Xiao-Fei Kong, M.D., Ph.D.

Internal Medicine - Digestive and Liver Diseases
Celiac Disease
Common variable immunodeficiency

Biography

Xiao-Fei Kong, M.D., Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center. He specializes in celiac disease, common variable immunodeficiency, Down syndrome, inflammatory bowel disease, and rare liver disease.

Originally from China, Dr. Kong was educated and trained across three continents. He earned his medical degree at Yangzhou University Medical College in Jiangsu, China, and completed a residency in internal medicine at Ruijin Hospital and Shanghai Jiaotong University. He then obtained a doctoral degree in immunology and genetics from the Sorbonne University in Paris, France, under the mentorship of Jean-Laurent Casanova, M.D., Ph.D. As a clinical scholar, Dr. Kong earned a master's degree in translational medicine from the Rockefeller University in New York. He then received additional internal medicine residency training at the Icahn School of Medicine at Mount Sinai, also in New York, followed by advanced fellowship training in gastroenterology and a one-year faculty appointment at Columbia University Medical Center.

Certified by the American Board of Internal Medicine in internal medicine and gastroenterology, he joined the UT Southwestern faculty in 2022.

An investigator on numerous clinical projects, Dr. Kong's research interests include celiac disease, inflammatory bowel disease, inborn errors of immunity, and rare liver diseases. His work has led to the discovery of several new genetic diseases, including human SPPL2A deficiency, inherited STAT1 disorders, and interferonopathy in Down syndrome. He has published numerous articles in peer-reviewed journals and presented widely at national and international conferences.

Dr. Kong is an active member of several professional organizations, including the American Association for the Study of Liver Diseases, the American Gastroenterological Association, and the European Society for Immunodeficiencies.

In 2021, he received a career development award from the National Institute of Diabetes and Digestive and Kidney Diseases.

Education & Training

Medical School - Yangzhou University Medical College (1996-2001)
Other Post Graduate Training - The Rockefeller University (2012-2015)
Residency - Icahn School of Medicine at Mount Sinai /Queens Hospital Center (2015-2018), Internal Medicine
Fellowship - Columbia University - New York Presbyterian Hospital (2018-2021), Gastroenterology

Professional Associations & Affiliations

American Association for the Study of Liver Diseases
American Gastroenterological Association
Clinical Immunology Society
European Society for Immunodeficiencies

Honors & Awards

Clinical and Translational Science Award 2014, The Rockefeller University
Jérôme Lejeune Foundation Award 2013
Stony Wold-Herbert Fund Award 2012
C. H. Li Memorial Scholar Award 2009, The Rockefeller University
Keystone Symposia Travel Award 2009
Chen-Guang Plan Scholar 2007, Shanghai Education Development Foundation
First-Prize Scholarship 2004, Shanghai Jiaotong University, School of Medicine

Books & Publications

Publications
- The diagnostic yield of exome sequencing in liver diseases from a curated gene panel.
  Kong XF, Bogyo K, Kapoor S, Shea PR, Groopman EE, Thomas-Wilson A, Cocchi E, Milo Rasouly H, Zheng B, Sun S, Zhang J, Martinez M, Vittorio JM, Dove LM, Marasa M, Wang TC, Verna EC, Worman HJ, Gharavi AG, Goldstein DB, Wattacheril J, Scientific reports 2023 Dec 13 1 21540
- Serological Investigation of Persistent Villous Atrophy in Celiac Disease.
  Gong C, Saborit C, Long X, Wang A, Zheng B, Chung H, Lewis SK, Krishnareddy S, Bhagat G, Green PHR, Kong XF, Clinical and translational gastroenterology 2023 Sep
- Immunogenetics of gastrointestinal cancers: A systematic review and retrospective survey of inborn errors of immunity in humans.
  Zheng B, Artin MG, Chung H, Chen B, Sun S, May BL, Hur C, Green PHR, Wang TC, Park J, Kong XF, Journal of gastroenterology and hepatology 2022 Jun 37 6 973-982
- Individuals with Down syndrome hospitalized with COVID-19 have more severe disease.
  Malle L, Gao C, Hur C, Truong HQ, Bouvier NM, Percha B, Kong XF, Bogunovic D, Genetics in medicine : official journal of the American College of Medical Genetics 2021 03 23 3 576-580
- Interferon-Driven Immune Dysregulation in Down Syndrome: A Review of the Evidence.
  Chung H, Green PHR, Wang TC, Kong XF, Journal of inflammation research 2021 14 5187-5200
- Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome.
  Kong XF, Worley L, Rinchai D, Bondet V, Jithesh PV, Goulet M, Nonnotte E, Rebillat AS, Conte M, Mircher C, Gürtler N, Liu L, Migaud M, Elanbari M, Habib T, Ma CS, Bustamante J, Abel L, Ravel A, Lyonnet S, Munnich A, Duffy D, Chaussabel D, Casanova JL, Tangye SG, Boisson-Dupuis S, Puel A, Journal of clinical immunology 2020 Jun
- A deep intronic splice mutation of STAT3 underlies hyper IgE syndrome by negative dominance.
  Khourieh J, Rao G, Habib T, Avery DT, Lefèvre-Utile A, Chandesris MO, Belkadi A, Chrabieh M, Alwaseem H, Grandin V, Sarrot-Reynauld F, Sénéchal A, Lortholary O, Kong XF, Boisson-Dupuis S, Picard C, Puel A, Béziat V, Zhang Q, Abel L, Molina H, Marr N, Tangye SG, Casanova JL, Boisson B, Proceedings of the National Academy of Sciences of the United States of America 2019 08 116 33 16463-16472
- The Light at the End of the Tunnel.
  Krigel A, Kong XF, Freedberg DE, Gastroenterology 2019 04 156 5 e10-e11
- Mendelian susceptibility to mycobacterial disease: 2014-2018 update.
  Rosain J, Kong XF, Martinez-Barricarte R, Oleaga-Quintas C, Ramirez-Alejo N, Markle J, Okada S, Boisson-Dupuis S, Casanova JL, Bustamante J, Immunology and cell biology 2019 04 97 4 360-367
- A purely quantitative form of partial recessive IFN-γR2 deficiency caused by mutations of the initiation or second codon.
  Oleaga-Quintas C, Deswarte C, Moncada-Vélez M, Metin A, Krishna Rao I, Kanik-Yüksek S, Nieto-Patlán A, Guérin A, Gülhan B, Murthy S, Özkaya-Parlakay A, Abel L, Martínez-Barricarte R, Pérez de Diego R, Boisson-Dupuis S, Kong XF, Casanova JL, Bustamante J, Human molecular genetics 2019 02 28 3 524
- Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23.
  Martínez-Barricarte R, Markle JG, Ma CS, Deenick EK, Ramírez-Alejo N, Mele F, Latorre D, Mahdaviani SA, Aytekin C, Mansouri D, Bryant VL, Jabot-Hanin F, Deswarte C, Nieto-Patlán A, Surace L, Kerner G, Itan Y, Jovic S, Avery DT, Wong N, Rao G, Patin E, Okada S, Bigio B, Boisson B, Rapaport F, Seeleuthner Y, Schmidt M, Ikinciogullari A, Dogu F, Tanir G, Tabarsi P, Bloursaz MR, Joseph JK, Heer A, Kong XF, Migaud M, Lazarov T, Geissmann F, Fleckenstein B, Arlehamn CL, Sette A, Puel A, Emile JF, van de Vosse E, Quintana-Murci L, Di Santo JP, Abel L, Boisson-Dupuis S, Bustamante J, Tangye SG, Sallusto F, Casanova JL, Science immunology 2018 12 3 30
- A purely quantitative form of partial recessive IFN-γR2 deficiency caused by mutations of the initiation or second codon.
  Oleaga-Quintas C, Deswarte C, Moncada-Vélez M, Metin A, Krishna Rao I, Kanik-Yüksek S, Nieto-Patlán A, Guérin A, Gülhan B, Murthy S, Özkaya-Parlakay A, Abel L, Martínez-Barricarte R, Pérez de Diego R, Boisson-Dupuis S, Kong XF, Casanova JL, Bustamante J, Human molecular genetics 2018 11 27 22 3919-3935
- Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency.
  Kong XF, Martinez-Barricarte R, Kennedy J, Mele F, Lazarov T, Deenick EK, Ma CS, Breton G, Lucero KB, Langlais D, Bousfiha A, Aytekin C, Markle J, Trouillet C, Jabot-Hanin F, Arlehamn CSL, Rao G, Picard C, Lasseau T, Latorre D, Hambleton S, Deswarte C, Itan Y, Abarca K, Moraes-Vasconcelos D, Ailal F, Ikinciogullari A, Dogu F, Benhsaien I, Sette A, Abel L, Boisson-Dupuis S, Schröder B, Nussenzweig MC, Liu K, Geissmann F, Tangye SG, Gros P, Sallusto F, Bustamante J, Casanova JL, Nature immunology 2018 09 19 9 973-985
- Alanine-scanning mutagenesis of human signal transducer and activator of transcription 1 to estimate loss- or gain-of-function variants.
  Kagawa R, Fujiki R, Tsumura M, Sakata S, Nishimura S, Itan Y, Kong XF, Kato Z, Ohnishi H, Hirata O, Saito S, Ikeda M, El Baghdadi J, Bousfiha A, Fujiwara K, Oleastro M, Yancoski J, Perez L, Danielian S, Ailal F, Takada H, Hara T, Puel A, Boisson-Dupuis S, Bustamante J, Casanova JL, Ohara O, Okada S, Kobayashi M, The Journal of allergy and clinical immunology 2017 Jul 140 1 232-241
- Interferon-γ Autoantibodies as Predisposing Factor for Nontuberculous Mycobacterial Infection.
  Valour F, Perpoint T, Sénéchal A, Kong XF, Bustamante J, Ferry T, Chidiac C, Ader F, Emerging infectious diseases 2016 06 22 6 1124-1126
- Anti-IFN-γ autoantibodies are strongly associated with HLA-DR*15:02/16:02 and HLA-DQ*05:01/05:02 across Southeast Asia.
  Ku CL, Lin CH, Chang SW, Chu CC, Chan JF, Kong XF, Lee CH, Rosen EA, Ding JY, Lee WI, Bustamante J, Witte T, Shih HP, Kuo CY, Chetchotisakd P, Kiertiburanakul S, Suputtamongkol Y, Yuen KY, Casanova JL, Holland SM, Doffinger R, Browne SK, Chi CY, The Journal of allergy and clinical immunology 2016 Mar 137 3 945-8.e8
- The human gene damage index as a gene-level approach to prioritizing exome variants.
  Itan Y, Shang L, Boisson B, Patin E, Bolze A, Moncada-Vélez M, Scott E, Ciancanelli MJ, Lafaille FG, Markle JG, Martinez-Barricarte R, de Jong SJ, Kong XF, Nitschke P, Belkadi A, Bustamante J, Puel A, Boisson-Dupuis S, Stenson PD, Gleeson JG, Cooper DN, Quintana-Murci L, Claverie JM, Zhang SY, Abel L, Casanova JL Proceedings of the National Academy of Sciences of the United States of America 2015 Oct
- Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome.
  Kreins AY, Ciancanelli MJ, Okada S, Kong XF, Ramírez-Alejo N, Kilic SS, El Baghdadi J, Nonoyama S, Mahdaviani SA, Ailal F, Bousfiha A, Mansouri D, Nievas E, Ma CS, Rao G, Bernasconi A, Sun Kuehn H, Niemela J, Stoddard J, Deveau P, Cobat A, El Azbaoui S, Sabri A, Lim CK, Sundin M, Avery DT, Halwani R, Grant AV, Boisson B, Bogunovic D, Itan Y, Moncada-Velez M, Martinez-Barricarte R, Migaud M, Deswarte C, Alsina L, Kotlarz D, Klein C, Muller-Fleckenstein I, Fleckenstein B, Cormier-Daire V, Rose-John S, Picard C, Hammarstrom L, Puel A, Al-Muhsen S, Abel L, Chaussabel D, Rosenzweig SD, Minegishi Y, Tangye SG, Bustamante J, Casanova JL, Boisson-Dupuis S, The Journal of experimental medicine 2015 Sep 212 10 1641-62
- Inherent lipid metabolic dysfunction in glycogen storage disease IIIa.
  Li XH, Gong QM, Ling Y, Huang C, Yu DM, Gu LL, Liao XW, Zhang DH, Hu XQ, Han Y, Kong XF, Zhang XX Biochemical and biophysical research communications 2014 Dec 455 1-2 90-7
- Mycobacterium simiae infection in two unrelated patients with different forms of inherited IFN-γR2 deficiency.
  Martínez-Barricarte R, Megged O, Stepensky P, Casimir P, Moncada-Velez M, Averbuch D, Assous MV, Abuzaitoun O, Kong XF, Pedergnana V, Deswarte C, Migaud M, Rose-John S, Itan Y, Boisson B, Belkadi A, Conti F, Abel L, Vogt G, Boisson-Dupuis S, Casanova JL, Bustamante J, Journal of clinical immunology 2014 Nov 34 8 904-9
- Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis.
  Mizoguchi Y, Tsumura M, Okada S, Hirata O, Minegishi S, Imai K, Hyakuna N, Muramatsu H, Kojima S, Ozaki Y, Imai T, Takeda S, Okazaki T, Ito T, Yasunaga S, Takihara Y, Bryant VL, Kong XF, Cypowyj S, Boisson-Dupuis S, Puel A, Casanova JL, Morio T, Kobayashi M Journal of leukocyte biology 2013 Dec
- Partial IFN-γR2 deficiency is due to protein misfolding and can be rescued by inhibitors of glycosylation.
  Moncada-Vélez M, Martinez-Barricarte R, Bogunovic D, Kong XF, Blancas-Galicia L, Tirpan C, Aksu G, Vincent QB, Boisson B, Itan Y, Ramírez-Alejo N, Okada S, Kreins AY, Bryant VL, Franco JL, Migaud M, Espinosa-Padilla S, Yamazaki-Nakashimada M, Espinosa-Rosales F, Kutukculer N, Abel L, Bustamante J, Vogt G, Casanova JL, Boisson-Dupuis S, Blood 2013 Oct 122 14 2390-401
- Recurrent porphyria attacks in a Chinese patient with a heterozygous PBGD mutation.
  Kong XF, Han Y, Li XH, Gao DY, Zhang XX, Gong QM Gene 2013 Jul 524 2 401-2
- Haploinsufficiency at the human IFNGR2 locus contributes to mycobacterial disease.
  Kong XF, Vogt G, Itan Y, Macura-Biegun A, Szaflarska A, Kowalczyk D, Chapgier A, Abhyankar A, Furthner D, Djambas Khayat C, Okada S, Bryant VL, Bogunovic D, Kreins A, Moncada-Vélez M, Migaud M, Al-Ajaji S, Al-Muhsen S, Holland SM, Abel L, Picard C, Chaussabel D, Bustamante J, Casanova JL, Boisson-Dupuis S, Human molecular genetics 2013 Feb 22 4 769-81
- A novel homozygous p.R1105X mutation of the AP4E1 gene in twins with hereditary spastic paraplegia and mycobacterial disease.
  Kong XF, Bousfiha A, Rouissi A, Itan Y, Abhyankar A, Bryant V, Okada S, Ailal F, Bustamante J, Casanova JL, Hirst J, Boisson-Dupuis S, PloS one 2013 8 3 e58286
- Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency.
  Bogunovic D, Byun M, Durfee LA, Abhyankar A, Sanal O, Mansouri D, Salem S, Radovanovic I, Grant AV, Adimi P, Mansouri N, Okada S, Bryant VL, Kong XF, Kreins A, Velez MM, Boisson B, Khalilzadeh S, Ozcelik U, Darazam IA, Schoggins JW, Rice CM, Al-Muhsen S, Behr M, Vogt G, Puel A, Bustamante J, Gros P, Huibregtse JM, Abel L, Boisson-Dupuis S, Casanova JL Science (New York, N.Y.) 2012 Sep 337 6102 1684-8
- Dominant-negative STAT1 SH2 domain mutations in unrelated patients with Mendelian susceptibility to mycobacterial disease.
  Tsumura M, Okada S, Sakai H, Yasunaga S, Ohtsubo M, Murata T, Obata H, Yasumi T, Kong XF, Abhyankar A, Heike T, Nakahata T, Nishikomori R, Al-Muhsen S, Boisson-Dupuis S, Casanova JL, Alzahrani M, Shehri MA, Elghazali G, Takihara Y, Kobayashi M, Human mutation 2012 Sep 33 9 1377-87
- Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes.
  Boisson-Dupuis S, Kong XF, Okada S, Cypowyj S, Puel A, Abel L, Casanova JL, Current opinion in immunology 2012 Aug 24 4 364-78
- Mendelian susceptibility to mycobacterial disease in egyptian children.
  Galal N, Boutros J, Marsafy A, Kong XF, Feinberg J, Casanova JL, Boisson-Dupuis S, Bustamante J, Mediterranean journal of hematology and infectious diseases 2012 4 1 e2012033
- Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis.
  Liu L, Okada S, Kong XF, Kreins AY, Cypowyj S, Abhyankar A, Toubiana J, Itan Y, Audry M, Nitschke P, Masson C, Toth B, Flatot J, Migaud M, Chrabieh M, Kochetkov T, Bolze A, Borghesi A, Toulon A, Hiller J, Eyerich S, Eyerich K, Gulácsy V, Chernyshova L, Chernyshov V, Bondarenko A, Grimaldo RM, Blancas-Galicia L, Beas IM, Roesler J, Magdorf K, Engelhard D, Thumerelle C, Burgel PR, Hoernes M, Drexel B, Seger R, Kusuma T, Jansson AF, Sawalle-Belohradsky J, Belohradsky B, Jouanguy E, Bustamante J, Bué M, Karin N, Wildbaum G, Bodemer C, Lortholary O, Fischer A, Blanche S, Al-Muhsen S, Reichenbach J, Kobayashi M, Rosales FE, Lozano CT, Kilic SS, Oleastro M, Etzioni A, Traidl-Hoffmann C, Renner ED, Abel L, Picard C, Maródi L, Boisson-Dupuis S, Puel A, Casanova JL, The Journal of experimental medicine 2011 Aug 208 8 1635-48
- IRF8 mutations and human dendritic-cell immunodeficiency.
  Hambleton S, Salem S, Bustamante J, Bigley V, Boisson-Dupuis S, Azevedo J, Fortin A, Haniffa M, Ceron-Gutierrez L, Bacon CM, Menon G, Trouillet C, McDonald D, Carey P, Ginhoux F, Alsina L, Zumwalt TJ, Kong XF, Kumararatne D, Butler K, Hubeau M, Feinberg J, Al-Muhsen S, Cant A, Abel L, Chaussabel D, Doffinger R, Talesnik E, Grumach A, Duarte A, Abarca K, Moraes-Vasconcelos D, Burk D, Berghuis A, Geissmann F, Collin M, Casanova JL, Gros P, The New England journal of medicine 2011 Jul 365 2 127-38
- Clinical and molecular characterization of Wilson's disease in China: identification of 14 novel mutations.
  Li XH, Lu Y, Ling Y, Fu QC, Xu J, Zang GQ, Zhou F, De-Min Y, Han Y, Zhang DH, Gong QM, Lu ZM, Kong XF, Wang JS, Zhang XX BMC medical genetics 2011 12 6
- A novel form of human STAT1 deficiency impairing early but not late responses to interferons.
  Kong XF, Ciancanelli M, Al-Hajjar S, Alsina L, Zumwalt T, Bustamante J, Feinberg J, Audry M, Prando C, Bryant V, Kreins A, Bogunovic D, Halwani R, Zhang XX, Abel L, Chaussabel D, Al-Muhsen S, Casanova JL, Boisson-Dupuis S, Blood 2010 Dec 116 26 5895-906
- Revisiting human IL-12Rß1 deficiency: a survey of 141 patients from 30 countries.
  de Beaucoudrey L, Samarina A, Bustamante J, Cobat A, Boisson-Dupuis S, Feinberg J, Al-Muhsen S, Jannière L, Rose Y, de Suremain M, Kong XF, Filipe-Santos O, Chapgier A, Picard C, Fischer A, Dogu F, Ikinciogullari A, Tanir G, Al-Hajjar S, Al-Jumaah S, Frayha HH, AlSum Z, Al-Ajaji S, Alangari A, Al-Ghonaium A, Adimi P, Mansouri D, Ben-Mustapha I, Yancoski J, Garty BZ, Rodriguez-Gallego C, Caragol I, Kutukculer N, Kumararatne DS, Patel S, Doffinger R, Exley A, Jeppsson O, Reichenbach J, Nadal D, Boyko Y, Pietrucha B, Anderson S, Levin M, Schandené L, Schepers K, Efira A, Mascart F, Matsuoka M, Sakai T, Siegrist CA, Frecerova K, Blüetters-Sawatzki R, Bernhöft J, Freihorst J, Baumann U, Richter D, Haerynck F, De Baets F, Novelli V, Lammas D, Vermylen C, Tuerlinckx D, Nieuwhof C, Pac M, Haas WH, Müller-Fleckenstein I, Fleckenstein B, Levy J, Raj R, Cohen AC, Lewis DB, Holland SM, Yang KD, Wang X, Wang X, Jiang L, Yang X, Zhu C, Xie Y, Lee PPW, Chan KW, Chen TX, Castro G, Natera I, Codoceo A, King A, Bezrodnik L, Di Giovani D, Gaillard MI, de Moraes-Vasconcelos D, Grumach AS, da Silva Duarte AJ, Aldana R, Espinosa-Rosales FJ, Bejaoui M, Bousfiha AA, Baghdadi JE, Özbek N, Aksu G, Keser M, Somer A, Hatipoglu N, Aydogmus Ç, Asilsoy S, Camcioglu Y, Gülle S, Ozgur TT, Ozen M, Oleastro M, Bernasconi A, Mamishi S, Parvaneh N, Rosenzweig S, Barbouche R, Pedraza S, Lau YL, Ehlayel MS, Fieschi C, Abel L, Sanal O, Casanova JL, Medicine 2010 Nov 89 6 381-402
- A novel form of cell type-specific partial IFN-gammaR1 deficiency caused by a germ line mutation of the IFNGR1 initiation codon.
  Kong XF, Vogt G, Chapgier A, Lamaze C, Bustamante J, Prando C, Fortin A, Puel A, Feinberg J, Zhang XX, Gonnord P, Pihkala-Saarinen UM, Arola M, Moilanen P, Abel L, Korppi M, Boisson-Dupuis S, Casanova JL, Human molecular genetics 2010 Feb 19 3 434-44
- A partial form of recessive STAT1 deficiency in humans.
  Chapgier A, Kong XF, Boisson-Dupuis S, Jouanguy E, Averbuch D, Feinberg J, Zhang SY, Bustamante J, Vogt G, Lejeune J, Mayola E, de Beaucoudrey L, Abel L, Engelhard D, Casanova JL, The Journal of clinical investigation 2009 Jun 119 6 1502-14
- Identification of a ferrochelatase mutation in a Chinese family with erythropoietic protoporphyria.
  Kong XF, Ye J, Gao DY, Gong QM, Zhang DH, Lu ZM, Lu YM, Zhang XX, Journal of hepatology 2008 Feb 48 2 375-9
- No mutation was found in the alpha-subunit of the mitochondrial tri-functional protein in one patient with severe acute fatty liver of pregnancy and her relatives.
  Kong XF, Zhang XX, Yu YY, Shi Q, La DD, Zhu-Ge CD, Deng L, Gong QM, Shen BY, Peng CH, Li HW Journal of gastroenterology and hepatology 2007 Dec 22 12 2107-11
- MxA induction may predict sustained virologic responses of chronic hepatitis B patients with IFN-alpha treatment.
  Kong XF, Zhang XX, Gong QM, Gao J, Zhang SY, Wang L, Xu J, Han Y, Jin GD, Jiang JH, Zhang DH, Lu ZM, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007 Sep 27 9 809-18

Research

Celiac disease
Human genetics
Immunology
Inflammatory bowel disease
Rare digestive and liver diseases

Clinical Focus

Celiac Disease
Common variable immunodeficiency
Down syndrome
Inflammatory Bowel Disease
Rare liver disease

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