Research

Neuroscience is entering a new era of innovation in which fundamental discoveries can transform basic and translational research. Ultimately, these discoveries will expand the potential to treat and prevent brain, spine, nerve, and muscle disorders. The Peter O’Donnell Jr. Brain Institute is focused on establishing a new research paradigm built on scientific rigor, interdisciplinary collaboration, and open innovation to accelerate advances in science and technology. 

With teams of international scientific leaders, including some teams led by Nobel Laureates, UT Southwestern’s Peter O’Donnell Jr. Brain Institute continues to pave the way for new advances in brain research. This research includes transformative programs in neurodegeneration, neuromodulation, neurorepair, and neuro-oncology. By taking advantage of the latest imaging technologies, making profound breakthroughs related to the mechanisms of brain disease, and improving our ability to analyze massive amounts of data, we continue to make discoveries across all disciplines.

Our teams are involved in more than 500 studies across all departments and centers; examples include:

• The Department of Neuroscience focuses on neuronal and brain functions as they relate to health and diseases.
• The Hamon Center for Regenerative Science and Medicine aims to improve human health by applying discoveries of the fundamental mechanisms of tissue formation and repair to develop strategies and medicines that enhance tissue regeneration.
• The Center for Alzheimer’s and Neurodegenerative Diseases researches potential treatments to cure or halt the progression of dementia and related disorders.
• The Department of Psychiatry conducts research and provides patient care for a full range of psychiatric conditions.
• The Texas Institute for Brain Injury and Repair promotes research and education to enhance the treatment and diagnosis of brain injuries.
• The Annette G. Strauss Center for Neuro-Oncology focuses on improving treatments and researching tumors of the central nervous system.
• The Center for Translational Neurodegeneration Research focuses on the study of Apolipoprotein E receptors and their effect on the modulation of the hippocampus and the genetic mutations that are associated with Alzheimer’s disease.

See all departments and centers associated with the O'Donnell Brain Institute.