The Charles Cameron Sprague Clinical Science Building houses clinical faculty in the departments of:
- Anesthesiology and Pain Management
- Internal Medicine
- Neurology and Neurological Surgery
- Physical Medicine and Rehabilitation
The facility is named for Charles C. Sprague, M.D., the first President of UT Southwestern Medical Center, who served from 1972 to 1986. It is connected to Parkland Memorial Hospital and Zale Lipshy Pavilion – William P. Clements Jr. University Hospital.