- Medical School - Case Western Reserve University School of Medicine (1975-1979)
- Fellowship - Parkland Health & Hospital System (1983-1986), Endocrinology & Metabolism
- Residency - Parkland Health & Hospital System (1980-1983), Internal Medicine
- Internship - Columbia Presbyterian Medical Center (1979-1980), Internal Medicine
Helen Hobbs, M.D.
-  Dallas Heart Ball Chair in Cardiology Research
- Philip O'Bryan Montgomery Jr., M.D., Distinguished Chair in Developmental Biology
- Eugene McDermott Distinguished Chair for the Study of Human Growth and Development
- Internal Medicine - Genetics
Helen H. Hobbs, M.D., is an Investigator of the Howard Hughes Medical Institute and a Professor of Internal Medicine and Molecular Genetics at the University of Texas Southwestern Medical Center. She obtained her undergraduate degree from Stanford University prior to attending Case Western Reserve University School of Medicine. After completing an internship in internal medicine at Columbia-Presbyterian Medical Center, she moved to Dallas, Texas where she finished her clinical training and served as chief resident in internal medicine at Parkland Memorial Hospital. She worked as a postdoctoral fellow in the laboratory of Drs. Michael Brown and Joseph Goldstein before joining the faculty of UT Southwestern in 1987. She is Director of the McDermott Center for Human Growth and Development, which serves as the Center for Human Genetics at UT Southwestern. She is also Director of the Dallas Heart Study, a longitudinal, multiethnic, population-based study of Dallas County. Her work focuses on defining the genetic determinants of plasma lipid levels and cardiovascular risk. Most recently, she has identified genetic variations that confer susceptibility to fatty liver disease.
- Arteriosclerosis, Thrombosis and Vascular Disease Council of the American Heart Association
- The Association of American Physicians
- American Society of Human Genetics
- American Society of Clinical Investigation
- Passano Award (with Jonathan Cohen) 2016
- Breakthrough Prize in Life Sciences 2015
- Pearl Meister Greengard Prize, Rockefeller University 2015
- Pasarow Foundation Award in Cardiovascular Research 2013
- International Atherosclerosis Society Prize 2012
- American Society of Clinical Investigation 1991
- The Association of American Physicians 1997
- Institute of Medicine 2004
- Heinrich Wieland Prize 2005
- American Academy of Arts and Sciences 2006
- National Academy of Sciences, 2007 2007
- American Heart Association Distinguished Scientist Award 2007
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.
Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, Boerwinkle E, Cohen JC, Hobbs HHNature genetics 2008 Dec 40 12 1461-5
Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease.
Jonathan C. Cohen, Ph.D., Eric Boerwinkle, Ph.D., Thomas H. Mosley, Jr., Ph.D., and Helen H. Hobbs, M.D.New England Journal of Medicine March 2006 354 1310-1312
Crystal structure of the human sterol transporter ABCG5/ABCG8
Lee J.-Y., Kinch L.N., Borek D.M., Wang J., Wang J., Urbatsch I.L., Xie X.-S., Grishin N.V., Cohen J.C., Otwinowski Z., Hobbs H.H., Rosenbaum D.M.Nature 2016 In Press
Relative Roles of ABCG5/ABCG8 in Liver and Intestine.
Wang J, Mitsche MA, Luetjohann D, Cohen JC, Xie XS, Hobbs HHJournal of lipid research 2014 Nov
Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease.
Kozlitina J, Smagris E, Stender S, Nordestgaard BG, Zhou HH, Tybjærg-Hansen A, Vogt TF, Hobbs HH, Cohen JCNature genetics 2014 Feb
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.
- Triglyceride trafficking and metabolism
- LDL Metabolism
- Genetics and Pathogenesis of fatty liver disease