- Fellowship - National Institutes of Health (2003-2006), Infectious Diseases
- Residency - Baylor College of Medicine (2002-2003), Internal Medicine
- Residency - Baylor College of Medicine (1999-2002), Internal Medicine
- Medical School - Baylor College of Medicine (1995-1999)
- University - Johns Hopkins Bloomberg School of Public Health (1991-1995)

David Greenberg, M.D.
- Distinguished Teaching Professor
- Internal Medicine - Infectious Diseases and Geographic Medicine
- Transplant Infectious Diseases
- Antibiotic-Resistant Infections
Biography
David Greenberg, M.D., is an Associate Professor and Distinguished Teaching Professor in the Department of Internal Medicineat UT Southwestern Medical Center. He specializes in transplant infectious diseases, antibiotic-resistant infections, and immunocompromised patients.
Dr. Greenberg earned his medical degree and completed a residency in internal medicine at Baylor College of Medicine. He received advanced training in infectious diseases through a fellowship at the National Institutes of Health’s National Institute of Allergy and Infectious Diseases.
Certified by the American Board of Internal Medicine in infectious diseases, he joined the UT Southwestern faculty in 2010.
Dr. Greenberg’s research focuses on the development of novel antibacterial therapeutics for multidrug-resistant bacteria. His lab uses peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) to block mRNA and prevent translation of target genes. He has received significant grant support for his research, and he holds several patents related to the technology involved.
At UT Southwestern, Dr. Greenberg is the Director of Microbial Genomics in the Infectious Diseases Division and focuses on utilizing whole-genome sequencing to predict antibiotic resistance. In addition, he co-chairs UTSW’s Biorepository Stewardship Committee and is the Faculty Advisor for the Infectious Diseases Interest Group. He directs several courses for medical students, including one titled Emerging Infectious Diseases and the Microbiome.
Dr. Greenberg has received numerous teaching awards from UT Southwestern. In 2014, he was awarded the Regents’ Outstanding Teacher Award, and in 2020 he was inducted into the Kenneth Shine Academy, the premier health science education academy in the University of Texas system.
He has published countless academic articles and delivered numerous invited lectures. He is a member of the American Society for Microbiology and serves on the Infectious Diseases Society of America’s Antimicrobial Resistance Committee.
Education & Training
Professional Associations & Affiliations
- American Society for Microbiology
- Infectious Diseases Society of America
Honors & Awards
- Induction into the Kenneth Shine Academy 2020, The University of Texas System
- Induction into Alpha Omega Alpha Society 2018, UT Southwestern
- Organisms and Host Course, MVP Award 2015-2018, UT Southwestern
- Outstanding Teacher Award, MS2 Class 2011-2016, UT Southwestern
- Faculty Marshall Medical School Graduation , 2013, 2015, 2016, 2019, UT Southwestern
- Induction into Southwestern Association of Teachers (SWAT) 2014, UT Southwestern
- Second Place: Innovation in Health Science Education Award 2014, University of Texas Academy of Health Science Education
- Regents' Outstanding Teacher Award 2014, The University of Texas System
- Excellence in Education Award 2011-2013, UT Southwestern
- Merit Award 2009, National Institute of Allergy and Infectious Diseases Award
- Director's Award 2007, National Institutes of Health
- Fellows Award for Research Excellence 2006, National Institutes of Health
- Special Citation for Fellow-in-Training 2005, Infectious Diseases Society of America
Books & Publications
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Books
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Stenotrophomonas maltophilia and Burkholderia cepacia. Principles and Practices of Infectious Diseases. Bennett J, Dolin R, Blaser M (Eds.)
Greenberg DE (2019), Elsevier
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Stenotrophomonas maltophilia and Burkholderia cepacia. Principles and Practices of Infectious Diseases. Bennett J, Dolin R, Blaser M (Eds.)
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Publications
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Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo.
Sully EK, Geller BL, Li L, Moody CM, Bailey SM, Moore AL, Wong M, Nordmann P, Daly SM, Sturge CR, Greenberg DE The Journal of antimicrobial chemotherapy 2016 Dec -
Burkholderia cenocepacia J2315 escapes to the cytosol and actively subverts autophagy in human macrophages.
Al-Khodor S, Marshall-Batty K, Nair V, Ding L, Greenberg DE, Fraser ID Cellular microbiology 2013 Oct -
Inhibition of Pseudomonas aeruginosa by Peptide-conjugated Phosphorodiamidate Morpholino Oligomers.
Howard JJ, Sturge CR, Moustafa DA, Daly SM, Marshall-Batty KR, Felder CF, Zamora D, Yabe-Gill M, Labandeira-Rey M, Bailey SM, Wong M, Goldberg JB, Geller BL, Greenberg DE Antimicrobial agents and chemotherapy 2017 Jan -
Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy.
Ayhan DH, Tamer YT, Akbar M, Bailey SM, Wong M, Daly SM, Greenberg DE, Toprak E PLoS biology 2016 Sep 14 9 e1002552 -
Primary osteomyelitis caused by hypervirulent Klebsiella pneumoniae.
Prokesch BC, TeKippe M, Kim J, Raj P, TeKippe EM, Greenberg DE The Lancet. Infectious diseases 2016 Jul -
Gene-silencing antisense oligomers inhibit acinetobacter growth in vitro and in vivo.
Geller BL, Marshall-Batty K, Schnell FJ, McKnight MM, Iversen PL, Greenberg DE The Journal of infectious diseases 2013 Nov 208 10 1553-60 -
Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis.
Sampaio EP, Hsu AP, Pechacek J, Bax HI, Dias DL, Paulson ML, Chandrasekaran P, Rosen LB, Carvalho DS, Ding L, Vinh DC, Browne SK, Datta S, Milner JD, Kuhns DB, Long Priel DA, Sadat MA, Shiloh M, De Marco B, Alvares M, Gillman JW, Ramarathnam V, de la Morena M, Bezrodnik L, Moreira I, Uzel G, Johnson D, Spalding C, Zerbe CS, Wiley H, Greenberg DE, Hoover SE, Rosenzweig SD, Galgiani JN, Holland SM The Journal of allergy and clinical immunology 2013 Mar -
Innate immunity against Granulibacter bethesdensis, an emerging gram-negative bacterial pathogen.
Zarember KA, Marshall-Batty KR, Cruz AR, Chu J, Fenster ME, Shoffner AR, Rogge LS, Whitney AR, Czapiga M, Song HH, Shaw PA, Nagashima K, Malech HL, DeLeo FR, Holland SM, Gallin JI, Greenberg DE Infection and immunity 2012 Mar 80 3 975-81 -
Recurrent Granulibacter bethesdensis infections and chronic granulomatous disease.
Greenberg DE, Shoffner AR, Zelazny AM, Fenster ME, Zarember KA, Stock F, Ding L, Marshall-Batty KR, Wasserman RL, Welch DF, Kanakabandi K, Sturdevant DE, Virtaneva K, Porcella SF, Murray PR, Malech HL, Holland SM Emerging infectious diseases 2010 Sep 16 9 1341-8 -
Granulibacter bethesdensis gen. nov., sp. nov., a distinctive pathogenic acetic acid bacterium in the family Acetobacteraceae.
Greenberg DE, Porcella SF, Stock F, Wong A, Conville PS, Murray PR, Holland SM, Zelazny AM International journal of systematic and evolutionary microbiology 2006 Nov 56 Pt 11 2609-16 -
A novel bacterium associated with lymphadenitis in a patient with chronic granulomatous disease.
Greenberg DE, Ding L, Zelazny AM, Stock F, Wong A, Anderson VL, Miller G, Kleiner DE, Tenorio AR, Brinster L, Dorward DW, Murray PR, Holland SM PLoS pathogens 2006 Apr 2 4 e28 -
Markers of inflammation in bacterial diarrhea among travelers, with a focus on enteroaggregative Escherichia coli pathogenicity.
Greenberg DE, Jiang ZD, Steffen R, Verenker MP, DuPont HL The Journal of infectious diseases 2002 Apr 185 7 944-9 -
Peptide-conjugated phosphorodiamidate morpholino oligomers: a new strategy for tackling antibiotic resistance.
Geller BL, Greenberg DE Therapeutic delivery 2014 Mar 5 3 243-5 -
Methylotroph Infections and Chronic Granulomatous Disease.
Falcone EL, Petts JR, Fasano MB, Ford B, Nauseef WM, Neves JF, Simões MJ, Tierce ML, de la Morena MT, Greenberg DE, Zerbe CS, Zelazny AM, Holland SM Emerging infectious diseases 2016 Mar 22 3 404-9 -
Microbiological culture methods for pediatric musculoskeletal infection: a guideline for optimal use.
Section J, Gibbons SD, Barton T, Greenberg DE, Jo CH, Copley LA The Journal of bone and joint surgery. American volume 2015 Mar 97 6 441-9 -
Acinetobacter infections and outcomes at an academic medical center: a disease of long-term care.
Townsend J, Park AN, Gander R, Orr K, Arocha D, Zhang S, Greenberg DE Open forum infectious diseases 2015 Jan 2 1 ofv023 -
Simultaneous Host-Pathogen transcriptome analysis during Granulibacter bethesdensis infection of normal and chronic granulomatous disease neutrophils.
Greenberg DE, Sturdevant DE, Marshall-Batty KR, Chu J, Pettinato AM, Virtaneva K, Lane J, Geller BL, Porcella SF, Gallin JI, Holland SM, Zarember KA Infection and immunity 2015 Aug -
Pulmonary nontuberculous mycobacterial disease: prospective study of a distinct preexisting syndrome.
Kim RD, Greenberg DE, Ehrmantraut ME, Guide SV, Ding L, Shea Y, Brown MR, Chernick M, Steagall WK, Glasgow CG, Lin J, Jolley C, Sorbara L, Raffeld M, Hill S, Avila N, Sachdev V, Barnhart LA, Anderson VL, Claypool R, Hilligoss DM, Garofalo M, Fitzgerald A, Anaya-O'Brien S, Darnell D, DeCastro R, Menning HM, Ricklefs SM, Porcella SF, Olivier KN, Moss J, Holland SM American journal of respiratory and critical care medicine 2008 Nov 178 10 1066-74 -
Antisense phosphorodiamidate morpholino oligomers targeted to an essential gene inhibit Burkholderia cepacia complex.
Greenberg DE, Marshall-Batty KR, Brinster LR, Zarember KA, Shaw PA, Mellbye BL, Iversen PL, Holland SM, Geller BL The Journal of infectious diseases 2010 Jun 201 12 1822-30 -
Immune function in young children with previous pulmonary or miliary/meningeal tuberculosis and impact of BCG vaccination.
Sterling TR, Martire T, de Almeida AS, Ding L, Greenberg DE, Moreira LA, Elloumi H, Torres AP, Sant'Anna CC, Calazans E, Paraguassu G, Gebretsadik T, Shintani A, Miller K, Kritski A, Lapa e Silva JR, Holland SM Pediatrics 2007 Oct 120 4 e912-21 -
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis.
Greenberg DE, Porcella SF, Zelazny AM, Virtaneva K, Sturdevant DE, Kupko JJ, Barbian KD, Babar A, Dorward DW, Holland SM Journal of bacteriology 2007 Dec 189 23 8727-36 -
Combating resistance while maintaining innovation: the future of antimicrobial stewardship.
Vickers RJ, Bassetti M, Clancy CJ, Garey KW, Greenberg DE, Nguyen MH, Roblin D, Tillotson GS, Wilcox MH, Future microbiology 2019 Sep -
Identification and Whole Genome Sequencing of the First Case of Kosakonia radicincitans Causing a Human Bloodstream Infection.
Bhatti MD, Kalia A, Sahasrabhojane P, Kim J, Greenberg DE, Shelburne SA Frontiers in microbiology 2017 8 62 -
Remote acoustic sensing as a safety mechanism during exposure of metal implants to alternating magnetic fields.
Cheng B, Chatzinoff Y, Szczepanski D, Bing C, Shaikh S, Wyman O, Perry CE, Richardson JA, Burns DK, Evers BM, Greenberg DE, Chopra R PloS one 2018 13 5 e0197380 -
Morpholino oligomers tested in vitro, in biofilm and in vivo against multidrug-resistant Klebsiella pneumoniae.
Geller BL, Li L, Martinez F, Sully E, Sturge CR, Daly SM, Pybus C, Greenberg DE The Journal of antimicrobial chemotherapy 2018 Mar -
Whole genome sequencing of Staphylococcus epidermidis bloodstream isolates from a prospective clinical trial reveals that complicated bacteremia is caused by a limited number of closely related sequence types.
Shelburne SA, Dib RW, Endres BT, Reitzel R, Li X, Kalia A, Sahasrabhojane P, Chaftari AM, Hachem R, Vargas-Cruz NS, Jiang Y, Garey K, Fowler VG, Holland TL, Gu J, Miller W, Sakurai A, Arias CA, Aitken SL, Greenberg DE, Kim J, Flores AR, Raad I, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2019 Oct -
Draft genome sequence determination for cystic fibrosis and chronic granulomatous disease Burkholderia multivorans isolates.
Varga JJ, Losada L, Zelazny AM, Brinkac L, Harkins D, Radune D, Hostetler J, Sampaio EP, Ronning CM, Nierman WC, Greenberg DE, Holland SM, Goldberg JB Journal of bacteriology 2012 Nov 194 22 6356-7 -
The use of automated data extraction tools to develop a solid organ transplant registry: Proof of concept study of bloodstream infections.
La Hoz RM, Liu T, Xie D, Adams-Huet B, Willett DL, Haley RW, Greenberg DE, The Journal of infection 2020 Oct -
Immune Function in Young Children with Prior Pulmonary or Miliary/Meningeal Tuberculosis and Impact of BCG Vaccination.
Sterling TR, Nartire T, Silva de Almeida A, Ding L, Greenberg DE, Noreira LA, Elloumi H, Torres A, Sant?Anna CC, Calazans E, Paraguassu G, Gebretsadik T, Shintani A, Miller K, Kritski A, Lapa e Silva JR and Holland SM. Pediatrics 2007 120 4 e912-e921 -
MCR-1 Inhibition with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Sensitivity to Polymyxin in Escherichia coli.
Daly SM, Sturge CR, Felder-Scott CF, Geller BL, Greenberg DE mBio 2017 Nov 8 6 -
17ß-estradiol dysregulates innate immune responses to Pseudomonas aeruginosa respiratory infection and is modulated by estrogen receptor antagonism.
Abid S, Xie S, Bose M, Shaul PW, Terada LS, Brody SL, Thomas PJ, Katzenellenbogen JA, Kim SH, Greenberg DE, Jain R Infection and immunity 2017 Aug -
Employing high-frequency alternating magnetic fields for the non-invasive treatment of prosthetic joint infections.
Chopra R, Shaikh S, Chatzinoff Y, Munaweera I, Cheng B, Daly SM, Xi Y, Bing C, Burns D, Greenberg DE Scientific reports 2017 Aug 7 1 7520 -
Antibiotic-Induced Depletion of Anti-Inflammatory Clostridia is Associated with the Development of GVHD in Pediatric Stem Cell Transplant Patients.
Simms-Waldrip TR, Sunkersett G, Coughlin LA, Savani MR, Arana C, Kim J, Kim M, Zhan X, Greenberg DE, Xie Y, Davies SM, Koh AY Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2017 Feb -
Antimicrobial Activity of Ibuprofen Against Cystic Fibrosis Associated Gram-Negative Pathogens.
Shah PN, Marshall-Batty KR, Smolen JA, Tagaev JA, Chen Q, Rodesney CA, Le HH, Gordon VD, Greenberg DE, Cannon CL Antimicrobial agents and chemotherapy 2018 Jan -
Fabrication and Microscopic and Spectroscopic Characterization of Cytocompatible Self-Assembling Antimicrobial Nanofibers.
Xu D, Chen W, Tobin-Miyaji YJ, Sturge CR, Yang S, Elmore B, Singh A, Pybus C, Greenberg DE, Sellati TJ, Qiang W, Dong H ACS infectious diseases 2018 Jul -
Temperature-sensitive liposomal ciprofloxacin for the treatment of biofilm on infected metal implants using alternating magnetic fields.
Munaweera I, Shaikh S, Maples D, Nigatu AS, Sethuraman SN, Ranjan A, Greenberg DE, Chopra R International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2018 Mar 34 2 189-200 -
VAMPr: VAriant Mapping and Prediction of antibiotic resistance via explainable features and machine learning.
Kim J, Greenberg DE, Pifer R, Jiang S, Xiao G, Shelburne SA, Koh A, Xie Y, Zhan X, PLoS computational biology 2020 Jan 16 1 e1007511 -
Optimizing Breast Pocket Irrigation: The Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Era.
Culbertson EJ, Felder-Scott C, Deva AK, Greenberg DE, Adams WP, Aesthetic surgery journal 2019 Sep -
Acidomonas methanolica-associated necrotizing lymphadenitis in a patient with chronic granulomatous disease.
Chase JM, Holland SM, Greenberg DE, Marshall-Batty K, Zelazny AM, Church JA Journal of clinical immunology 2012 Dec 32 6 1193-6 -
AcrAB-TolC Inhibition by Peptide-conjugated Phosphorodiamidate Morpholino Oligomers Restores Antibiotic Activity in vitro and in vivo.
Sturge CR, Felder-Scott CF, Pifer R, Pybus C, Jain R, Geller B, Greenberg D, ACS infectious diseases 2019 May -
Antisense Inhibitors Retain Activity in Pulmonary Models of Burkholderia Infection.
Daly SM, Sturge CR, Marshall-Batty KR, Felder-Scott CF, Jain R, Geller BL, Greenberg DE ACS infectious diseases 2018 Mar -
Discovery and characterization of New Delhi metallo-ß-lactamase-1 inhibitor peptides that potentiate meropenem-dependent killing of carbapenemase-producing Enterobacteriaceae.
Kazi MI, Perry BW, Card DC, Schargel RD, Ali HB, Obuekwe VC, Sapkota M, Kang KN, Pellegrino MW, Greenberg DE, Castoe TA, Boll JM, The Journal of antimicrobial chemotherapy 2020 Oct 75 10 2843-2851 -
Host-microbe interaction systems biology: lifecycle transcriptomics and comparative genomics.
Sturdevant DE, Virtaneva K, Martens C, Bozinov D, Ogundare O, Castro N, Kanakabandi K, Beare PA, Omsland A, Ohmsland A, Carlson JH, Kennedy AD, Heinzen RA, Celli J, Greenberg DE, DeLeo FR, Porcella SF Future microbiology 2010 Feb 5 2 205-19 -
Cefiderocol Retains Antibiofilm Activity in Multidrug-Resistant Gram-Negative Pathogens.
Pybus CA, Felder-Scott C, Obuekwe V, Greenberg DE, Antimicrobial agents and chemotherapy 2021 Jan 65 2 -
Rate of occurrence and pathogenic effect of enteroaggregative Escherichia coli virulence factors in international travelers.
Jiang ZD, Greenberg D, Nataro JP, Steffen R, DuPont HL, Journal of clinical microbiology 2002 Nov 40 11 4185-90 -
Serologic reactivity to the emerging pathogen Granulibacter bethesdensis.
Greenberg DE, Shoffner AR, Marshall-Batty KR, Arora K, Zhao M, Martin R, Ding L, Hammer CH, Shaw PA, Kuhns DB, Malech HL, Gallin JI, Zarember KA, Holland SM The Journal of infectious diseases 2012 Sep 206 6 943-51 -
Hemobilia in childhood.
Läckgren G, Lörelius LE, Olsen L, Wassén C, Journal of pediatric surgery 1988 Feb 23 2 105-8 -
A 60-year-old man with necrotic skin lesions after heart transplantation.
Prokesch BC, Cavuoti D, Le JB, Greenberg DE American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014 Nov 14 11 2664-6 -
Recurrent Burkholderia infection in patients with chronic granulomatous disease: 11-year experience at a large referral center.
Greenberg DE, Goldberg JB, Stock F, Murray PR, Holland SM, Lipuma JJ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009 Jun 48 11 1577-9 -
from sputum of patients with cystic fibrosis demonstrates a high rate of susceptibility to ceftazidime-avibactam.
Atkin SD, Abid S, Foster M, Bose M, Keller A, Hollaway R, Sader HS, Greenberg DE, Finklea JD, Castanheira M, Jain R Infection and drug resistance 2018 11 1499-1510
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Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo.
Research
- Antibiotic Resistance
- Antimicrobial Development
- Biofilm-Related Infections
- Gram-Negative Bacterial Infections
- Infections in Immunocompromised Hosts
Clinical Focus
- Transplant Infectious Diseases
- Antibiotic-Resistant Infections
- Immunocompromised Hosts
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William P. Clements Jr. University Hospital
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