- Fellowship - Harvard Medical School (1996-1999), Cardiology
- Chief Resident - UT Southwestern Medical Center (1995-1996), Internal Medicine
- Residency - UT Southwestern Medical Center (1993-1995), Internal Medicine
- Internship - UT Southwestern Medical Center (1992-1993), Internal Medicine
- Medical School - Harvard Medical School
James de Lemos, M.D.
- Sweetheart Ball - Kern Wildenthal, M.D., Ph.D., Distinguished Chair in Cardiology
- Internal Medicine - Cardiology
- General Cardiology
James de Lemos, M.D., is a Professor of Internal Medicine in the Division of Cardiology at UT Southwestern Medical Center. He is also Associate Director of UT Southwestern’s Cardiovascular Fellowship Program.
Dr. de Lemos graduated from Harvard Medical School and completed an internal medicine residency at UT Southwestern, where he also served as Chief Medical Resident. He completed a fellowship in cardiovascular medicine and served on the faculty at Harvard’s Brigham and Women’s Hospital in Boston before returning to UT Southwestern to join the faculty.
He has served on multiple committees of the American Heart Association and American College of Cardiology and is on the editorial board of Circulation, the Journal of the American College of Cardiology, the American Journal of Cardiology, and the American Heart Journal. He has mentored more than 25 post-doctoral research trainees and has authored or coauthored more than 300 manuscripts or book chapters.
He has won several teaching awards and consistently appears on the D Magazine “Best Doctors” and Texas Monthly “Super Doctors” lists.
Dr. de Lemos is active in clinical research, focusing on large-scale human studies and clinical trials. He was the lead author of the Z phase of the A-to-Z Trial, an international trial investigating different cholesterol-lowering strategies in patients with acute coronary syndromes. He is currently Medical Director of the Dallas Heart Study, a multiethnic population-based study of more than 6,000 adults from Dallas County. He also serves as the Research and Publications Director for the NCDR-ACTION Registry, the nation’s premier quality improvement initiative for patients with heart attacks.
Dr. de Lemos is married with three children and is an avid sports fan.
Meet Dr. de Lemos
Heart Specialist in Dallas
As Associate Director of the Cardiovascular Fellowship Program at UT Southwestern Medical Center, cardiologist James de Lemos, M.D., stays at the forefront of prevention and treatment of heart disease.
It’s the impact that he can make on patients’ lives, however, that he finds most rewarding. “Heart care is one area of medicine that we can offer patients a lot in terms of therapies that improve and lengthen their lives,” he says.
Dr. de Lemos treats the spectrum of cardiac disease, including coronary artery disease, atrial fibrillation and other arrhythmias, heart failure, and valve disease. He also sees patients hospitalized with advanced heart disease.
Additionally, he is active in several clinical research projects. Most notably, he’s the Medical Director for the Dallas Heart Study, a one-of-a-kind population-based study aiming, among other goals, to identify new genetic, protein, and imaging biomarkers that can detect cardiovascular disease at its earliest stages, when prevention is most effective.
“My research directly relates to my clinical practice, so I’m up-to-date on the latest advances in general cardiology care and prevention. I discuss my findings with my patients so they’re aware of what’s available and what’s coming,” he says.
When with patients, Dr. de Lemos takes time to understand their issues and provide an individualized approach to care – something all cardiologists at UT Southwestern aim to offer.
“We get to know our patients, their needs and specific goals with regard to their heart care, so we can make decisions based on their needs,” he says.
Dr. de Lemos looks forward to the next phase in care – gaining more insight into a patient’s risk for heart disease – to prevent it or keep it from getting worse. UT Southwestern researchers have helped develop some low-cost tests that are taking heart care in that direction.
“It’s an exciting time to be in heart care,” Dr. de Lemos says.
- American College of Cardiology (1996), Fellow
- American Heart Association (1998), Fellow
- Chair, Research and Publications Committee (2010), ACTION Registiry-GWTG
- AHA/ACC ST Elevation MI Guideline Committee (2010-2012)
- Society of Chest Pain Physicians (2011), Board of Trustees
- Elite Reviewer 2006, Journal of the American College of Cardiology
- Soma Weiss Award 1997, Excellence in Teaching, Brigham and Women’s Hospital
- Eugene Braunwald Fellowship 1999, Excellence in Clinical Research, Brigham and Women’s Hospital
- Internal Medicine Teaching Award 2005, Excellence in Teaching
- Sweetheart Ball-Kern Wildenthal MD, PhD Distinguished Chair 2009, Distinguished Chair in Cardiology
- Super Doctors, Cardiology 2010, Texas Monthly
- Core Clerkship Teaching Award 2011, UT Southwestern
- Best Doctors in Dallas, Cardiology 2005, D Magazine
- Association of University Cardiologists 2011
- Simon Dack Award for Medical Publications 2012, Journal of the American College of Cardiology
ST Elevation Myocardial infarction in Irwin and Rippe?s Intensive Care Medicine 7th edition
de Lemos JA and Morrow DA (2011), William and Wilkins
Unstable Angina and Non-ST Elevation Myocardial Infarction in Hurst's the Heart, 13th ed
de Lemos JA, O'Rourke RA, Harrington RA (2011), McGraw Hill
Cardiovascular Therapeutics: A companion to Braunwald's Heart Disease, 3rd ed
de Lemos JA (2007), Saunders
Biomarkers in Heart Disease
de Lemos JA (2008), Blackwell Publishing
- ST Elevation Myocardial infarction in Irwin and Rippe?s Intensive Care Medicine 7th edition
Relation of osteoprotegerin to coronary calcium and aortic plaque (from the Dallas Heart Study).
Abedin M, Omland T, Ueland T, Khera A, Aukrust P, Murphy SA, Jain T, Gruntmanis U, McGuire DK, de Lemos JA The American journal of cardiology 2007 Feb 99 4 513-8
Relation of family history of myocardial infarction and the presence of coronary arterial calcium in various age and risk factor groups.
Philips B, de Lemos JA, Patel MJ, McGuire DK, Khera A The American journal of cardiology 2007 Mar 99 6 825-9
HDL cholesterol: physiology, pathophysiology, and management.
Link JJ, Rohatgi A, de Lemos JA Current problems in cardiology 2007 May 32 5 268-314
Effect of glucose-insulin-potassium (GIK) infusion on biomarkers of cardiovascular risk in ST elevation myocardial infarction (STEMI): insight into the failure of GIK.
Parikh SV, Abdullah SM, Keeley EC, Cigarroa JE, Addo TA, Warner JJ, Khera A, de Lemos JA, McGuire DK Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2007 Sep 4 3 222-5
Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study.
Zirlik A, Abdullah SM, Gerdes N, MacFarlane L, Schönbeck U, Khera A, McGuire DK, Vega GL, Grundy S, Libby P, de Lemos JA Arteriosclerosis, thrombosis, and vascular biology 2007 Sep 27 9 2043-9
Estimated glomerular filtration rate, inflammation, and cardiovascular events after an acute coronary syndrome.
Mielniczuk LM, Pfeffer MA, Lewis EF, Blazing MA, de Lemos JA, Shui A, Mohanavelu S, Califf RM, Braunwald E American heart journal 2008 Apr 155 4 725-31
Amino-terminal pro-B-type natriuretic peptides in stable and unstable ischemic heart disease.
Omland T, de Lemos JA The American journal of cardiology 2008 Feb 101 3A 61-6
Changes in right ventricular structure and function assessed using cardiac magnetic resonance imaging in bosentan-treated patients with pulmonary arterial hypertension.
Chin KM, Kingman M, de Lemos JA, Warner JJ, Reimold S, Peshock R, Torres F The American journal of cardiology 2008 Jun 101 11 1669-72
Relation of troponin elevation to outcome in patients with infective endocarditis.
Purcell JB, Patel M, Khera A, de Lemos JA, Forbess LW, Baker S, Cabell CH, Peterson GE The American journal of cardiology 2008 May 101 10 1479-81
Application of the screening for Heart Attack Prevention and Education Task Force recommendations to an urban population: observations from the Dallas Heart Study.
See R, Lindsey JB, Patel MJ, Ayers CR, Khera A, McGuire DK, Grundy SM, de Lemos JA Archives of internal medicine 2008 May 168 10 1055-62
Association between renal function and circulating levels of natriuretic peptides (from the Dallas Heart Study).
Das SR, Abdullah SM, Leonard D, Drazner MH, Khera A, McGuire DK, de Lemos JA The American journal of cardiology 2008 Nov 102 10 1394-8
Outcomes of patients with acute coronary syndrome and previous coronary artery bypass grafting (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy [PROVE IT-TIMI 22] and the Aggrastat to Zocor [A to Z] trials).
Brilakis ES, de Lemos JA, Cannon CP, Wiviott SD, Murphy SA, Morrow DA, Sabatine MS, Banerjee S, Blazing MA, Califf RM, Braunwald E The American journal of cardiology 2008 Sep 102 5 552-8
Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors: results from the Dallas Heart Study.
Tsimikas S, Clopton P, Brilakis ES, Marcovina SM, Khera A, Miller ER, de Lemos JA, Witztum JL Circulation 2009 Apr 119 13 1711-9
Systems-based improvement in door-to-balloon times at a large urban teaching hospital: a follow-up study from Parkland Health and Hospital System.
Parikh SV, Treichler DB, DePaola S, Sharpe J, Valdes M, Addo T, Das SR, McGuire DK, de Lemos JA, Keeley EC, Warner JJ, Holper EM Circulation. Cardiovascular quality and outcomes 2009 Mar 2 2 116-22
Capturing the pathophysiology of acute coronary syndromes with circulating biomarkers.
McCullough PA, Peacock WF, O'Neil B, de Lemos JA Reviews in cardiovascular medicine 2010 11 Suppl 2 S3-12
Associations of four circulating chemokines with multiple atherosclerosis phenotypes in a large population-based sample: results from the dallas heart study.
Castillo L, Rohatgi A, Ayers CR, Owens AW, Das SR, Khera A, McGuire DK, de Lemos JA Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2010 May 30 5 339-47
Relation of level of B-type natriuretic peptide with outcomes in patients with infective endocarditis.
Shiue AB, Stancoven AB, Purcell JB, Pinkston K, Wang A, Khera A, de Lemos JA, Peterson GE The American journal of cardiology 2010 Oct 106 7 1011-5
Association of troponin T, detected with highly sensitive assay, and outcomes in infective endocarditis.
Stancoven AB, Shiue AB, Khera A, Pinkston K, Hashim IA, Wang A, de Lemos JA, Peterson GE The American journal of cardiology 2011 Aug 108 3 416-20
Impact of body weight and extreme obesity on the presentation, treatment, and in-hospital outcomes of 50,149 patients with ST-Segment elevation myocardial infarction results from the NCDR (National Cardiovascular Data Registry).
Das SR, Alexander KP, Chen AY, Powell-Wiley TM, Diercks DB, Peterson ED, Roe MT, de Lemos JA Journal of the American College of Cardiology 2011 Dec 58 25 2642-50
Pleiotropic effects of ezetimibe/simvastatin vs. high dose simvastatin.
Pesaro AE, Serrano CV, Fernandes JL, Cavalcanti AB, Campos AH, Martins HS, Maranhão RC, de Lemos JA, Souza HP, Nicolau JC International journal of cardiology 2011 Feb
Effect of concomitant use of clopidogrel and proton pump inhibitors after percutaneous coronary intervention.
Banerjee S, Weideman RA, Weideman MW, Little BB, Kelly KC, Gunter JT, Tortorice KL, Shank M, Cryer B, Reilly RF, Rao SV, Kastrati A, de Lemos JA, Brilakis ES, Bhatt DL The American journal of cardiology 2011 Mar 107 6 871-8
Enoxaparin versus unfractionated heparin in patients treated with tirofiban, aspirin and an early conservative initial management strategy: results from the A phase of the A to Z trial
47. de Lemos JA, Blazing MA, Wiviott SD, Brady WE, White HD, Fox KAA, Palmisano J, Ramsey KE, Bilheimer D, Lewis EF, Califf RM, Braunwald E Eur Heart J 2004 25 1688-94
Early Intensive vs a Delayed Conservative Simvastatin Strategy in Patients With Acute Coronary Syndromes: Phase Z of the A to Z Trial
46. de Lemos JA, Blazing MA, Wiviott SD, Lewis EF, Fox KA, White HD, Rouleau JL, Pedersen TR, Gardner LH, Mukherjee R, Ramsey KE, Palmisano J, Bilheimer DW, Pfeffer MA, Califf RM, Braunwald E JAMA 2004 292 1303-17
Relation of Coronary Atherosclerosis Determined by Electron Beam Computed Tomography and Plasma Levels of N-terminal Pro-Brain Natriuretic Peptide in a Multiethnic Population-Based Sample (The Dallas Heart Study)
59. Abdullah SM, Khera A, Das SR, Stanek HG, Canham RM, Chung AK, Morrow DA, Drazner MH, McGuire DK, de Lemos JA Am J Cardiol 2004 96 1284-9
Associations Between Soluble CD40 Ligand, Atherosclerosis Risk Factors, and Subclinical Atherosclerosis: Results from the Dallas Heart Study.
58. de Lemos, JA, Zirlik A, Schonbeck U, Varo N, Murphy S, Khera A, McGuire DK, Stanek G, Lo H, Nuzzo R, Morrow DA, Peshock R, Libby P. ATVB 2005 25 2192-6
Prognostic Value of B-type Natriuretic Peptide During Follow-up of Patients with Unstable Coronary Artery Disease in the A to Z Trial
60. Morrow DA, de Lemos JA, Blazing MA, Sabatine MS, Murphy SA, Jarolim P, White HD, Fox KAA, Califf RM, Braunwald E JAMA 2005 294 2866-71
Prevalence and Determinants of Troponin T Elevation in the General Population
64. Wallace TW, Abdullah S, Drazner MH, Das SR, Khera A, McGuire DK, Wians F, Sabatine MS, Morrow DA, de Lemos JA Circulation 2006 113 1958-65
Evaluation of the National Cholesterol Education Program Adult Treatment Panel III algorithm for selecting candidates for statin therapy: Insights from the A to Z trial
70. de Lemos JA, Wiviott SD, Murphy SA, Blazing MA, Lewis EF, Califf RM. Pfeffer MA, Braunwald E Am J Cardiol 2006 98 739-42
Statins and cardiovascular risk reduction in patients with chronic kidney disease and end-stage renal failure.
Baber U, Toto RD, de Lemos JA American heart journal 2007 Apr 153 4 471-7
Use of natriuretic peptides in clinical decision-making for patients with non-ST-elevation acute coronary syndromes.
de Lemos JA, Morrow DA American heart journal 2007 Apr 153 4 450-3
Diagnostic and prognostic utility of brain natriuretic Peptide in subjects admitted to the ICU with hypoxic respiratory failure due to noncardiogenic and cardiogenic pulmonary edema.
Karmpaliotis D, Kirtane AJ, Ruisi CP, Polonsky T, Malhotra A, Talmor D, Kosmidou I, Jarolim P, de Lemos JA, Sabatine MS, Gibson CM, Morrow D Chest 2007 Apr 131 4 964-71
The association of differing measures of overweight and obesity with prevalent atherosclerosis: the Dallas Heart Study.
See R, Abdullah SM, McGuire DK, Khera A, Patel MJ, Lindsey JB, Grundy SM, de Lemos JA Journal of the American College of Cardiology 2007 Aug 50 8 752-9
Sex differences in the association between leptin and CRP: results from the Dallas Heart Study.
Abdullah SM, Khera A, Leonard D, Das SR, Canham RM, Kamath SA, Vega GL, Grundy SM, McGuire DK, de Lemos JA Atherosclerosis 2007 Dec 195 2 404-10
Benchmarks for the assessment of novel cardiovascular biomarkers.
Morrow DA, de Lemos JA Circulation 2007 Feb 115 8 949-52
Plasma osteoprotegerin levels in the general population: relation to indices of left ventricular structure and function.
Omland T, Drazner MH, Ueland T, Abedin M, Murphy SA, Aukrust P, de Lemos JA Hypertension 2007 Jun 49 6 1392-8
Left ventricular hypertrophy, subclinical atherosclerosis, and inflammation.
Mehta SK, Rame JE, Khera A, Murphy SA, Canham RM, Peshock RM, de Lemos JA, Drazner MH Hypertension 2007 Jun 49 6 1385-91
High-dose alpha-tocopherol therapy does not affect HDL subfractions in patients with coronary artery disease on statin therapy.
Singh U, Otvos J, Dasgupta A, de Lemos JA, Devaraj S, Jialal I Clinical chemistry 2007 Mar 53 3 525-8
Effect of high-dose alpha-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease.
Devaraj S, Tang R, Adams-Huet B, Harris A, Seenivasan T, de Lemos JA, Jialal I The American journal of clinical nutrition 2007 Nov 86 5 1392-8
The skinny on fatty acid-binding protein.
de Lemos JA, O'Donoghue M Journal of the American College of Cardiology 2007 Nov 50 21 2068-70
Serial measurement of monocyte chemoattractant protein-1 after acute coronary syndromes: results from the A to Z trial.
de Lemos JA, Morrow DA, Blazing MA, Jarolim P, Wiviott SD, Sabatine MS, Califf RM, Braunwald E Journal of the American College of Cardiology 2007 Nov 50 22 2117-24
Clinical application of C-reactive protein across the spectrum of acute coronary syndromes.
Scirica BM, Morrow DA, Cannon CP, de Lemos JA, Murphy S, Sabatine MS, Wiviott SD, Rifai N, McCabe CH, Braunwald E Clinical chemistry 2007 Oct 53 10 1800-7
Effect of intensive lipid-lowering therapy on mortality after acute coronary syndrome (a patient-level analysis of the Aggrastat to Zocor and Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 trials).
Murphy SA, Cannon CP, Wiviott SD, de Lemos JA, Blazing MA, McCabe CH, Califf RM, Braunwald E The American journal of cardiology 2007 Oct 100 7 1047-51
Antiplatelet agents make a comeback in ST-elevation myocardial infarction.
Wiviott SD, de Lemos JA American heart journal 2007 Oct 154 4 603-6
Implications of family history of myocardial infarction in young women.
Patel MJ, de Lemos JA, Philips B, Murphy SA, Vaeth PC, McGuire DK, Khera A American heart journal 2007 Sep 154 3 454-60
Use and misuse of cardiac troponins in clinical practice.
Gupta S, de Lemos JA Progress in cardiovascular diseases 2007 Sep-Oct 50 2 151-65
Management of cocaine-associated chest pain and myocardial infarction: a scientific statement from the American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology.
McCord J, Jneid H, Hollander JE, de Lemos JA, Cercek B, Hsue P, Gibler WB, Ohman EM, Drew B, Philippides G, Newby LK Circulation 2008 Apr 117 14 1897-907
Association of lipoprotein-associated phospholipase A2 mass and activity with coronary and aortic atherosclerosis: findings from the Dallas Heart Study.
Brilakis ES, Khera A, Saeed B, Banerjee S, McGuire DK, Murphy SA, de Lemos JA Clinical chemistry 2008 Dec 54 12 1975-81
Cardiovascular risk indicators and perceived race/ethnic discrimination in the Dallas Heart Study.
Albert MA, Ravenell J, Glynn RJ, Khera A, Halevy N, de Lemos JA American heart journal 2008 Dec 156 6 1103-9
Amino-terminal pro-B-type natriuretic peptides: testing in general populations.
de Lemos JA, Hildebrandt P The American journal of cardiology 2008 Feb 101 3A 16-20
The effect of a disease management algorithm and dedicated postacute coronary syndrome clinic on achievement of guideline compliance: results from the parkland acute coronary event treatment study.
Yorio J, Viswanathan S, See R, Uchal L, McWhorter JA, Spencer N, Murphy S, Khera A, de Lemos JA, McGuire DK Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2008 Jan 56 1 15-25
Sorting through new biomarkers.
Wood FO, de Lemos JA Current cardiology reports 2008 Jul 10 4 319-26
Influence of race and sex on lipoprotein-associated phospholipase A2 levels: observations from the Dallas Heart Study.
Brilakis ES, Khera A, McGuire DK, See R, Banerjee S, Murphy SA, de Lemos JA Atherosclerosis 2008 Jul 199 1 110-5
Independent associations between metabolic syndrome, diabetes mellitus and atherosclerosis: observations from the Dallas Heart Study.
Chen K, Lindsey JB, Khera A, De Lemos JA, Ayers CR, Goyal A, Vega GL, Murphy SA, Grundy SM, McGuire DK Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2008 Jun 5 2 96-101
Thrombus precursor protein and clinical outcomes in patients with acute coronary syndromes.
Mega JL, Morrow DA, de Lemos JA, Mohanavelu S, Cannon CP, Sabatine MS Journal of the American College of Cardiology 2008 Jun 51 25 2422-9
Non-traditional risk factors predict coronary calcification in chronic kidney disease in a population-based cohort.
Baber U, de Lemos JA, Khera A, McGuire DK, Omland T, Toto RD, Hedayati SS Kidney international 2008 Mar 73 5 615-21
Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18.
Morrow DA, Sabatine MS, Brennan ML, de Lemos JA, Murphy SA, Ruff CT, Rifai N, Cannon CP, Hazen SL European heart journal 2008 May 29 9 1096-102
Multiple biomarker panels for cardiovascular risk assessment.
de Lemos JA, Lloyd-Jones DM The New England journal of medicine 2008 May 358 20 2172-4
Differences in the inflammatory response between patients with and those without diabetes mellitus after coronary stenting.
Paiva MS, Serrano CV, Nicolau JC, Jalbut BO, Fernandes JL, De Lemos JA, Blotta MH, De Oliveira RT, De Oliveira IR, De Oliveira Lda A, Ramires JA Journal of interventional cardiology 2008 Oct 21 5 403-9
The association between plasma caspase-3, atherosclerosis, and vascular function in the Dallas Heart Study.
Matulevicius S, Rohatgi A, Khera A, Das SR, Owens A, Ayers CR, Timaran CH, Rosero EB, Drazner MH, Peshock RM, de Lemos JA Apoptosis : an international journal on programmed cell death 2008 Oct 13 10 1281-9
The association between peptidoglycan recognition protein-1 and coronary and peripheral atherosclerosis: Observations from the Dallas Heart Study.
Rohatgi A, Ayers CR, Khera A, McGuire DK, Das SR, Matulevicius S, Timaran CH, Rosero EB, de Lemos JA Atherosclerosis 2009 Apr 203 2 569-75
Screening the population for left ventricular hypertrophy and left ventricular systolic dysfunction using natriuretic peptides: results from the Dallas Heart Study.
de Lemos JA, McGuire DK, Khera A, Das SR, Murphy SA, Omland T, Drazner MH American heart journal 2009 Apr 157 4 746-53.e2
Keeping our eyes on the prize: low density lipoprotein cholesterol.
de Lemos JA, Khera A The American journal of cardiology 2009 Dec 104 12 1697-8
A sensitive cardiac troponin T assay in stable coronary artery disease.
Omland T, de Lemos JA, Sabatine MS, Christophi CA, Rice MM, Jablonski KA, Tjora S, Domanski MJ, Gersh BJ, Rouleau JL, Pfeffer MA, Braunwald E The New England journal of medicine 2009 Dec 361 26 2538-47
Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35.
Sabatine MS, Morrow DA, de Lemos JA, Jarolim P, Braunwald E European heart journal 2009 Jan 30 2 162-9
Hemodynamics and epoprostenol use are associated with thrombocytopenia in pulmonary arterial hypertension.
Chin KM, Channick RN, de Lemos JA, Kim NH, Torres F, Rubin LJ Chest 2009 Jan 135 1 130-6
Biomarkers and cardiovascular disease: determining causality and quantifying contribution to risk assessment.
Shah SH, de Lemos JA JAMA : the journal of the American Medical Association 2009 Jul 302 1 92-3
Association between circulating soluble receptor for advanced glycation end products and atherosclerosis: observations from the Dallas Heart Study.
Lindsey JB, de Lemos JA, Cipollone F, Ayers CR, Rohatgi A, Morrow DA, Khera A, McGuire DK Diabetes care 2009 Jul 32 7 1218-20
The report card on growth differentiation factor 15: consistent marks but not yet ready for promotion.
Rohatgi A, de Lemos JA Circulation. Cardiovascular genetics 2009 Jun 2 3 209-11
Native LDL-cholesterol mediated monocyte adhesion molecule overexpression is blocked by simvastatin.
Serrano CV, Pesaro AE, de Lemos JA, Rached F, Segre CA, Gomes F, Ribeiro AF, Nicolau JC, Yoshida VM, Monteiro HP Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2009 Jun 23 3 215-20
Evaluation of coronary artery calcium screening strategies focused on risk categories: the Dallas Heart Study.
Patel MJ, de Lemos JA, McGuire DK, See R, Lindsey JB, Murphy SA, Grundy SM, Khera A American heart journal 2009 Jun 157 6 1001-9
A randomized controlled trial of a paclitaxel-eluting stent versus a similar bare-metal stent in saphenous vein graft lesions the SOS (Stenting of Saphenous Vein Grafts) trial.
Brilakis ES, Lichtenwalter C, de Lemos JA, Roesle M, Obel O, Haagen D, Saeed B, Gadiparthi C, Bissett JK, Sachdeva R, Voudris VV, Karyofillis P, Kar B, Rossen J, Fasseas P, Berger P, Banerjee S Journal of the American College of Cardiology 2009 Mar 53 11 919-28
Association of cystatin C with left ventricular structure and function: the Dallas Heart Study.
Patel PC, Ayers CR, Murphy SA, Peshock R, Khera A, de Lemos JA, Balko JA, Gupta S, Mammen PP, Drazner MH, Markham DW Circulation. Heart failure 2009 Mar 2 2 98-104
Fracture and embolization of an inferior vena cava filter strut leading to cardiac tamponade.
Rogers NA, Nguyen L, Minniefield NE, Jessen ME, de Lemos JA Circulation 2009 May 119 18 2535-6
Acute decline in renal function, inflammation, and cardiovascular risk after an acute coronary syndrome.
Mielniczuk LM, Pfeffer MA, Lewis EF, Blazing MA, de Lemos JA, Mohanavelu S, Rouleau J, Fox K, Pedersen TR, Califf RM Clinical journal of the American Society of Nephrology : CJASN 2009 Nov 4 11 1811-7
Newer biomarkers in heart failure.
Gupta S, Drazner MH, de Lemos JA Heart failure clinics 2009 Oct 5 4 579-88
Differential associations between soluble cellular adhesion molecules and atherosclerosis in the Dallas Heart Study: a distinct role for soluble endothelial cell-selective adhesion molecule.
Rohatgi A, Owens AW, Khera A, Ayers CR, Banks K, Das SR, Berry JD, McGuire DK, de Lemos JA Arteriosclerosis, thrombosis, and vascular biology 2009 Oct 29 10 1684-90
Clinical presentation and angiographic characteristics of saphenous vein graft failure after stenting: insights from the SOS (stenting of saphenous vein grafts) trial.
Lichtenwalter C, de Lemos JA, Roesle M, Obel O, Holper EM, Haagen D, Saeed B, Iturbe JM, Shunk K, Bissett JK, Sachdeva R, Voudris VV, Karyofillis P, Kar B, Rossen J, Fasseas P, Berger P, Banerjee S, Brilakis ES JACC. Cardiovascular interventions 2009 Sep 2 9 855-60
Sex differences in the relationship between C-reactive protein and body fat.
Khera A, Vega GL, Das SR, Ayers C, McGuire DK, Grundy SM, de Lemos JA The Journal of clinical endocrinology and metabolism 2009 Sep 94 9 3251-8
Should we focus on novel risk markers and screening tests to better predict and prevent cardiovascular disease? Point.
Enriquez JR, de Lemos JA Preventive cardiology 2010 13 4 152-9
Natriuretic peptides in the prognosis and management of acute coronary syndromes.
de Lemos JA, Peacock WF, McCullough PA Reviews in cardiovascular medicine 2010 11 Suppl 2 S24-34
An evidence-based algorithm for the use of B-type natriuretic testing in acute coronary syndromes.
McCullough PA, Peacock WF, O'Neil B, de Lemos JA, Lepor NE, Berkowitz R Reviews in cardiovascular medicine 2010 11 Suppl 2 S51-65
Timing of in-hospital coronary artery bypass graft surgery for non-ST-segment elevation myocardial infarction patients results from the National Cardiovascular Data Registry ACTION Registry-GWTG (Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines).
Parikh SV, de Lemos JA, Jessen ME, Brilakis ES, Ohman EM, Chen AY, Wang TY, Peterson ED, Roe MT, Holper EM JACC. Cardiovascular interventions 2010 Apr 3 4 419-27
Contemporary use of embolic protection devices in saphenous vein graft interventions: Insights from the stenting of saphenous vein grafts trial.
Badhey N, Lichtenwalter C, de Lemos JA, Roesle M, Obel O, Addo TA, Haagen D, Abdel-Karim AR, Saeed B, Bissett JK, Sachdeva R, Voudris VV, Karyofillis P, Kar B, Rossen J, Fasseas P, Berger PB, Banerjee S, Brilakis ES Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2010 Aug 76 2 263-9
Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults.
deFilippi CR, de Lemos JA, Christenson RH, Gottdiener JS, Kop WJ, Zhan M, Seliger SL JAMA : the journal of the American Medical Association 2010 Dec 304 22 2494-502
Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population.
de Lemos JA, Drazner MH, Omland T, Ayers CR, Khera A, Rohatgi A, Hashim I, Berry JD, Das SR, Morrow DA, McGuire DK JAMA : the journal of the American Medical Association 2010 Dec 304 22 2503-12
Separating the contenders from the pretenders: competitive high-throughput biomarker screening in large population-based studies.
de Lemos JA, Rohatgi A Circulation 2010 Jun 121 22 2381-3
Left ventricular hypertrophy, aortic wall thickness, and lifetime predicted risk of cardiovascular disease:the Dallas Heart Study.
Gupta S, Berry JD, Ayers CR, Peshock RM, Khera A, de Lemos JA, Patel PC, Markham DW, Drazner MH JACC. Cardiovascular imaging 2010 Jun 3 6 605-13
A 4-tiered classification of left ventricular hypertrophy based on left ventricular geometry: the Dallas heart study.
Khouri MG, Peshock RM, Ayers CR, de Lemos JA, Drazner MH Circulation. Cardiovascular imaging 2010 Mar 3 2 164-71
B-type natriuretic peptide and the effect of ranolazine in patients with non-ST-segment elevation acute coronary syndromes: observations from the MERLIN-TIMI 36 (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST Elevation Acute Coronary-Thrombolysis In Myocardial Infarction 36) trial.
Morrow DA, Scirica BM, Sabatine MS, de Lemos JA, Murphy SA, Jarolim P, Theroux P, Bode C, Braunwald E Journal of the American College of Cardiology 2010 Mar 55 12 1189-96
Troponin-positive, MB-negative patients with non-ST-elevation myocardial infarction: An undertreated but high-risk patient group: Results from the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network-Get With The Guidelines (NCDR ACTION-GWTG) Registry.
Kontos MC, de Lemos JA, Ou FS, Wiviott SD, Foody JM, Newby LK, Chen A, Roe MT American heart journal 2010 Nov 160 5 819-25
Body size misperception: a novel determinant in the obesity epidemic.
Powell TM, de Lemos JA, Banks K, Ayers CR, Rohatgi A, Khera A, McGuire DK, Berry JD, Albert MA, Vega GL, Grundy SM, Das SR Archives of internal medicine 2010 Oct 170 18 1695-7
Circulating lymphotoxin ß receptor and atherosclerosis: observations from the Dallas Heart Study.
Owens AW, Matulevicius S, Rohatgi A, Ayers CR, Das SR, Khera A, McGuire DK, de Lemos JA Atherosclerosis 2010 Oct 212 2 601-6
Randomized comparison of the effects of rosiglitazone vs. placebo on peak integrated cardiovascular performance, cardiac structure, and function.
McGuire DK, Abdullah SM, See R, Snell PG, McGavock J, Szczepaniak LS, Ayers CR, Drazner MH, Khera A, de Lemos JA European heart journal 2010 Sep 31 18 2262-70
Assessment of cardiac structure and function in patients without and with peripheral oedema during rosiglitazone treatment.
Narang N, Armstead SI, Stream A, Abdullah SM, See R, Snell PG, McGavock J, Ayers CR, Gore MO, Khera A, de Lemos JA, McGuire DK Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2011 Apr 8 2 101-8
Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study.
Saunders JT, Nambi V, de Lemos JA, Chambless LE, Virani SS, Boerwinkle E, Hoogeveen RC, Liu X, Astor BC, Mosley TH, Folsom AR, Heiss G, Coresh J, Ballantyne CM Circulation 2011 Apr 123 13 1367-76
Cardiorespiratory fitness and classification of risk of cardiovascular disease mortality.
Gupta S, Rohatgi A, Ayers CR, Willis BL, Haskell WL, Khera A, Drazner MH, de Lemos JA, Berry JD Circulation 2011 Apr 123 13 1377-83
Lifetime risks for cardiovascular disease mortality by cardiorespiratory fitness levels measured at ages 45, 55, and 65 years in men. The Cooper Center Longitudinal Study.
Berry JD, Willis B, Gupta S, Barlow CE, Lakoski SG, Khera A, Rohatgi A, de Lemos JA, Haskell W, Lloyd-Jones DM Journal of the American College of Cardiology 2011 Apr 57 15 1604-10
Biomarkers in clinical trials: can we move from fortune telling to disease profiling?
de Lemos JA, McGuire DK Circulation 2011 Aug 124 6 663-5
Race-specific associations of myeloperoxidase with atherosclerosis in a population-based sample: the Dallas Heart Study.
Chen LQ, Rohatgi A, Ayers CR, Das SR, Khera A, Berry JD, McGuire DK, de Lemos JA Atherosclerosis 2011 Dec 219 2 833-8
No free lunches: balancing bleeding and efficacy with ticagrelor.
de Lemos JA, Brilakis ES European heart journal 2011 Dec 32 23 2919-21
Continued benefit from paclitaxel-eluting compared with bare-metal stent implantation in saphenous vein graft lesions during long-term follow-up of the SOS (Stenting of Saphenous Vein Grafts) trial.
Brilakis ES, Lichtenwalter C, Abdel-karim AR, de Lemos JA, Obel O, Addo T, Roesle M, Haagen D, Rangan BV, Saeed B, Bissett JK, Sachdeva R, Voudris VV, Karyofillis P, Kar B, Rossen J, Fasseas P, Berger P, Banerjee S JACC. Cardiovascular interventions 2011 Feb 4 2 176-82
Updated evidence on early statin therapy for acute coronary syndromes: Meta-analysis of 18 randomized trials involving over 14,000 patients.
Briel M, Vale N, Schwartz GG, de Lemos JA, Colivicchi F, den Hartog FR, Ostadal P, Macin SM, Liem A, Mills E, Bhatnagar N, Bucher HC, Nordmann AJ International journal of cardiology 2011 Feb
Clinical characteristics, vascular function, and inflammation in women with angina in the absence of coronary atherosclerosis: the Dallas Heart Study.
Banks K, Puttagunta D, Murphy S, Lo M, McGuire DK, de Lemos JA, Chang AY, Grundy SM, Khera A JACC. Cardiovascular imaging 2011 Jan 4 1 65-73
Polycystic ovarian syndrome and subclinical atherosclerosis among women of reproductive age in the Dallas heart study.
Chang AY, Ayers C, Minhajuddin A, Jain T, Nurenberg P, de Lemos JA, Wild RA, Auchus RJ Clinical endocrinology 2011 Jan 74 1 89-96
Distribution of hepatitis C virus genotypes among different exposure categories in the State of Pará, Brazilian Amazon.
Sawada L, Pinheiro AC, Locks D, Pimenta Ado S, Rezende PR, Crespo DM, Crescente JÂ, de Lemos JA, de Oliveira Filho AB Revista da Sociedade Brasileira de Medicina Tropical 2011 Jan-Feb 44 1 8-12
Highly sensitive troponin assays and the cardiology community: a love/hate relationship?
de Lemos JA, Morrow DA, deFilippi CR Clinical chemistry 2011 Jun 57 6 826-9
Recurrent cardiovascular events with paclitaxel-eluting versus bare-metal stents in saphenous vein graft lesions: insights from the SOS (Stenting of Saphenous Vein Grafts) trial.
Michael TT, Abdel-karim AR, Papayannis A, Lichtenwalter C, de Lemos JA, Obel O, Addo T, Roesle M, Haagen D, Rangan BV, Saeed B, Bissett JK, Sachdeva R, Voudris VV, Karyofillis P, Kar B, Rossen J, Fasseas P, Berger PB, Banerjee S, Brilakis ES The Journal of invasive cardiology 2011 Jun 23 6 216-9
Assessment of adiponectin and the risk of recurrent cardiovascular events in patients presenting with an acute coronary syndrome: observations from the Pravastatin Or atorVastatin Evaluation and Infection Trial-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22).
Wilson SR, Sabatine MS, Wiviott SD, Ray KK, De Lemos JA, Zhou S, Rifai N, Cannon CP, Morrow DA American heart journal 2011 Jun 161 6 1147-55.e1
Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study.
Turer AT, Addo TA, Martin JL, Sabatine MS, Lewis GD, Gerszten RE, Keeley EC, Cigarroa JE, Lange RA, Hillis LD, de Lemos JA Journal of the American College of Cardiology 2011 Jun 57 24 2398-405
Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis.
Preiss D, Seshasai SR, Welsh P, Murphy SA, Ho JE, Waters DD, DeMicco DA, Barter P, Cannon CP, Sabatine MS, Braunwald E, Kastelein JJ, de Lemos JA, Blazing MA, Pedersen TR, Tikkanen MJ, Sattar N, Ray KK JAMA : the journal of the American Medical Association 2011 Jun 305 24 2556-64
Risk scores versus natriuretic peptides for identifying prevalent stage B heart failure.
Gupta S, Rohatgi A, Ayers CR, Patel PC, Matulevicius SA, Peshock RM, Markham DW, de Lemos JA, Berry JD, Drazner MH American heart journal 2011 May 161 5 923-930.e2
Association of growth differentiation factor-15 with coronary atherosclerosis and mortality in a young, multiethnic population: observations from the Dallas Heart Study.
Rohatgi A, Patel P, Das SR, Ayers CR, Khera A, Martinez-Rumayor A, Berry JD, McGuire DK, de Lemos JA Clinical chemistry 2012 Jan 58 1 172-82
Low levels of circulating troponin as an intermediate phenotype in the pathway to heart failure.
de Lemos JA, Grundy SM Journal of the American College of Cardiology 2012 Jan 59 5 490-2
Abciximab improves both epicardial flow and myocardial reperfusion in ST elevation myocardial infarction: observations from the TIMI 14 trial
de Lemos JA, Antman EM, Gibson CM, McCabe CH, Giugliano RP, Murphy SA, Coulter SA, Anderson K, Scherer J, Frey M, Van der Wieken R, Van de Werf F, MD, Braunwald E Circulation December 2000 101 239-43
ST resolution and infarct related artery patency and flow after thrombolytic therapy
de Lemos JA, Antman EM, Giugliano RP, McCabe CH, Murphy SA, Gibson CM, Braunwald E American Journal of Cardiology November 2000 85 299-304
The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes
de Lemos JA, Morrow DA, Bentley JH, Omland T, Sabatine MS, McCabe CH, Hall C, Cannon CP, Braunwald E New England Journal of Medicine September 2001 345 1014-21
- Relation of osteoprotegerin to coronary calcium and aortic plaque (from the Dallas Heart Study).
- Screening for Cardiovascular Disease
- Lipid Lowering Therapy
- Cardiac Biomarkers
- Acute Coronary Syndromes
- General Cardiology
Q&A by Dr. de Lemos
AHA Scientific Sessions: Dr. James de Lemos
At the 2017 American Heart Association Scientific Sessions, James de Lemos, MD from UT Southwestern Medical Center discusses a new blood test for diagnosing heart attacks that will allow healthcare professionals to rule out myocardial infractions in significantly less time.