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At UT Southwestern, our doctors use a wide range of medications, usually eye drops, to treat glaucoma. Medications can reduce pressure within the eye, either by increasing fluid drainage from the eye or reducing the amount of fluid the eye produces.
It is important to use medicines as directed to maintain proper eye pressure because untreated glaucoma can lead to blindness. However, because many of these side effects can lead to serious health complications, patients should call their doctors immediately if they begin to notice any symptoms listed below.
Drugs to treat glaucoma and some potential side effects of each include:
Prostaglandin Analogs
These eye drops are the most often used for treating glaucoma. Brand names include Xalatan®, Travatan® Z, Lumigan®, and Zioptan™, and these drugs increase fluid drainage. Side effects can include:
- Blurry vision
- Change in eye color
- Discolored skin around the eye
- Eye discomfort, such as stinging, redness, itching, or burning
- Flu-like symptoms such as fatigue, fever, and muscle aches
Beta Blockers
The second most commonly prescribed eye drops for glaucoma, beta blockers reduce fluid production in the eye. Brand names include Timoptic®, Betoptic®, and Betagan®, and possible side effects include:
- Bradycardia (slow heart rate)
- Congestive heart failure
- Chronic obstructive pulmonary disease (COPD)
- Difficulty sleeping (insomnia)
- Fatigue
- Irritability
- Impotence (erectile dysfunction)
- Low blood pressure
- Reduced ability to exercise
- Reduced HDL (good cholesterol)
- Reduced pulse
- Shortness of breath in people who have asthma or other lung conditions
Miotics
These medications, also known as cholinergics, increase fluid drainage from the eye. Brand names include Pilocarpine®. Side effects can include:
- Dim vision, particularly at night or in low-light environments
- Headache
- Nausea and vomiting
- Excessive salivation and tearing
- Sweating
Topical Carbonic Anhydrase Inhibitors
These eye drops reduce fluid production in the eye. Brand names include Trusopt® and Azopt®. Possible side effects include:
- Eye discomfort, such as stinging or burning
- Fatigue
- Kidney stones (rare)
- Paresthesia (unusual sensation such as prickling or tingling)
- Skin rash around the eye
Selective Adrenergic Agents
Also known as alpha agonists, these eye drops both decrease fluid production and increase fluid drainage from the eye. Brand names include Alphagan® P, which can cause side effects such as:
- Chest tightness
- Cold extremities (hands and feet)
- Dry mouth and nose
- Eye discomfort, such as stinging or burning
- Fatigue and drowsiness
- Headache
- Muscular pain
- Nausea
- Pulmonary edema
- Subdural hematoma (accumulated blood between the covering of the brain (dura) and its surface)
Combination Products
Currently, there are three combination products approved for the treatment of glaucoma. They include Cosopt® (Timoptic®/Trusopt®), Combigan® (Timoptic®/Alphagan®), and Simbrinza® (Azopt®/Alphagan®). Side effects are similar to those for the individual agents described above.