is a candidate for surgical treatment.
Revolutionizing Treatment Using Emerging Technologies
Through experience acquired through hundreds of epilepsy and tumor cases, Dr. Lega tailors his mapping and treatment strategies to the unique circumstances of each patient. This includes using new, less invasive techniques along with traditional surgical approaches.
“It’s an exciting time to be working in this field,” Dr. Lega says. “New tools, such as stereo EEG and NeuroPace, are giving options to patients who may have previously been told surgical treatments weren’t available to them. And laser interstitial therapy (LITT) has given us a less invasive option that is ideally suited to treating some patients with epilepsy and tumors.”
LITT is only available at UT Southwestern through Southwest Health Resources, and Dr. Lega is the only surgeon in North Texas who provides this therapy to patients with brain tumors and epilepsy.
“Laser therapy requires an expert team working together, and the close collaborative environment at UT Southwestern is really necessary for these complex cases. Brain tumors are often linked to seizures, and our integrated team provides the best approach for their treatment.”
This integrated approach also helps protect the brain’s vital functions, including memory, during a patient's treatment for tumors and epilepsy.
“Our team at UT Southwestern works with a group of leading centers across the country to understand memory and other cognitive functions, such as language processing. Our work has led to exciting breakthroughs,” Dr. Lega says.
Dr. Lega has been widely recognized for his contributions to understanding how the brain creates memories. “One day, we hope to restore memory function to patients in whom tumors or epilepsy have affected their brain. For now, this work has given me a deep understanding of how best to preserve these vital functions for patients who need surgery,” Dr. Lega says.
“With the tools we have at UT Southwestern, the expertise of our team, and our experience as one of the busiest centers in the country, I am proud to say that the care we provide patients with these conditions is truly top notch.”
- American Association of Neurological Surgeons (2017-2018)
- Cognitive Neuroscience Society (2012-2018)
- Congress of Neurological Surgeons (2012-2018)
- Society for Neuroscience (2011-2018)
An essay concerning human understanding: how the cerebri anatome of Thomas Willis influenced John Locke.
Lega BC Neurosurgery 2006 Mar 58 3 567-76; discussion 567-76
Postoperative dural sinus thrombosis in a patient in a hypercoagulable state. Case report.
Lega BC, Yoshor D Journal of neurosurgery 2006 Nov 105 5 772-4
Recurrent hemifacial spasm following minor trauma: report of a case.
Lega BC, Harper RL, Dannenbaum MD, Yoshor D Stereotactic and functional neurosurgery 2008 86 6 394-6
Local cortical function after uncomplicated subdural electrode implantation. Laboratory investigation.
Yoshor D, Bosking WH, Lega BC, Sun P, Maunsell JH Journal of neurosurgery 2008 Jan 108 1 139-44
Microvascular decompression for hemifacial spasm: long-term results from 114 operations performed without neurophysiological monitoring.
Dannenbaum M, Lega BC, Suki D, Harper RL, Yoshor D Journal of neurosurgery 2008 Sep 109 3 410-5
Quality of life after hemicraniectomy for traumatic brain injury in adults. A review of the literature.
Danish SF, Barone D, Lega BC, Stein SC Neurosurgical focus 2009 Jun 26 6 E2
Cortical resection tailored to awake, intraoperative ictal recordings and motor mapping in the treatment of intractable epilepsia partialis continua: technical case report.
Lega BC, Wilfong AA, Goldsmith IL, Verma A, Yoshor D Neurosurgery 2009 Mar 64 3 Suppl ons195-6; discussion ons196
Isolated lower extremity monoplegia due to a traumatic intraparenchymal contusion: report of two cases.
Lega BC, Bailey RL, Kramer DR, Heuer GG, Chen JY, Schuster JM Brain injury : [BI] 2010 24 10 1231-5
Deep brain stimulation in the treatment of refractory epilepsy: update on current data and future directions.
Lega BC, Halpern CH, Jaggi JL, Baltuch GH Neurobiology of disease 2010 Jun 38 3 354-60
Choosing the best operation for chronic subdural hematoma: a decision analysis.
Lega BC, Danish SF, Malhotra NR, Sonnad SS, Stein SC Journal of neurosurgery 2010 Sep 113 3 615-21
Brain-machine interfaces: electrophysiological challenges and limitations.
Lega BC, Serruya MD, Zaghloul KA Critical reviews in biomedical engineering 2011 39 1 5-28
A patient with thoracic intradural disc herniation.
Whitmore RG, Williams BJ, Lega BC, Sanborn MR, Marcotte P Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2011 Dec 18 12 1730-2
Morphometric measurements of the anterior skull base for endoscopic transoral and transnasal approaches.
Lega BC, Kramer DR, Newman JG, Lee JY Skull base : official journal of North American Skull Base Society ... [et al.] 2011 Jan 21 1 65-70
Neuronal and oscillatory activity during reward processing in the human ventral striatum.
Lega BC, Kahana MJ, Jaggi J, Baltuch GH, Zaghloul K Neuroreport 2011 Nov 22 16 795-800
Human hippocampal theta oscillations and the formation of episodic memories.
Lega BC, Jacobs J, Kahana M Hippocampus 2012 Apr 22 4 748-61
Neuronal activity in the human subthalamic nucleus encodes decision conflict during action selection.
Zaghloul KA, Weidemann CT, Lega BC, Jaggi JL, Baltuch GH, Kahana MJ The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Feb 32 7 2453-60
Hemispheric malformations of cortical development: surgical indications and approach.
Lega B, Mullin J, Wyllie E, Bingaman W Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2014 Nov 30 11 1831-7
Slow-Theta-to-Gamma Phase-Amplitude Coupling in Human Hippocampus Supports the Formation of New Episodic Memories.
Lega B, Burke J, Jacobs J, Kahana MJ Cerebral cortex (New York, N.Y. : 1991) 2014 Oct
The gamma band effect for episodic memory encoding is absent in epileptogenic hippocampi.
Lega B, Dionisio S, Bingaman W, Najm I, Gonzalez-Martinez J Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2014 Sep
Theta band power increases in the posterior hippocampus predict successful episodic memory encoding in humans.
Lin JJ, Rugg MD, Das S, Stein J, Rizzuto DS, Kahana MJ, Lega BC Hippocampus 2017 Jun
Contextually Mediated Spontaneous Retrieval Is Specific to the Hippocampus.
Long NM, Sperling MR, Worrell GA, Davis KA, Gross RE, Lega BC, Jobst BC, Sheth SA, Zaghloul K, Stein JM, Kahana MJ Current biology : CB 2017 Mar
Comparison of logistic regression, support vector machines, and deep learning classifiers for predicting memory encoding success using human intracranial EEG recordings.
Arora A, Lin JJ, Gasperian A, Maldjian J, Stein J, Kahana M, Lega B, Journal of neural engineering 2018 12 15 6 066028
Closed-loop stimulation of temporal cortex rescues functional networks and improves memory.
Ezzyat Y, Wanda PA, Levy DF, Kadel A, Aka A, Pedisich I, Sperling MR, Sharan AD, Lega BC, Burks A, Gross RE, Inman CS, Jobst BC, Gorenstein MA, Davis KA, Worrell GA, Kucewicz MT, Stein JM, Gorniak R, Das SR, Rizzuto DS, Kahana MJ Nature communications 2018 Feb 9 1 365
Electrophysiological signatures of spatial boundaries in the human subiculum.
Ah Lee S, Miller JF, Watrous AJ, Sperling MR, Sharan A, Worrell GA, Berry BM, Aronson JP, Davis KA, Gross RE, Lega B, Sheth S, Das SR, Stein JM, Gorniak R, Rizzuto DS, Jacobs J The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Feb
Methylation of hypoxia-inducible factor (HIF)-1a by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration.
Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, Semenza GL, Wang Y, Luo W Nucleic acids research 2018 May
Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding.
Waldman ZJ, Camarillo-Rodriguez L, Chervenova I, Berry B, Shimamoto S, Elahian B, Kucewicz M, Ganne C, He XS, Davis LA, Stein J, Das S, Gorniak R, Sharan AD, Gross R, Inman CS, Lega BC, Zaghloul K, Jobst BC, Davis KA, Wanda P, Khadjevand M, Tracy J, Rizzuto DS, Worrell G, Sperling M, Weiss SA Epilepsy & behavior : E&B 2018 Sep 88 33-40
Functional control of electrophysiological network architecture using direct neurostimulation in humans.
Khambhati AN, Kahn AE, Costantini J, Ezzyat Y, Solomon EA, Gross RE, Jobst BC, Sheth SA, Zaghloul KA, Worrell G, Seger S, Lega BC, Weiss S, Sperling MR, Gorniak R, Das SR, Stein JM, Rizzuto DS, Kahana MJ, Lucas TH, Davis KA, Tracy JI, Bassett DS, Network neuroscience (Cambridge, Mass.) 2019 3 3 848-877
Stimulation of the Posterior Cingulate Cortex Impairs Episodic Memory Encoding.
Natu VS, Lin JJ, Burks A, Arora A, Rugg MD, Lega B, The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 09 39 36 7173-7182
Risk of seizures induced by intracranial research stimulation: analysis of 770 stimulation sessions.
Goldstein HE, Smith EH, Gross RE, Jobst BC, Lega BC, Sperling MR, Worrell GA, Zaghloul KA, Wanda PA, Kahana MJ, Rizzuto DS, Schevon CA, McKhann GM, Sheth SA, Journal of neural engineering 2019 11 16 6 066039
Connectivity of the human insula: A cortico-cortical evoked potential (CCEP) study.
Dionisio S, Mayoglou L, Cho SM, Prime D, Flanigan PM, Lega B, Mosher J, Leahy R, Gonzalez-Martinez J, Nair D, Cortex; a journal devoted to the study of the nervous system and behavior 2019 11 120 419-442
Hippocampal theta codes for distances in semantic and temporal spaces.
Solomon EA, Lega BC, Sperling MR, Kahana MJ, Proceedings of the National Academy of Sciences of the United States of America 2019 11 116 48 24343-24352
Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex.
Qasim SE, Miller J, Inman CS, Gross RE, Willie JT, Lega B, Lin JJ, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Stein JM, Jacobs J, Nature neuroscience 2019 12 22 12 2078-2086
Neural activity reveals interactions between episodic and semantic memory systems during retrieval.
Weidemann CT, Kragel JE, Lega BC, Worrell GA, Sperling MR, Sharan AD, Jobst BC, Khadjevand F, Davis KA, Wanda PA, Kadel A, Rizzuto DS, Kahana MJ Journal of experimental psychology. General 2019 Jan 148 1 1-12
Auto-fluorescence Technology in Glioblastoma Resection: The Evolution of a New Tool and Approach.
El Ahmadieh TY, Aoun SG, Lega BC, World neurosurgery 2019 Mar
Human Genomic Signatures of Brain Oscillations During Memory Encoding.
Berto S, Wang GZ, Germi J, Lega BC, Konopka G Cerebral cortex (New York, N.Y. : 1991) 2017 Apr 1-16
Longitudinal Differences in Human Hippocampal Connectivity During Episodic Memory Processing.
Choi K, Bagen L, Robinson L, Umbach G, Rugg M, Lega B, Cerebral cortex communications 2020 1 1 tgaa010
Comparison of fMRI correlates of successful episodic memory encoding in temporal lobe epilepsy patients and healthy controls.
Hill PF, King DR, Lega BC, Rugg MD, NeuroImage 2020 02 207 116397
Functionally distinct high and low theta oscillations in the human hippocampus.
Goyal A, Miller J, Qasim SE, Watrous AJ, Zhang H, Stein JM, Inman CS, Gross RE, Willie JT, Lega B, Lin JJ, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Jacobs J, Nature communications 2020 05 11 1 2469
Commentary: Awake Craniotomy and Memory Induction Through Electrical Stimulation: Why Are Penfield's Findings Not Replicated in the Modern Era?
Kulkarni NJ, Lega BC, Neurosurgery 2020 08 87 2 E138-E139
Direct brain recordings identify hippocampal and cortical networks that distinguish successful versus failed episodic memory retrieval.
Tan RJ, Rugg MD, Lega BC, Neuropsychologia 2020 10 147 107595
Hippocampal Theta Oscillations Support Successful Associative Memory Formation.
Kota S, Rugg MD, Lega BC, The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 12 40 49 9507-9518
Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy.
Nair DR, Laxer KD, Weber PB, Murro AM, Park YD, Barkley GL, Smith BJ, Gwinn RP, Doherty MJ, Noe KH, Zimmerman RS, Bergey GK, Anderson WS, Heck C, Liu CY, Lee RW, Sadler T, Duckrow RB, Hirsch LJ, Wharen RE, Tatum W, Srinivasan S, McKhann GM, Agostini MA, Alexopoulos AV, Jobst BC, Roberts DW, Salanova V, Witt TC, Cash SS, Cole AJ, Worrell GA, Lundstrom BN, Edwards JC, Halford JJ, Spencer DC, Ernst L, Skidmore CT, Sperling MR, Miller I, Geller EB, Berg MJ, Fessler AJ, Rutecki P, Goldman AM, Mizrahi EM, Gross RE, Shields DC, Schwartz TH, Labar DR, Fountain NB, Elias WJ, Olejniczak PW, Villemarette-Pittman NR, Eisenschenk S, Roper SN, Boggs JG, Courtney TA, Sun FT, Seale CG, Miller KL, Skarpaas TL, Morrell MJ, Neurology 2020 Jul
Time cells in the human hippocampus and entorhinal cortex support episodic memory.
Umbach G, Kantak P, Jacobs J, Kahana M, Pfeiffer BE, Sperling M, Lega B, Proceedings of the National Academy of Sciences of the United States of America 2020 Oct
Maximizing the potential of social media and social networks in neurosurgery.
Ban VS, Lega B, Batjer HH World neurosurgery 2016 Mar
Unsupervised machine-learning classification of electrophysiologically active electrodes during human cognitive task performance.
Saboo KV, Varatharajah Y, Berry BM, Kremen V, Sperling MR, Davis KA, Jobst BC, Gross RE, Lega B, Sheth SA, Worrell GA, Iyer RK, Kucewicz MT, Scientific reports 2019 Nov 9 1 17390
Medial temporal lobe functional connectivity predicts stimulation-induced theta power.
Solomon EA, Kragel JE, Gross R, Lega B, Sperling MR, Worrell G, Sheth SA, Zaghloul KA, Jobst BC, Stein JM, Das S, Gorniak R, Inman CS, Seger S, Rizzuto DS, Kahana MJ, Nature communications 2018 10 9 1 4437
Evidence for verbal memory enhancement with electrical brain stimulation in the lateral temporal cortex.
Kucewicz MT, Berry BM, Miller LR, Khadjevand F, Ezzyat Y, Stein JM, Kremen V, Brinkmann BH, Wanda P, Sperling MR, Gorniak R, Davis KA, Jobst BC, Gross RE, Lega B, Van Gompel J, Stead SM, Rizzuto DS, Kahana MJ, Worrell GA Brain : a journal of neurology 2018 Jan
Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation.
Miller J, Watrous AJ, Tsitsiklis M, Lee SA, Sheth SA, Schevon CA, Smith EH, Sperling MR, Sharan A, Asadi-Pooya AA, Worrell GA, Meisenhelter S, Inman CS, Davis KA, Lega B, Wanda PA, Das SR, Stein JM, Gorniak R, Jacobs J Nature communications 2018 Jun 9 1 2423
Human Verbal Memory Encoding Is Hierarchically Distributed in a Continuous Processing Stream.
Kucewicz MT, Saboo K, Berry BM, Kremen V, Miller LR, Khadjevand F, Inman CS, Wanda P, Sperling MR, Gorniak R, Davis KA, Jobst BC, Lega B, Sheth SA, Rizzuto DS, Iyer RK, Kahana MJ, Worrell GA, eNeuro 2019 Jan-Feb 6 1
Electrical Stimulation Modulates High ? Activity and Human Memory Performance.
Kucewicz MT, Berry BM, Kremen V, Miller LR, Khadjevand F, Ezzyat Y, Stein JM, Wanda P, Sperling MR, Gorniak R, Davis KA, Jobst BC, Gross RE, Lega B, Stead SM, Rizzuto DS, Kahana MJ, Worrell GA eNeuro 2018 Jan-Feb 5 1
Gamma oscillations during episodic memory processing provide evidence for functional specialization in the longitudinal axis of the human hippocampus.
Lin JJ, Umbach G, Rugg MD, Lega B, Hippocampus 2019 02 29 2 68-72
The effects of direct brain stimulation in humans depend on frequency, amplitude, and white-matter proximity.
Mohan UR, Watrous AJ, Miller JF, Lega BC, Sperling MR, Worrell GA, Gross RE, Zaghloul KA, Jobst BC, Davis KA, Sheth SA, Stein JM, Das SR, Gorniak R, Wanda PA, Rizzuto DS, Kahana MJ, Jacobs J, Brain stimulation 2020 May
Lymphomatosis Cerebri: A Diagnostic Challenge.
Hatanpaa KJ, Fuda F, Koduru P, Young K, Lega B, Chen W JAMA neurology 2015 Jul
Electrical stimulation in hippocampus and entorhinal cortex impairs spatial and temporal memory.
Goyal A, Miller J, Watrous AJ, Lee SA, Coffey T, Sperling MR, Sharan A, Worrell G, Berry B, Lega B, Jobst B, Davis KA, Inman C, Sheth SA, Wanda PA, Ezzyat Y, Das SR, Stein J, Gorniak R, Jacobs J The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Apr
Widespread theta synchrony and high-frequency desynchronization underlies enhanced cognition.
Solomon EA, Kragel JE, Sperling MR, Sharan A, Worrell G, Kucewicz M, Inman CS, Lega B, Davis KA, Stein JM, Jobst BC, Zaghloul KA, Sheth SA, Rizzuto DS, Kahana MJ Nature communications 2017 Nov 8 1 1704
Seizures in glioma patients: An overview of incidence, etiology, and therapies.
Samudra N, Zacharias T, Plitt A, Lega B, Pan E, Journal of the neurological sciences 2019 Sep 404 80-85
Role of phospholipase A2 in the stimulation of sponge cell proliferation by homologous lectin.
Gramzow M, Schröder HC, Fritsche U, Kurelec B, Robitzki A, Zimmermann H, Friese K, Kreuter MH, Müller WE, Cell 1989 Dec 59 5 939-48
Cortico-cortical evoked potentials for sites of early versus late seizure spread in stereoelectroencephalography.
Lega B, Dionisio S, Flanigan P, Bingaman W, Najm I, Nair D, Gonzalez-Martinez J, Epilepsy research 2015 Sep 115 17-29
Interictal epileptiform discharges impair word recall in multiple brain areas.
Horak PC, Meisenhelter S, Song Y, Testorf ME, Kahana MJ, Viles WD, Bujarski KA, Connolly AC, Robbins AA, Sperling MR, Sharan AD, Worrell GA, Miller LR, Gross RE, Davis KA, Roberts DW, Lega B, Sheth SA, Zaghloul KA, Stein JM, Das SR, Rizzuto DS, Jobst BC Epilepsia 2016 Dec
Direct Electrical Stimulation of the Human Entorhinal Region and Hippocampus Impairs Memory.
Jacobs J, Miller J, Lee SA, Coffey T, Watrous AJ, Sperling MR, Sharan A, Worrell G, Berry B, Lega B, Jobst BC, Davis K, Gross RE, Sheth SA, Ezzyat Y, Das SR, Stein J, Gorniak R, Kahana MJ, Rizzuto DS Neuron 2016 Dec 92 5 983-990
Stereo-Encephalography Versus Subdural Electrodes for Seizure Localization.
Podkorytova I, Hoes K, Lega B, Neurosurgery clinics of North America 2016 Jan 27 1 97-109
Direct Brain Stimulation Modulates Encoding States and Memory Performance in Humans.
Ezzyat Y, Kragel JE, Burke JF, Levy DF, Lyalenko A, Wanda P, O'Sullivan L, Hurley KB, Busygin S, Pedisich I, Sperling MR, Worrell GA, Kucewicz MT, Davis KA, Lucas TH, Inman CS, Lega BC, Jobst BC, Sheth SA, Zaghloul K, Jutras MJ, Stein JM, Das SR, Gorniak R, Rizzuto DS, Kahana MJ Current biology : CB 2017 Apr
Modulation of Oscillatory Power and Connectivity in the Human Posterior Cingulate Cortex Supports the Encoding and Retrieval of Episodic Memories.
Lega B, Germi J, Rugg M, Journal of cognitive neuroscience 2017 Aug 29 8 1415-1432
- An essay concerning human understanding: how the cerebri anatome of Thomas Willis influenced John Locke.
- Restoring memory function after brain injury
- Memory encoding and retrieval