- Fellowship - Kings College School of Medicine (1973-1974), Gastroenterology & Liver Diseases
- Residency - New York Presbyterian Hospital (1971-1973), Internal Medicine
- Internship - New York Presbyterian Hospital (1967-1968), Medicine
- Medical School - Columbia University College of Physicians and Surgeons (1963-1967)
William Lee, M.D.
- Meredith Mosle Chair in Liver Disease in Honor of Dr. William M. Lee
- Internal Medicine - Digestive & Liver Diseases
- Liver Disease
Dr. William Lee obtained his B.A. from Amherst College and received his medical degree from Columbia University College of Physicians and Surgeons. He did his training in Internal Medicine at the Presbyterian Hospital, New York City (Columbia-Presbyterian Medical Center) and served as Chief Resident on the Internal Medicine service. He was Honorary Registrar and Research Fellow to Dr. Roger Williams at the Liver Unit, Kings College Hospital, London from 1973-74. He has been on the faculty of Columbia University College of Physicians and Surgeons, and was Director of the Gastroenterology Division at the Medical University of South Carolina before coming to UT Southwestern in 1990.
Dr. Lee was included in D Magazine's Best Doctors list for 2018.
Meet Dr. Lee
Liver Disease Specialist
William M. Lee, M.D., is a renowned liver disease expert. He completed training at Columbia University College of Physicians and Surgeons, Columbia-Presbyterian Medical Center, and Kings College Hospital, London before embarking upon a career in academic medicine. He joined the UT Southwestern Medical Center faculty in 1990. Dr. Lee’s clinical research and patient care has focused on all forms of hepatitis—causes of inflammation and damage to the liver.
Dr. Lee became a hepatologist because the diseases of the liver are fascinating and represent unusual and important lessons in medicine.
After completing his medical degree from Columbia University College of Physicians and Surgeons, Dr. Lee completed his residency in Internal Medicine at Presbyterian Hospital, New York City, where he also served as Chief Resident. He then went on to serve as Honorary Registrar and Research Fellow to Dr. Roger Williams at the Liver Unit, Kings College Hospital, London from 1973-74. Dr. Lee joined the UT Southwestern faculty after more than two decades of experience as both a clinician and researcher.
Dr. Lee remains active in clinical research on viral hepatitis and drug-induced liver injury. He has been site investigator for four National Institute of Diabetes, Digestive and Kidney Diseases-sponsored Networks: the HALT-C Trial, the Acute Liver Failure Study Group, the Drug-Induced Liver Injury Network, and the Hepatitis B Research Network.
Dr. Lee says he chose UT Southwestern because it has tremendous research depths in the basic and clinical sciences.
He is a member of the American Association for the Study of Liver
Diseases (AASLD) and the American Gastroenterological Association, and
is a Fellow of the American College of Physicians and the American
College of Gastroenterology. In 2009, he gave the prestigious Leon
Schiff Memorial Lecture at the Annual AASLD meeting and in 2011 he
received the Award for Excellence for Outstanding Contributions in
Health/Sciences from the Dallas Historical Society. During the past
year, he has given numerous lectures on topics related to his research.
- American Gastroenterological Association
- American College of Gastroenterology
- American Association for the Study of Liver Disease (2015), Fellow
- American College of Physicians (1976), Fellow
- Alumni Gold Medal for Clinical Excellence from Columbia University Vagelos College of Physicians and Surgeons 2018
- Thomas A. and Shirley W. Roe Award, Journal of the South Carolina Medical Association
- Secretary-Treasurer, American Association for the Study of Liver Disease
- Alpha Omega Alpha, Medical Honor Society
- A. Blaine Brower Traveling Scholar, American College of Physicians
- Leon Schiff Lecturer, American Association for the Study of Liver Diseases 2008
- Hyman Zimmerman Memorial Lecturer, American Association for the Study of Liver Diseases 2013
- Distinguished Clinician Educator/Mentor Award, American Association for the Study of Liver Diseases 2014
Acute Liver Failure
Lee WM and Williams R.(Ed.) (1997), London, Cambridge University Press
- Acute Liver Failure
Relationship Between Metabolic Syndrome, Alanine Aminotransferase Levels, and Liver Disease Severity in a Multiethnic North American Cohort With Chronic Hepatitis B.
Khalili M, Shuhart MC, Lombardero M, Feld JJ, Kleiner DE, Chung RT, Terrault NA, Lisker-Melman M, Sanyal A, Lok AS Diabetes care 2018 Mar
Multiple Admissions for Acetaminophen (APAP) Overdose: APAP Frequent Fliers, a New Entity?
Yang E, Peng L, Lee WM Hepatology (Baltimore, Md.) 2018 Apr
miR-122 protects mice and human hepatocytes from acetaminophen toxicity by regulating CYP1A2 and CYP2E1 expression.
Chowdhary V, Teng KY, Thakral S, Zhang B, Lin CH, Wani N, Bruschweiler-Li L, Zhang X, James L, Yang D, Junge N, Brüschweiler R, Lee WM, Ghoshal K The American journal of pathology 2017 Sep
Safety, Tolerability and Pharmacokinetics of L-Ornithine Phenylacetate in Patients with Acute Liver Injury/Failure and Hyperammonemia.
Stravitz RT, Gottfried M, Durkalski V, Fontana RJ, Hanje AJ, Koch D, Hameed B, Ganger D, Subramanian RM, Bukofzer S, Ravis WR, Clasen K, Sherker A, Little L, Lee WM Hepatology (Baltimore, Md.) 2017 Oct
Viral Surveillance in Serum Samples From Patients With Acute Liver Failure By Metagenomic Next-Generation Sequencing.
Somasekar S, Lee D, Rule J, Naccache SN, Stone M, Busch MP, Sanders C, Lee WM, Chiu CY Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017 Oct 65 9 1477-1485
The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case-control study.
Karvellas CJ, Speiser JL, Tremblay M, Lee WM, Rose CF Annals of intensive care 2017 Oct 7 1 99
Psychosocial and behavioral factors in acetaminophen-related acute liver failure and liver injury.
Pezzia C, Sanders C, Welch S, Bowling A, Lee WM Journal of psychosomatic research 2017 Oct 101 51-57
Comment on: MARS System Effectively Replaces Hepatic Function in Severe Acute Liver Failure.
Karvellas CJ, Stravitz RT, Fontana RJ, Ganger D, Lee WM Annals of surgery 2017 Nov
Prevalence of Hepatitis B Antiviral Drug Resistance Variants in North American Patients with Chronic Hepatitis B Not Receiving Antiviral Treatment.
Lok AS, Ganova-Raeva L, Cloonan Y, Punkova L, Lin HS, Lee WM, Ghany MG Journal of viral hepatitis 2017 Jun
Bleeding Complications in Acute Liver Failure.
Stravitz RT, Ellerbe C, Durkalski V, Schilsky M, Fontana RJ, Peterseim C, Lee WM Hepatology (Baltimore, Md.) 2017 Dec
Clinical Features and Outcomes of Complementary and Alternative Medicine Induced Acute Liver Failure and Injury.
Hillman L, Gottfried M, Whitsett M, Rakela J, Schilsky M, Lee WM, Ganger D The American journal of gastroenterology 2016 Apr
Outcomes in Adults With Acute Liver Failure Between 1998 and 2013: An Observational Cohort Study.
Reuben A, Tillman H, Fontana RJ, Davern T, McGuire B, Stravitz RT, Durkalski V, Larson AM, Liou I, Fix O, Schilsky M, McCashland T, Hay JE, Murray N, Shaikh OS, Ganger D, Zaman A, Han SB, Chung RT, Smith A, Brown R, Crippin J, Harrison ME, Koch D, Munoz S, Reddy KR, Rossaro L, Satyanarayana R, Hassanein T, Hanje AJ, Olson J, Subramanian R, Karvellas C, Hameed B, Sherker AH, Robuck P, Lee WM Annals of internal medicine 2016 Apr
Evolution of hepatitis C virus NS5A region in breakthrough patients during pegylated interferon and ribavirin therapy*.
Yuan HJ, Jain M, Snow KK, Gale M, Lee WM Journal of viral hepatitis 2010 Mar 17 3 208-16
Autoimmune acute liver failure: proposed clinical and histological criteria.
Stravitz RT, Lefkowitch JH, Fontana RJ, Gershwin ME, Leung PS, Sterling RK, Manns MP, Norman GL, Lee WM Hepatology (Baltimore, Md.) 2011 Feb 53 2 517-26
What factors determine the severity of hepatitis A-related acute liver failure?
Ajmera V, Xia G, Vaughan G, Forbi JC, Ganova-Raeva LM, Khudyakov Y, Opio CK, Taylor R, Restrepo R, Munoz S, Fontana RJ, Lee WM Journal of viral hepatitis 2011 Jul 18 7 e167-74
Idiosyncratic Drug Induced Liver Injury is associated with Substantial Morbidity and Mortality within 6 months From Onset.
Fontana RJ, Hayashi PH, Gu J, Reddy KR, Barnhart H, Watkins PB, Serrano J, Lee WM, Chalasani N, Stolz A, Davern T, Talwakar JA Gastroenterology 2014 Mar
Circulating mannan-binding lectin, M-, L-, H-ficolin and collectin-liver-1 levels in patients with acute liver failure.
Laursen TL, Sandahl TD, Støy S, Schiødt FV, Lee WM, Vilstrup H, Thiel S, Grønbaek H Liver international : official journal of the International Association for the Study of the Liver 2014 Sep
Glycodeoxycholic Acid Levels as Prognostic Biomarker in Acetaminophen-induced Acute Liver Failure Patients.
Woolbright BL, McGill MR, Staggs VS, Winefield RD, Gholami P, Olyaee M, Sharpe MR, Curry SC, Lee WM, Jaeschke H Toxicological sciences : an official journal of the Society of Toxicology 2014 Sep
Detection of Ophthalmic Acid in Serum from Acetaminophen-Induced Acute Liver Failure Patients Is More Frequent in Non-Survivors.
Kaur G, Leslie EM, Tillman H, Lee WM, Swanlund DP, Karvellas CJ PloS one 2015 10 9 e0139299
Predicting outcome on admission and post-admission for acetaminophen-induced acute liver failure using classification and regression tree models.
Speiser JL, Lee WM, Karvellas CJ PloS one 2015 10 4 e0122929
HBV-specific and global T-cell dysfunction in chronic hepatitis B.
Park JJ, Wong DK, Wahed AS, Lee WM, Feld JJ, Terrault N, Khalili M, Sterling RK, Kowdley KV, Bzowej N, Lau DT, Kim WR, Smith C, Carithers RL, Torrey KW, Keith JW, Levine DL, Traum D, Ho S, Valiga ME, Johnson GS, Doo E, Lok AS, Chang KM Gastroenterology 2015 Dec
Acute Liver Injury and Acute Liver Failure from Mushroom Poisoning in North America.
Karvellas CJ, Tillman H, Leung AA, Lee WM, Schilsky ML, Hameed B, Todd Stravitz R, McGuire BM, Fix OK Liver international : official journal of the International Association for the Study of the Liver 2016 Feb
HBV-associated Acute Liver Failure after Immunosuppression and Risk of Death.
Karvellas CJ, Cardoso FS, Gottfried M, Reddy KR, Hanje AJ, Ganger D, Lee WM Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2016 Jun
An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients with Acute Liver Injury or Failure.
Roberts DW, Lee WM, Hinson JA, Bai S, Swearingen CJ, Stravitz RT, Reuben A, Letzig L, Simpson PM, Rule J, Fontana RJ, Ganger D, Reddy KR, Liou I, Fix O, James LP Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2016 Sep
Budd-Chiari Syndrome Causing Acute Liver Failure: A Multicenter Case Series.
Parekh J, Matei VM, Canas-Coto A, Friedman D, Lee WM Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2016 Sep
Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver Injury.
Randesi M, Levran O, Correa da Rosa J, Hankins J, Rule J, Kreek MJ, Lee WM Cellular and molecular gastroenterology and hepatology 2017 May 3 3 500-505
Medical Progress: Drug-Induced Hepatotoxicity
Lee WM N Engl J Med 2003 349 474-85
Evolution of the HALT-C Trial: pegylated interferon as maintenance therapy for chronic hepatitis C in previous interferon non-responders.
Lee WM, Dienstag JL, Lindsay KL, et al. Contr Clin Trials 2004 25 472-92.
Acute Liver Failure: Summary of a Workshop.
Lee WM, Squires RH Jr, Nyberg SL, Doo E, Hoofnagle JH Hepatology 2008 47 1401-15
Poor performance of hepatitis C antibody tests in hospital patients in Uganda.
Seremba E, Ocama P, Opio CK, Kagimu M, Thomas DL, Yuan HJ, Attar N, Lee WM Journal of medical virology 2010 Aug 82 8 1371-8
Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure.
Khandelwal N, James LP, Sanders C, Larson AM, Lee WM Hepatology (Baltimore, Md.) 2010 Nov
The case for limiting acetaminophen-related deaths: smaller doses and unbundling the opioid-acetaminophen compounds.
Lee WM Clinical pharmacology and therapeutics 2010 Sep 88 3 289-92
A prospective study of the rate of progression in compensated, histologically advanced chronic hepatitis C.
Dienstag JL, Ghany MG, Morgan TR, Di Bisceglie AM, Bonkovsky HL, Kim HY, Seeff LB, Szabo G, Wright EC, Sterling RK, Everson GT, Lindsay KL, Lee WM, Lok AS, Morishima C, Stoddard AM, Everhart JE Hepatology (Baltimore, Md.) 2011 Aug 54 2 396-405
Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure.
Khandelwal N, James LP, Sanders C, Larson AM, Lee WM Hepatology (Baltimore, Md.) 2011 Feb 53 2 567-76
Extended treatment with lamivudine and adefovir dipivoxil in chronic hepatitis B patients with lamivudine resistance.
Perrillo RP, Hann HW, Schiff E, Mutimer D, Willems B, Leung N, Lee WM, Dixon S, Woessner M, Brosgart CL, Condreay LD, Gardner SD Hepatology international 2011 Jun 5 2 654-63
Maintenance peginterferon therapy and other factors associated with hepatocellular carcinoma in patients with advanced hepatitis C.
Lok AS, Everhart JE, Wright EC, Di Bisceglie AM, Kim HY, Sterling RK, Everson GT, Lindsay KL, Lee WM, Bonkovsky HL, Dienstag JL, Ghany MG, Morishima C, Morgan TR Gastroenterology 2011 Mar 140 3 840-9; quiz e12
Update of chronic hepatitis B.
Yuan H, Lee WM Current opinion in gastroenterology 2011 May 27 3 217-23
Development and progression of portal hypertensive gastropathy in patients with chronic hepatitis C.
Fontana RJ, Sanyal AJ, Ghany MG, Bonkovsky HL, Morgan TR, Litman HJ, Reid AE, Lee WM, Naishadham D The American journal of gastroenterology 2011 May 106 5 884-93
Minimal Effects of Acute Liver Injury/Acute Liver Failure on Hemostasis as Assessed by Thromboelastography.
Todd Stravitz R, Lisman T, Luketic VA, Sterling RK, Puri P, Fuchs M, Ibrahim A, Lee WM, Sanyal AJ Journal of hepatology 2011 May
Hepatitis B virus genotype G: Prevalence and impact in patients co-infected with human immunodeficiency virus.
Dao DY, Balko J, Attar N, Neak E, Yuan HJ, Lee WM, Jain MK Journal of medical virology 2011 Sep 83 9 1551-8
IgG3 Is the Dominant Subtype of Anti-isoniazid Antibodies in Patients with Isoniazid-Induced Liver Failure.
Metushi IG, Lee WM, Uetrecht J Chemical research in toxicology 2014 May 27 5 738-40
Random forest classification of etiologies for an orphan disease.
Speiser JL, Durkalski VL, Lee WM Statistics in medicine 2014 Nov
Comparative analysis of portal hepatic infiltrating leukocytes in acute drug-induced liver injury, idiopathic autoimmune and viral hepatitis.
Foureau DM, Walling TL, Maddukuri V, Anderson W, Culbreath K, Kleiner DE, Ahrens WA, Jacobs C, Watkins PG, Fontana RJ, Chalasani N, Talwalkar J, Lee WM, Stolz A, Serrano J, Bonkovsky HL Clinical and experimental immunology 2014 Nov
Low SVR Rates in Clinical Practice for Treating Genotype 1 Chronic Hepatitis C with Protease Inhibitors Boceprevir and Telaprevir.
Dubin PH, Sclair SN, Rico R, Boehme AK, Chen EY, Martin P, Lee WM Digestive diseases and sciences 2014 Oct
Therapeutic hypothermia in acute liver failure: A multi-center retrospective cohort analysis.
Karvellas CJ, Stravitz RT, Battenhouse H, Lee WM, Schilsky ML Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2014 Oct
Malignant Infiltration of the Liver Presenting as Acute Liver Failure.
Rich NE, Sanders C, Hughes RS, Fontana RJ, Stravitz RT, Fix O, Han SH, Naugler WE, Zaman A, Lee WM Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2014 Sep
Procalcitonin Identifies Cell Injury, Not Bacterial Infection, in Acute Liver Failure.
Rule JA, Hynan LS, Attar N, Sanders C, Korzun WJ, Lee WM PloS one 2015 10 9 e0138566
Acute liver failure: A curable disease by 2024?
Bernal W, Lee WM, Wendon J, Larsen FS, Williams R Journal of hepatology 2015 Apr 62 1S S112-S120
Diabetes and prediabetes in patients with hepatitis B residing in North America.
Khalili M, Lombardero M, Chung RT, Terrault NA, Ghany MG, Kim WR, Lau D, Lisker-Melman M, Sanyal A, Lok AS Hepatology (Baltimore, Md.) 2015 Aug
Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity.
Hayashi PH, Fontana RJ, Chalasani NP, Stolz AA, Talwalker JA, Navarro VJ, Lee WM, Davern TJ, Kleiner DE, Gu J, Hoofnagle JH Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2015 Feb
Risk Factors, Clinical Presentation, and Outcomes in Overdose With Acetaminophen Alone or With Combination Products: Results From the Acute Liver Failure Study Group.
Serper M, Wolf MS, Parikh NA, Tillman H, Lee WM, Ganger DR Journal of clinical gastroenterology 2015 Jul
Circulating Levels of Soluble Rage and Rage-Ligands in Patients with Acute Liver Failure.
Basta G, Del Turco S, Navarra T, Lee WM Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2015 Mar
Development of a Model to Predict Transplant-free Survival of Patients with Acute Liver Failure.
Koch DG, Tillman H, Durkalski V, Lee WM, Reuben A Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2016 Apr
The role of hepatitis E virus infection in Adult Americans with acute liver failure.
Fontana RJ, Engle RE, Scaglione S, Araya V, Shaikh O, Tillman H, Attar N, Purcell RH, Lee WM Hepatology (Baltimore, Md.) 2016 May
Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure.
Karvellas CJ, Speiser JL, Tremblay M, Lee WM, Rose CF Hepatology (Baltimore, Md.) 2016 Nov
Corrigendum: Clinical Features and Outcomes of Complementary and Alternative Medicine Induced Acute Liver Failure and Injury.
Hillman L, Gottfried M, Whitsett M, Rakela J, Schilsky M, Lee WM, Ganger D The American journal of gastroenterology 2016 Oct 111 10 1504
The Natural History of Severe Acute Liver Injury.
Koch DG, Speiser JL, Durkalski V, Fontana RJ, Davern T, McGuire B, Stravitz RT, Larson AM, Liou I, Fix O, Schilsky ML, McCashland T, Hay JE, Murray N, Shaikh OS, Ganger D, Zaman A, Han SB, Chung RT, Brown RS, Munoz S, Reddy KR, Rossaro L, Satyanarayana R, Hanje AJ, Olson J, Subramanian RM, Karvellas C, Hameed B, Sherker AH, Lee WM, Reuben A The American journal of gastroenterology 2017 Apr
Heat Stroke Leading to Acute Liver Injury & Failure: A Case Series from the Acute Liver Failure Study Group.
Davis BC, Tillman H, Chung RT, Stravitz RT, Reddy KR, Fontana RJ, McGuire B, Davern T, Lee WM Liver international : official journal of the International Association for the Study of the Liver 2017 Jan
Elbasvir/Grazoprevir for Patients With Hepatitis C Virus Infection and Inherited Blood Disorders: A Phase III Study.
Hézode C, Colombo M, Bourlière M, Spengler U, Ben-Ari Z, Strasser SI, Lee WM, Morgan L, Qiu J, Hwang P, Robertson M, Nguyen BY, Barr E, Wahl J, Haber B, Chase R, Talwani R, Di Marco V Hepatology (Baltimore, Md.) 2017 Mar
NAC improves transplant free survival in non-APAP Acute Liver Failure
WM Lee, et al. Gastroenterology September 2009 7 856-864
- Relationship Between Metabolic Syndrome, Alanine Aminotransferase Levels, and Liver Disease Severity in a Multiethnic North American Cohort With Chronic Hepatitis B.
- Hepatitis B, Hepatitis C
- Drug-induced hepatotoxicity
- Acute liver failure
- Liver Disease
- Liver Transplant Medicine
- Liver Cancer
Q&A by Dr. Lee
Articles by Dr. Lee
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