- Residency - Johns Hopkins School of Medicine (2002-2005), Neurology
- Internship - Rush-Presbyterian-St. Lukes Med Ctr - GME (2001-2002), Internal Medicine
- Medical School - Baylor College of Medicine (1997-2001)
Benjamin Greenberg, M.D.
Vice Chair of Clinical & Translational Research
- Cain Denius Scholar in Mobility Disorders
- Distinguished Teaching Professor
- Autoimmune Neurology
Benjamin M. Greenberg, M.D., M.H.S., is a Professor and the Cain Denius Scholar in Mobility Disorders in the Department of Neurology at UT Southwestern Medical Center. He also has an appointment in the Department of Pediatrics.
Dr. Greenberg is an internationally recognized expert in treating rare autoimmune disorders of the central nervous system.
He currently serves as the Vice Chair of Translational Research and Strategic Initiatives for the Department of Neurology. He is also the interim Director of the Multiple Sclerosis Center and the Director of the Neurosciences Clinical Research Center. In addition, he serves as Director of the Transverse Myelitis and Neuromyelitis Optica Program and the Pediatric Demyelinating Disease Program at Children’s Medical Center – which he established as one of only two U.S. programs of its kind.
Dr. Greenberg earned his medical degree at Baylor College of Medicine before completing an internal medicine internship at Chicago’s Rush Presbyterian-St. Luke’s Medical Center. He performed his neurology residency at the Johns Hopkins School of Medicine, serving as Chief Resident his final year.
He also holds an M.H.S. in molecular microbiology and immunology from the Bloomberg School of Public Health, as well as a bachelor’s degree in the history of medicine – both from Johns Hopkins.
Dr. Greenberg splits his clinical time between adult and pediatric patients, routinely consulting on the inpatient units of William P. Clements Jr. and Zale Lipshy University Hospitals, Parkland, and Children’s Medical Center.
His research focuses on better diagnosing, prognosticating, and treating demyelinating diseases and nervous system infections. He also coordinates clinical trials to evaluate new treatments to prevent neurologic damage and restore function to affected patients.
In addition, Dr. Greenberg has led an effort to improve biorepository development and create uniform protocols for sample handling and analysis. As part of this initiative, his collaborative research has identified novel biomarkers that could be key to distinguishing between patients with various neurologic disorders.
Prior to his recruitment to UT Southwestern in 2009, Dr. Greenberg was on the faculty of the Johns Hopkins Division of Neuroimmunology, serving as the Director of the Encephalitis Center and Co-director of the nation’s first dedicated Transverse Myelitis Center.
Certified by the American Board of Psychiatry and Neurology, Dr. Greenberg is a three-time Texas Monthly Rising Star and was included in D Magazine's Best Doctors list for 2016-2022. He was also named a Super Doctor by Texas Monthly in 2018.
Meet Dr. Greenberg
Autoimmune Disorders Expert in Dallas
Neurologist Dr. Benjamin Greenberg is an internationally recognized expert in treating adults and children with autoimmune disorders of the central nervous system. He specializes in treating patients with transverse myelitis (TM), neuromyelitis optica (NMO, or Devic’s disease), and multiple sclerosis (MS), as well as children with TM, MS, and other conditions such as autoimmune encephalitis and acute demyelinating encephalomyelitis (ADEM).
Because the diseases are rare, patients can have a hard time finding a medical “home” – a place where the clinicians specialize in treating and better understanding these complex, sometimes debilitating conditions. Dr. Greenberg and the team at UT Southwestern Medical Center offer that home, treating patients from around the world with these disorders.
“It’s been very rewarding to help create a team that has virtually no match in terms of the variety and depth of highly specialized skill sets we offer,” Dr. Greenberg says.
As an example, one common misconception people have about demyelinating diseases is that after an acute event, the recovery time is limited. Some nonspecialists tell patients with transverse myelitis that the function they will recover will be within six to 12 months of the event will be the limit of their recovery.
“Our work and experience has shown us that’s just not the case,” Dr. Greenberg says. “We see adults and children recover function years out from acute events. We often have to remind people that there’s not a time limit on their window for recovery.”
A three-time Texas Monthly Rising Star, Dr. Greenberg believes that UT Southwestern’s multidisciplinary, evidence-based approach is the key to delivering the best care available – both acute and long-term.
“We have a team of experts who are passionate about helping patients with these conditions, and taking an active presence on the national and international stage in understanding and defining treatment options.”
Education & Training
Professional Associations & Affiliations
- American Academy of Neurology
- Transverse Myelitis Association (2004), http://myelitis.org
- International Society for Biological and Environmental Repositories (2009)
Honors & Awards
- D Magazine Best Doctor 2016-2022
- University of Texas Southwestern Academy of Teachers 2016
- University of Texas Board of Regents Teaching Award 2015
- Neurosciences Teaching Award, 2013, 2014, 2015, 2016, 2017
- Fred Baskin Investigator Award 2011, Research Award
- Frank Ford 2008, Depart of Neurology Teaching Award
- Guy McKhann 2005, Resident Teaching Award
- Service Award From Maryland 2004, Multiple Sclerosis Society
- Intern of the Year Award 2002, Rush Internal Medicine
- 2009 Neurology Teaching Award
- Neurosciences Teaching Award, 2010, 2011, 2012
Books & Publications
Future research directions in multiple sclerosis therapies.
Greenberg BM, Calabresi PA Seminars in neurology 2008 Feb 28 1 121-7
Optical coherence tomography as a potential readout in clinical trials.
Greenberg BM, Frohman E Therapeutic advances in neurological disorders 2010 May 3 3 153-60
Epidemiology of neuromyelitis optica in the United States: a multicenter analysis.
Mealy MA, Wingerchuk DM, Greenberg BM, Levy M Archives of neurology 2012 Sep 69 9 1176-80
Effect of 4-aminopyridine on vision in multiple sclerosis patients with optic neuropathy.
Horton L, Conger A, Conger D, Remington G, Frohman T, Frohman E, Greenberg B Neurology 2013 Apr
Modulation of immune function occurs within hours of therapy initiation for multiple sclerosis.
Ayers CL, Mendoza JP, Sinha S, Cunnusamy K, Greenberg BM, Frohman EM, Karandikar NJ Clinical immunology (Orlando, Fla.) 2013 May 147 2 105-19
Proteoform analysis of lipocalin-type prostaglandin D-synthase from human cerebrospinal fluid by isoelectric focusing and superficially porous liquid chromatography with fourier transform mass spectrometry.
Zhang J, Corbett JR, Plymire DA, Greenberg BM, Patrie SM Proteomics 2014 Feb
Herpes Simplex Encephalitis as a Potential Cause of Anti-N-Methyl-d-Aspartate Receptor Antibody Encephalitis: Report of 2 Cases.
Desena A, Graves D, Warnack W, Greenberg BM JAMA neurology 2014 Jan
JC Virus in CD34+ and CD19+ Cells in Patients With Multiple Sclerosis Treated With Natalizumab.
Frohman EM, Monaco MC, Remington G, Ryschkewitsch C, Jensen PN, Johnson K, Perkins M, Liebner J, Greenberg B, Monson N, Frohman TC, Douek D, Major EO JAMA neurology 2014 Mar
Challenges and opportunities in designing clinical trials for neuromyelitis optica.
Weinshenker BG, Barron G, Behne JM, Bennett JL, Chin PS, Cree BA, de Seze J, Flor A, Fujihara K, Greenberg B, Higashi S, Holt W, Khan O, Knappertz V, Levy M, Melia AT, Palace J, Smith TJ, Sormani MP, Van Herle K, VanMeter S, Villoslada P, Walton MK, Wasiewski W, Wingerchuk DM, Yeaman MR Neurology 2015 Apr 84 17 1805-1815
MSPrecise: A molecular diagnostic test for multiple sclerosis using next generation sequencing.
Rounds WH, Salinas EA, Wilks TB, Levin MK, Ligocki AJ, Ionete C, Pardo CA, Vernino S, Greenberg BM, Bigwood DW, Eastman EM, Cowell LG, Monson NL Gene 2015 Jul
A Distinct Class of Antibodies May Be an Indicator of Gray Matter Autoimmunity in Early and Established Relapsing Remitting Multiple Sclerosis Patients.
Ligocki AJ, Rivas JR, Rounds WH, Guzman AA, Li M, Spadaro M, Lahey L, Chen D, Henson PM, Graves D, Greenberg BM, Frohman EM, Sally Ward E, Robinson W, Meinl E, White CL, Stowe AM, Monson NL ASN neuro 2015 Oct 7 5
Distinct effects of obesity and puberty on risk and age at onset of pediatric MS.
Chitnis T, Graves J, Weinstock-Guttman B, Belman A, Olsen C, Misra M, Aaen G, Benson L, Candee M, Gorman M, Greenberg B, Krupp L, Lotze T, Mar S, Ness J, Rose J, Rubin J, Schreiner T, Tillema J, Waldman A, Rodriguez M, Casper C, Waubant E Annals of clinical and translational neurology 2016 Dec 3 12 897-907
Diagnostic and therapeutic strategies for management of autoimmune encephalopathies.
Dubey D, Blackburn K, Greenberg B, Stuve O, Vernino S Expert review of neurotherapeutics 2016 May 1-13
Aquaporin-4 serostatus does not predict response to immunotherapy in neuromyelitis optica spectrum disorders.
Mealy MA, Kim SH, Schmidt F, López R, Jimenez Arango JA, Paul F, Wingerchuk DM, Greenberg BM, Kim HJ, Levy M Multiple sclerosis (Houndmills, Basingstoke, England) 2017 Aug 1352458517730131
High-dose methotrexate with leucovorin rescue: For monumentally severe CNS inflammatory syndromes.
Beh SC, Kildebeck E, Narayan R, Desena A, Schell D, Rowe ES, Rowe V, Burns D, Whitworth L, Frohman TC, Greenberg B, Frohman EM Journal of the neurological sciences 2017 Jan 372 187-195
A double-blind, placebo-controlled, single ascending-dose study of remyelinating antibody rHIgM22 in people with multiple sclerosis.
Eisen A, Greenberg BM, Bowen JD, Arnold DL, Caggiano AO Multiple sclerosis journal - experimental, translational and clinical 2017 Oct-Dec 3 4 2055217317743097
Myelin oligodendrocyte glycoprotein-specific antibodies from multiple sclerosis patients exacerbate disease in a humanized mouse model.
Khare P, Challa DK, Devanaboyina SC, Velmurugan R, Hughes S, Greenberg BM, Ober RJ, Ward ES Journal of autoimmunity 2017 Sep
Statistical classifiers for diagnosing disease from immune repertoires: a case study using multiple sclerosis.
Ostmeyer J, Christley S, Rounds WH, Toby I, Greenberg BM, Monson NL, Cowell LG BMC bioinformatics 2017 Sep 18 1 401
Progressive multifocal leukoencephalopathy after fingolimod treatment.
Berger JR, Cree BA, Greenberg B, Hemmer B, Ward BJ, Dong VM, Merschhemke M Neurology 2018 Apr
Safety and efficacy of plasma exchange in pediatric transverse myelitis.
Noland DK, Greenberg BM Neurology. Clinical practice 2018 Aug 8 4 327-330
New onset transverse myelitis diagnostic accuracy and patient experiences.
Greenberg BM, Krishnan C, Harder L Multiple sclerosis and related disorders 2019 Jan 30 42-44
Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis.
Greenberg BM, Casper TC, Mar SS, Ness JM, Plumb P, Liang S, Goyal M, Weinstock-Guttman B, Rodriguez M, Aaen GS, Belman A, Barcellos LF, Rose JW, Gorman MP, Benson LA, Candee M, Chitnis T, Harris YC, Kahn IL, Roalstad S, Hart J, Lotze TE, Rensel M, Rubin JP, Schreiner TL, Tillema JM, Waldman AT, Krupp L, Graves J, Drake K, Waubant E, Neurology(R) neuroimmunology & neuroinflammation 2021 09 8 5
Rituximab dosing and monitoring strategies in neuromyelitis optica patients: creating strategies for therapeutic success.
Greenberg BM, Graves D, Remington G, Hardeman P, Mann M, Karandikar N, Stuve O, Monson N, Frohman E Multiple sclerosis (Houndmills, Basingstoke, England) 2012 Jul 18 7 1022-6
CD40-Mediated NF-?B Activation in B Cells Is Increased in Multiple Sclerosis and Modulated by Therapeutics.
Chen D, Ireland SJ, Remington G, Alvarez E, Racke MK, Greenberg B, Frohman EM, Monson NL Journal of immunology (Baltimore, Md. : 1950) 2016 Oct
Human Aquaporin 4281-300 is the immunodominant linear determinant in the context of HLA-DRB1*03:01: relevance for diagnosing and monitoring patients with Neuromyelitis Optica.
Arellano B, Hussain R, Zacharias T, Yoon J, David C, Zein S, Steinman L, Forsthuber T, Greenberg BM, Lambracht-Washington D, Ritchie AM, Bennett JL, Stüve O Archives of neurology 2012 Sep 69 9 1125-31
Uhthoff's phenomena in MS-clinical features and pathophysiology.
Frohman TC, Davis SL, Beh S, Greenberg BM, Remington G, Frohman EM Nature reviews. Neurology 2013 Jun
Top-Down Mass Spectrometry on Tissue Extracts and Biofluids with Isoelectric Focusing and Superficially Porous Silica Liquid Chromatography.
Zhang J, Roth MJ, Chang AN, Plymire DA, Corbett JR, Greenberg BM, Patrie SM Analytical chemistry 2013 Sep
Area postrema syndrome: Frequency, criteria, and severity in AQP4-IgG-positive NMOSD.
Shosha E, Dubey D, Palace J, Nakashima I, Jacob A, Fujihara K, Takahashi T, Whittam D, Leite MI, Misu T, Yoshiki T, Messina S, Elsone L, Majed M, Flanagan E, Gadoth A, Huebert C, Sagen J, Greenberg BM, Levy M, Banerjee A, Weinshenker B, Pittock SJ Neurology 2018 Sep
Translational research in neurology and neuroscience 2010: multiple sclerosis.
Stüve O, Kieseier BC, Hemmer B, Hartung HP, Awad A, Frohman EM, Greenberg BM, Racke MK, Zamvil SS, Phillips JT, Gold R, Chan A, Zettl U, Milo R, Marder E, Khan O, Eagar TN Archives of neurology 2010 Nov 67 11 1307-15
Memory B cells from a subset of treatment-naive relapsing-remitting multiple sclerosis patients elicit CD4(+) T-cell proliferation and IFN-? production in response to myelin basic protein and myelin oligodendrocyte glycoprotein.
Harp CT, Ireland S, Davis LS, Remington G, Cassidy B, Cravens PD, Stuve O, Lovett-Racke AE, Eagar TN, Greenberg BM, Racke MK, Cowell LG, Karandikar NJ, Frohman EM, Monson NL European journal of immunology 2010 Oct 40 10 2942-56
Cognitive functioning in pediatric transverse myelitis.
Harder LL, Holland AA, Frohman E, Graves D, Greenberg BM Multiple sclerosis (Houndmills, Basingstoke, England) 2012 Nov
"Light Switch" Mental Status Changes and Irritable Insomnia are Two Particularly Salient Features of Anti-NMDA Receptor Antibody Encephalitis.
DeSena AD, Greenberg BM, Graves D Pediatric neurology 2014 Jul 51 1 151-3
Pediatric transverse myelitis.
Absoud M, Greenberg BM, Lim M, Lotze T, Thomas T, Deiva K Neurology 2016 Aug 87 9 Suppl 2 S46-52
Dietary salt intake and time to relapse in paediatric multiple sclerosis.
Nourbakhsh B, Graves J, Casper TC, Lulu S, Waldman A, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Ness J, Rubin J, Krupp L, Gorman M, Benson L, Rodriguez M, Chitnis T, Rose J, Barcellos L, Waubant E Journal of neurology, neurosurgery, and psychiatry 2016 Jun
Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients.
Rivas JR, Ireland SJ, Chkheidze R, Rounds WH, Lim J, Johnson J, Ramirez DM, Ligocki AJ, Chen D, Guzman AA, Woodhall M, Wilson PC, Meffre E, White C, Greenberg BM, Waters P, Cowell LG, Stowe AM, Monson NL Acta neuropathologica 2016 Oct
Assessment of renal deterioration and associated risk factors in patients with multiple sclerosis.
Shakir NA, Satyanarayan A, Eastman J, Greenberg BM, Lemack GE Urology 2018 Sep
Comparison of Relapse and Treatment Failure Rates Among Patients With Neuromyelitis Optica: Multicenter Study of Treatment Efficacy.
Mealy MA, Wingerchuk DM, Palace J, Greenberg BM, Levy M JAMA neurology 2014 Jan
A case-control study of dietary salt intake in pediatric-onset multiple sclerosis.
McDonald J, Graves J, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Lulu S, Ness J, Harris Y, Rubin J, Candee M, Krupp LB, Gorman M, Benson L, Rodriguez M, Chitnis T, Mar S, Barcellos LF, Laraia B, Rose J, Roalstad S, Simmons T, Casper TC, Waubant E Multiple sclerosis and related disorders 2016 Mar 6 87-92
Induction of regulatory T-cells from memory T-cells is perturbed during acute exacerbation of multiple sclerosis.
Mohiuddin IH, Pillai V, Baughman EJ, Greenberg BM, Frohman EM, Crawford MP, Sinha S, Karandikar NJ Clinical immunology (Orlando, Fla.) 2016 May
Evaluating the association of allergies with multiple sclerosis susceptibility risk and disease activity in a pediatric population.
Bourne T, Waltz M, Casper TC, Kavak K, Aaen G, Belman A, Benson L, Candee M, Chitnis T, Graves J, Greenberg B, Gorman M, Harris Y, Krupp L, Lotze T, Mar S, Ness J, Olsen C, Roalstad S, Rodriguez M, Rose J, Rubin J, Schreiner T, Tillema JM, Kahn I, Waldman A, Barcellos L, Waubant E, Weinstock-Guttman B Journal of the neurological sciences 2017 Apr 375 371-375
Several household chemical exposures are associated with pediatric-onset multiple sclerosis.
Mar S, Liang S, Waltz M, Casper TC, Goyal M, Greenberg B, Weinstock-Guttman B, Rodriguez M, Aaen G, Belman A, Barcellos LF, Rose J, Gorman M, Benson L, Candee M, Chitnis T, Harris Y, Kahn I, Roalsted S, Hart J, Lotze T, Moodley M, Ness J, Rensel M, Rubin J, Schreiner T, Tillema JM, Waldman A, Krupp L, Graves JS, Waubant E Annals of clinical and translational neurology 2018 Dec 5 12 1513-1521
Early infectious exposures are not associated with increased risk of pediatric-onset multiple sclerosis.
Suleiman L, Waubant E, Aaen G, Belman A, Benson L, Candee M, Chitnis T, Gorman M, Goyal M, Greenberg B, Harris Y, Hart J, Kahn I, Krupp L, Lotze T, Mar S, Moodley M, Ness J, Nourbakhsh B, Rensel M, Rodriguez M, Rose J, Rubin J, Schreiner T, Tillema JM, Waldman A, Weinstock-Guttman B, Casper TC, Waltz M, Graves JS Multiple sclerosis and related disorders 2018 Mar 22 103-107
Vitamin D genes influence MS relapses in children.
Graves JS, Barcellos LF, Krupp L, Belman A, Shao X, Quach H, Hart J, Chitnis T, Weinstock-Guttman B, Aaen G, Benson L, Gorman M, Greenberg B, Lotze T, Soe M, Ness J, Rodriguez M, Rose J, Schreiner T, Tillema JM, Waldman A, Casper TC, Waubant E, Multiple sclerosis (Houndmills, Basingstoke, England) 2019 May 1352458519845842
Anti-Myelin Oligodendrocyte Glycoprotein Antibody Associated With Gray Matter Predominant Transverse Myelitis Mimicking Acute Flaccid Myelitis: A Presentation of Two Cases.
Wang C, Narayan R, Greenberg B Pediatric neurology 2018 Jul
Pearls: multiple sclerosis.
Frohman EM, Greenberg BM Seminars in neurology 2010 Feb 30 1 97-101
Neuroantigen-specific CD8+ regulatory T-cell function is deficient during acute exacerbation of multiple sclerosis.
Baughman EJ, Mendoza JP, Ortega SB, Ayers CL, Greenberg BM, Frohman EM, Karandikar NJ Journal of autoimmunity 2011 Mar 36 2 115-24
Antibody-independent B cell effector functions in relapsing remitting multiple sclerosis: clues to increased inflammatory and reduced regulatory B cell capacity.
Ireland SJ, Blazek M, Harp CT, Greenberg B, Frohman EM, Davis LS, Monson NL Autoimmunity 2012 Aug 45 5 400-14
Objective characterization of the relative afferent pupillary defect in MS.
Blazek P, Davis SL, Greenberg BM, Conger A, Conger D, Vernino S, Beh S, Stuve O, Saidha S, Ratchford JN, Green A, Calabresi PA, Balcer LJ, Frohman TC, Frohman EM Journal of the neurological sciences 2012 Dec 323 1-2 193-200
Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography.
Bennett J, de Seze J, Lana-Peixoto M, Palace J, Waldman A, Schippling S, Tenembaum S, Banwell B, Greenberg B, Levy M, Fujihara K, Chan K, Kim H, Asgari N, Sato D, Saiz A, Wuerfel J, Zimmermann H, Green A, Villoslada P, Paul F Multiple sclerosis (Houndmills, Basingstoke, England) 2015 Feb
Neuropsychological outcomes of pediatric demyelinating diseases: a review.
Tan A, Hague C, Greenberg BM, Harder L Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence 2017 Jun 1-23
Dietary factors and pediatric multiple sclerosis: A case-control study.
Pakpoor J, Seminatore B, Graves JS, Schreiner T, Waldman AT, Lotze TE, Belman A, Greenberg BM, Weinstock-Guttman B, Aaen G, Tillema JM, McDonald JC, Hart J, Ness JM, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Chitnis T, Mar S, Kahn I, Rose J, Carmichael SL, Roalstad S, Waltz M, Casper TC, Waubant E Multiple sclerosis (Houndmills, Basingstoke, England) 2017 Jun 1352458517713343
Genetic risk factors for pediatric-onset multiple sclerosis.
Gianfrancesco MA, Stridh P, Shao X, Rhead B, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Schaefer C, Barcellos LF, Waubant E Multiple sclerosis (Houndmills, Basingstoke, England) 2017 Oct 1352458517733551
Atypical Anti-MOG syndrome with aseptic meningoencephalitis and pseudotumor cerebri-like presentations.
Narayan RN, Wang C, Sguigna P, Husari K, Greenberg B Multiple sclerosis and related disorders 2018 Oct 27 30-33
miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS.
Rhead B, Shao X, Graves JS, Chitnis T, Waldman AT, Lotze T, Schreiner T, Belman A, Krupp L, Greenberg BM, Weinstock-Guttman B, Aaen G, Tillema JM, Rodriguez M, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee MS, Gorman M, Benson L, Mar S, Kahn I, Rose J, Casper TC, Quach H, Quach D, Schaefer C, Waubant E, Barcellos LF, Annals of clinical and translational neurology 2019 Jun 6 6 1053-1061
Utilization of Visual Acuity Retroilluminated Charts for the Assessment of Afferent Visual System Dysfunction in a Pediatric Neuroimmunology Population.
Sguigna PV, McCreary MC, Conger DL, Graves JS, Benson LA, Waldman AT, Greenberg BM, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2020 Aug
Molecular Level Characterization of Circulating Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum Disorder.
Li J, Bazzi SA, Schmitz F, Tanno H, McDaniel JR, Lee CH, Joshi C, Kim JE, Monson N, Greenberg BM, Hedfalk K, Melamed E, Ippolito GC, Neurology(R) neuroimmunology & neuroinflammation 2021 Jul 8 5
Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells.
Cunnusamy K, Baughman EJ, Franco J, Ortega SB, Sinha S, Chaudhary P, Greenberg BM, Frohman EM, Karandikar NJ Clinical immunology (Orlando, Fla.) 2014 May-Jun 152 1-2 115-26
Greenberg BM, Frohman EM Continuum (Minneapolis, Minn.) 2015 Feb 21 1 Spinal Cord Disorders 121-31
Neuroimmune disorders of the central nervous system in children in the molecular era.
Wells E, Hacohen Y, Waldman A, Tillema JM, Soldatos A, Ances B, Benseler S, Bielekova B, Dale RC, Dalmau J, Gaillard W, Gorman M, Greenberg B, Hyslop A, Pardo CA, Tasker RC, Yeh EA, Bar-Or A, Pittock S, Vanderver A, Banwell B Nature reviews. Neurology 2018 Jun
Urodynamics findings in transverse myelitis patients with lower urinary tract symptoms: Results from a tertiary referral urodynamic center.
Gliga LA, Lavelle RS, Christie AL, Coskun B, Greenberg BM, Carmel ME, Lemack GE Neurourology and urodynamics 2015 Nov
Low serum vitamin D levels and recurrent inflammatory spinal cord disease.
Mealy MA, Newsome S, Greenberg BM, Wingerchuk D, Calabresi P, Levy M Archives of neurology 2012 Mar 69 3 352-6
Updated diagnostic criteria for neuromyelitis optica spectrum disorder: Similar outcomes of previously separate cohorts.
McCreary M, Mealy MA, Wingerchuk DM, Levy M, DeSena A, Greenberg BM Multiple sclerosis journal - experimental, translational and clinical 2018 Oct-Dec 4 4 2055217318815925
Selective Depletion of Antigen-Specific Antibodies for the Treatment of Demyelinating Disease.
Sun W, Khare P, Wang X, Challa DK, Greenberg BM, Ober RJ, Ward ES, Molecular therapy : the journal of the American Society of Gene Therapy 2020 Nov
A Callosal Catastrophe: Toxic Leukoencephalopathy Associated with Thermogenic Weight Loss Supplement Use.
Mahdavi ZK, Narayan R, Mainali S, Greenberg BM, Aiyagari V, McDonagh DL Neurocritical care 2017 Oct
Requirement for safety monitoring for approved MS therapies - An overview.
Rommer PS, Zettl UK, Kieseier B, Hartung HP, Menge T, Frohman E, Greenberg BM, Hemmer B, Stüve O Clinical and experimental immunology 2013 Sep
Update on biomarkers in neuromyelitis optica.
Melamed E, Levy M, Waters PJ, Sato DK, Bennett JL, John GR, Hooper DC, Saiz A, Bar-Or A, Kim HJ, Pandit L, Leite MI, Asgari N, Kissani N, Hintzen R, Marignier R, Jarius S, Marcelletti J, Smith TJ, Yeaman MR, Han MH, Aktas O, Apiwattanakul M, Banwell B, Bichuetti D, Broadley S, Cabre P, Chitnis T, De Seze J, Fujihara K, Greenberg B, Hellwig K, Iorio R, Jarius S, Klawiter E, Kleiter I, Lana-Peixoto M, Nakashima null, O'Connor K, Palace J, Paul F, Prayoonwiwat N, Ruprecht K, Stuve O, Tedder T, Tenembaum S, Garrahan JP, Aires B, van Herle K, van Pelt D, Villoslada P, Waubant E, Weinshenker B, Wingerchuk D, Würfel J, Zamvil S Neurology® neuroimmunology & neuroinflammation 2015 Aug 2 4 e134
Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS.
Gianfrancesco MA, Stridh P, Rhead B, Shao X, Xu E, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Bäärnhielm M, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Metayer C, Schaefer C, Barcellos LF, Waubant E Neurology 2017 Mar
BRAF mutation leading to central nervous system Rosai-Dorfman disease.
Richardson TE, Wachsmann M, Oliver D, Abedin Z, Ye D, Burns DK, Raisanen JM, Greenberg BM, Hatanpaa KJ Annals of neurology 2018 Jul
Acute flaccid myelitis: long-term outcomes recorded in the CAPTURE study compared with paediatric transverse myelitis.
Greenberg B, Plumb P, Cutter G, Dean J, Desena A, Hopkins S, Krishnan C, Pardo C, Recio A, Schreiner T, Yeh EA, McCreary M, BMJ neurology open 2021 3 1 e000127
Infectious complications of temporary spinal catheter insertion for diagnosis of adult hydrocephalus and idiopathic intracranial hypertension.
Greenberg BM, Williams MA Neurosurgery 2008 Feb 62 2 431-5; discussion 435-6
Current and emerging multiple sclerosis therapeutics.
Greenberg BM, Khatri BO, Kramer JF Continuum (Minneapolis, Minn.) 2010 Oct 16 5 Multiple Sclerosis 58-77
No cerebral or cervical venous insufficiency in US veterans with multiple sclerosis.
Marder E, Gupta P, Greenberg BM, Frohman EM, Awad AM, Bagert B, Stüve O Archives of neurology 2011 Dec 68 12 1521-5
Transverse Myelitis Plus Syndrome and Acute Disseminated Encephalomyelitis Plus Syndrome: A Case Series of 5 Children.
Desena A, Graves D, Morriss MC, Greenberg BM JAMA neurology 2014 Mar
Unique characteristics of optical coherence tomography (OCT) results and visual acuity testing in myelin oligodendrocyte glycoprotein (MOG) antibody positive pediatric patients.
Narayan RN, McCreary M, Conger D, Wang C, Greenberg BM Multiple sclerosis and related disorders 2018 Dec 28 86-90
Vitamin D status and effect of low-dose cholecalciferol and high-dose ergocalciferol supplementation in multiple sclerosis.
Hiremath GS, Cettomai D, Baynes M, Ratchford JN, Newsome S, Harrison D, Kerr D, Greenberg BM, Calabresi PA Multiple sclerosis (Houndmills, Basingstoke, England) 2009 Jun 15 6 735-40
Peripheral nerve involvement in adult and pediatric patients with central nervous system inflammatory disease-reply.
Greenberg BM JAMA neurology 2015 Jan 72 1 123-4
Optic neuritis: A mechanistic view.
Burton EV, Greenberg BM, Frohman EM Pathophysiology : the official journal of the International Society for Pathophysiology / ISP 2011 Feb 18 1 81-92
The antibody genetics of multiple sclerosis: comparing next-generation sequencing to sanger sequencing.
Rounds WH, Ligocki AJ, Levin MK, Greenberg BM, Bigwood DW, Eastman EM, Cowell LG, Monson NL Frontiers in neurology 2014 5 166
Intravenous methylprednisolone versus therapeutic plasma exchange for treatment of anti-n-methyl-d-aspartate receptor antibody encephalitis: A retrospective review.
DeSena AD, Noland DK, Matevosyan K, King K, Phillips L, Qureshi SS, Greenberg BM, Graves D Journal of clinical apheresis 2015 Feb
Acute flaccid myelitis: cause, diagnosis, and management.
Murphy OC, Messacar K, Benson L, Bove R, Carpenter JL, Crawford T, Dean J, DeBiasi R, Desai J, Elrick MJ, Farias-Moeller R, Gombolay GY, Greenberg B, Harmelink M, Hong S, Hopkins SE, Oleszek J, Otten C, Sadowsky CL, Schreiner TL, Thakur KT, Van Haren K, Carballo CM, Chong PF, Fall A, Gowda VK, Helfferich J, Kira R, Lim M, Lopez EL, Wells EM, Yeh EA, Pardo CA, Lancet (London, England) 2020 Dec
Increased Prevalence of Familial Autoimmune Disease in Children With Opsoclonus-Myoclonus Syndrome.
Santoro JD, Kerr LM, Codden R, Casper TC, Greenberg BM, Waubant E, Kong SW, Mandl KD, Gorman MP, Neurology(R) neuroimmunology & neuroinflammation 2021 Nov 8 6
Treatment of acute transverse myelitis and its early complications.
Greenberg BM Continuum (Minneapolis, Minn.) 2011 Aug 17 4 733-43
High Dose Cyclophosphamide Reduces Disease Activity in Aggressive Multiple Sclerosis
Krishnan C., Kaplin A., Brodsky R., Drachman D., Jones, R., Pham D., Richert N., Pardo C., Yousem D., Candelario A., Allie R., Hammond E., Quigg M., Trecker C., McArthur J., Johnson R., Nath A., Greenberg B., Calabresi P., Kerr D Archives of Neurology August 2008 65(8) 1044-51
Examining the contributions of environmental quality to pediatric multiple sclerosis.
Lavery AM, Waldman AT, Charles Casper T, Roalstad S, Candee M, Rose J, Belman A, Weinstock-Guttman B, Aaen G, Tillema JM, Rodriguez M, Ness J, Harris Y, Graves J, Krupp L, Benson L, Gorman M, Moodley M, Rensel M, Goyal M, Mar S, Chitnis T, Schreiner T, Lotze T, Greenberg B, Kahn I, Rubin J, Waubant E Multiple sclerosis and related disorders 2017 Nov 18 164-169
Idiopathic transverse myelitis: corticosteroids, plasma exchange, or cyclophosphamide.
Greenberg BM, Thomas KP, Krishnan C, Kaplin AI, Calabresi PA, Kerr DA Neurology 2007 May 68 19 1614-7
International consensus diagnostic criteria for neuromyelitis optica spectrum disorders.
Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG Neurology 2015 Jun
The spectrum of autoimmune encephalopathies.
Dubey D, Sawhney A, Greenberg B, Lowden A, Warnack W, Khemani P, Stuve O, Vernino S Journal of neuroimmunology 2015 Oct 287 93-7
Persistence of parenchymal and perivascular T-cells in treatment-refractory anti-N-methyl-D-aspartate receptor encephalitis.
Filatenkov A, Richardson TE, Daoud E, Johnson-Welch SF, Ramirez DM, Torrealba J, Greenberg B, Monson NL, Rajaram V Neuroreport 2017 Sep 28 14 890-895
Direct and consensual murine pupillary reflex metrics: establishing normative values.
Hussain RZ, Hopkins SC, Frohman EM, Eagar TN, Cravens PC, Greenberg BM, Vernino S, Stüve O Autonomic neuroscience : basic & clinical 2009 Dec 151 2 164-7
Expansion of CD27(high) plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation.
Ligocki AJ, Rounds WH, Cameron EM, Harp CT, Frohman EM, Courtney AM, Vernino S, Cowell LG, Greenberg B, Monson NL Genes and immunity 2013 Apr
Clinical Approach to Pediatric Transverse Myelitis, Neuromyelitis Optica Spectrum Disorder and Acute Flaccid Myelitis.
Wang C, Greenberg B, Children (Basel, Switzerland) 2019 May 6 5
Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis.
Chitnis T, Arnold DL, Banwell B, Brück W, Ghezzi A, Giovannoni G, Greenberg B, Krupp L, Rostásy K, Tardieu M, Waubant E, Wolinsky JS, Bar-Or A, Stites T, Chen Y, Putzki N, Merschhemke M, Gärtner J The New England journal of medicine 2018 09 379 11 1017-1027
A randomized, blinded, parallel-group, pilot trial of mycophenolate mofetil (CellCept) compared with interferon beta-1a (Avonex) in patients with relapsing-remitting multiple sclerosis.
Frohman EM, Cutter G, Remington G, Gao H, Rossman H, Weinstock-Guttman B, Durfee JE, Conger A, Carl E, Treadaway K, Lindzen E, Salter A, Frohman TC, Shah A, Bates A, Cox JL, Dwyer MG, Stüve O, Greenberg BM, Racke MK, Zivadinov R Therapeutic advances in neurological disorders 2010 Jan 3 1 15-28
Carotid cavernous fistula imitating brainstem glioma.
Clark SW, Dang T, Toth G, Pride GL, Greenberg B, Warnack W Archives of neurology 2011 Feb 68 2 256-7
Multifocal visual evoked potentials are influenced by variable contrast stimulation in MS.
Frohman AR, Schnurman Z, Conger A, Conger D, Beh S, Greenberg B, Sutter E, Calabresi PA, Balcer LJ, Frohman TC, Frohman EM Neurology 2012 Aug 79 8 797-801
Monocular and binocular low-contrast visual acuity and optical coherence tomography in pediatric multiple sclerosis.
Waldman AT, Hiremath G, Avery RA, Conger A, Pineles SL, Loguidice MJ, Talman LS, Galetta KM, Shumski MJ, Wilson J, Ford E, Lavery AM, Conger D, Greenberg BM, Ellenberg JH, Frohman EM, Balcer LJ, Calabresi PA Multiple sclerosis and related disorders 2013 May 3 3 326-334
Blind and Confused.
Sharma VD, Malafronte P, De Simone N, Greenberg BM JAMA neurology 2013 May 1-5
Neuromyelitis Optica Spectrum Disorder Associated With Autoimmune Hemolytic Anemia and Lymphoma.
Wang Y, Miocinovic S, Greenberg BM The neurologist 2015 Aug 20 2 33-4
Trial of Satralizumab in Neuromyelitis Optica Spectrum Disorder.
Yamamura T, Kleiter I, Fujihara K, Palace J, Greenberg B, Zakrzewska-Pniewska B, Patti F, Tsai CP, Saiz A, Yamazaki H, Kawata Y, Wright P, De Seze J, The New England journal of medicine 2019 Nov 381 22 2114-2124
Research Directions in Multiple Sclerosis Therapy
Greenberg B., Calabresi P Seminars in Neurology February 2008 28(1) 121-127
Central nervous system infections in the intensive care unit.
Greenberg BM Seminars in neurology 2008 Nov 28 5 682-9
Elevated CNS inflammation in patients with preclinical Alzheimer's disease.
Monson NL, Ireland SJ, Ligocki AJ, Chen D, Rounds WH, Li M, Huebinger RM, Munro Cullum C, Greenberg BM, Stowe AM, Zhang R Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2013 Oct
What is causing this patient's headache and seizures?
Hardeman P, Greenberg B JAAPA : official journal of the American Academy of Physician Assistants 2018 Feb 31 2 56-57
The princess and the p-value: A case report of suspected autoimmune encephalitis and functional neurological disorder in a pediatric patient.
Wilkinson-Smith A, Greenberg B, Keech A Applied neuropsychology. Child 2018 Sep 1-8
Author response: Progressive multifocal leukoencephalopathy after fingolimod treatment.
Berger JR, Cree BA, Greenberg B, Hemmer B, Ward BJ, Dong VM, Merschhemke M Neurology 2019 Jan 92 3 151
Acute Disseminated Encephalomyelitis (ADEM) and Increased Intracranial Pressure Associated With Anti-Myelin Oligodendrocyte Glycoprotein Antibodies.
Narayan RN, Wang C, Greenberg BM, Pediatric neurology 2019 Mar
Two cases of aquaporin-4 positive neuromyelitis optica associated with T-cell lymphoma.
Blackburn K, Wang C, Greenberg B, Journal of neuroimmunology 2019 Oct 338 577092
Natalizumab and progressive multifocal leukoencephalopathy: what are the causal factors and can it be avoided?
Warnke C, Menge T, Hartung HP, Racke MK, Cravens PD, Bennett JL, Frohman EM, Greenberg BM, Zamvil SS, Gold R, Hemmer B, Kieseier BC, Stüve O Archives of neurology 2010 Aug 67 8 923-30
A surprisingly low prevalence of demonstrable stress urinary incontinence and pelvic organ prolapse in women with multiple sclerosis followed at a tertiary neurogenic bladder clinic.
Dillon BE, Seideman CA, Lee D, Greenberg B, Frohman EM, Lemack GE The Journal of urology 2013 Mar 189 3 976-9
Vitamin D During Pregnancy and Multiple Sclerosis: An Evolving Association.
Greenberg BM JAMA neurology 2016 Mar
Idiopathic Transverse Myelitis: Corticosteroids, Plasma Exchange, or Cyclophosphamide.
Greenberg B, Thomas K, Krishnan C, Kaplin A, Calabresi P, Kerr D Neurology May 2007 68(19) 1614-1617
Associations between retinal nerve fiber layer abnormalities and optic nerve examination.
Cettomai D, Hiremath G, Ratchford J, Venkatesan A, Greenberg BM, McGready J, Pardo CA, Kerr DA, Frohman E, Balcer LJ, McArthur JC, Calabresi PA Neurology 2010 Oct 75 15 1318-25
Symptomatic therapy in multiple sclerosis.
Frohman TC, Castro W, Shah A, Courtney A, Ortstadt J, Davis SL, Logan D, Abraham T, Abraham J, Remington G, Treadaway K, Graves D, Hart J, Stuve O, Lemack G, Greenberg B, Frohman EM Therapeutic advances in neurological disorders 2011 Mar 4 2 83-98
Beh SC, Greenberg BM, Frohman T, Frohman EM Neurologic clinics 2013 Feb 31 1 79-138
Anticipated benefits and surprising effects of daclizumab in multiple sclerosis.
Stüve O, Greenberg BM Lancet neurology 2010 Apr 9 4 337-8
Current and emerging therapies in multiple sclerosis: a systematic review.
Castro-Borrero W, Graves D, Frohman TC, Flores AB, Hardeman P, Logan D, Orchard M, Greenberg B, Frohman EM Therapeutic advances in neurological disorders 2012 Jul 5 4 205-20
Analysis of 30 Spinal Angiograms Falsely Reported as Normal in 18 Patients with Subsequently Documented Spinal Vascular Malformations.
Barreras P, Heck D, Greenberg B, Wolinsky JP, Pardo CA, Gailloud P AJNR. American journal of neuroradiology 2017 Jul
Author Correction: Neuroimmune disorders of the central nervous system in children in the molecular era.
Wells E, Hacohen Y, Waldman A, Tillema JM, Soldatos A, Ances B, Benseler S, Bielekova B, Dale RC, Dalmau J, Gaillard W, Gorman M, Greenberg B, Hyslop A, Pardo CA, Tasker RC, Yeh EA, Bar-Or A, Pittock S, Vanderver A, Banwell B Nature reviews. Neurology 2018 Dec 14 12 749
Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: a pilot study.
Frohman EM, Dwyer MG, Frohman T, Cox JL, Salter A, Greenberg BM, Hussein S, Conger A, Calabresi P, Balcer LJ, Zivadinov R Journal of the neurological sciences 2009 Jul 282 1-2 96-105
Fatigue, emotional functioning, and executive dysfunction in pediatric multiple sclerosis.
Holland AA, Graves D, Greenberg BM, Harder LL Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence 2012 Dec
Placebo studies should not be undertaken in NMO - No.
Greenberg BM Multiple sclerosis (Houndmills, Basingstoke, England) 2015 Apr
Does Autoimmunity have a Role in Myoclonic Astatic Epilepsy? A Case Report of Voltage Gated Potassium Channel Mediated Seizures.
Sirsi D, Dolce A, Greenberg BM, Thodeson D Annals of clinical case reports 2016 1
Pediatric Multiple Sclerosis: From Recognition to Practical Clinical Management.
Wang CX, Greenberg BM Neurologic clinics 2018 Feb 36 1 135-149
In Depth Evaluation of a Case of Presumed Myocarditis Following the Second Dose of COVID-19 mRNA Vaccine.
Muthukumar A, Narasimhan M, Li QZ, Mahimainathan L, Hitto I, Fuda F, Batra K, Jiang X, Zhu C, Schoggins J, Cutrell JB, Croft CL, Khera A, Drazner MH, Grodin JL, Greenberg BM, Mammen PPA, Morrison SJ, de Lemos JA, Circulation 2021 Jun
A blood-based gene expression assay that can identify patients with multiple sclerosis
Greenberg, B., Bigwood, B., Eastman, E. Journal of Neurology June 2008 255(S2) 79
Predicting the Outcome of Shunt Surgery in Normal Pressure Hydrocephalus.
Greenberg BM, Williams M Neurosurgery 2010 Jun 66 6 E1217
Interferon Beta and Long-term Disability in Multiple Sclerosis-Reply.
Greenberg BM, Frohman E JAMA neurology 2013 May 70 5 651-3
Reduction of disease activity and disability with high-dose cyclophosphamide in patients with aggressive multiple sclerosis.
Krishnan C, Kaplin AI, Brodsky RA, Drachman DB, Jones RJ, Pham DL, Richert ND, Pardo CA, Yousem DM, Hammond E, Quigg M, Trecker C, McArthur JC, Nath A, Greenberg BM, Calabresi PA, Kerr DA Archives of neurology 2008 Aug 65 8 1044-51
What is the true clinicopathologic spectrum of neuromyelitis optica?-Reply.
Greenberg BM, Wingerchuk D, Mealy M, Levy M JAMA neurology 2013 Feb 70 2 272-3
Interferon beta use and disability prevention in relapsing-remitting multiple sclerosis.
Greenberg BM, Balcer L, Calabresi PA, Cree B, Cross A, Frohman T, Gold R, Havrdova E, Hemmer B, Kieseier BC, Lisak R, Miller A, Racke MK, Steinman L, Stuve O, Wiendl H, Frohman E JAMA neurology 2013 Feb 70 2 248-51
Neurotherapeutic Strategies for Multiple Sclerosis.
Frohman TC, Beh SC, Kildebeck EJ, Narayan R, Treadaway K, Greenberg B, Frohman EM Neurologic clinics 2016 Aug 34 3 483-523
- Future research directions in multiple sclerosis therapies.
- Transverse Myelitis
- Neuromyelitis Optica
- Multiple Sclerosis
- Clinical Treatment Trials
- Biomarkers of Disease
- Autoimmune Neurology
Q&A by Dr. Greenberg
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December 1, 2016
Dr. Benjamin Greenberg on Transverse Myelitis
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Neurology Clinic - Multiple Sclerosis and Neuroimmunologyat James W. Aston Ambulatory Care Center 5303 Harry Hines Blvd., 8th Floor
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