Mark Agostini, M.D.

Director, Epilepsy Monitoring Unit, Parkland Health & Hospital System

  • Distinguished Teaching Professor
  • Neurology
  • Epilepsy & Seizures


Mark Agostini, M.D., is a Professor of Neurology at UT Southwestern Medical Center. He specializes in the care of patients with epilepsy.

Dr. Agostini received his medical degree at Harvard Medical School and completed his neurology residency at Massachusetts General Hospital, a teaching affiliate of Harvard Medical School. He completed a fellowship in neurology at the UCLA School of Medicine, as well as a fellowship in clinical neurophysiology at the Instituto Scientifico San Raffaela Hospital in Milan, Italy.

Dr. Agostini is active in clinical research as well as patient care. Among other projects, he was the principal investigator for the drug lacosamide (sold under the brand name Vimpat), which works in combination with other medications to help control seizures.

He has been named a Super Doctor by Texas Monthly and a Best Doctor by D Magazine. He is board certified by the American Board of Psychiatry and Neurology. He has received several teaching awards from UT Southwestern medical students and neurology residents.

Meet Dr. Agostini

When Mark Agostini, M.D., treats epilepsy patients at UT Southwestern Medical Center, he lives by the words of Winston Churchill: Never, never, never give up.

"We cure seizures.”

He relentlessly tracks down the cause of patients’ seizures and finds the treatment that works for them, with one goal in mind: stopping the seizures.

Each epilepsy patient is unique. What works for some won’t work for others, he says. As a result, each patient presents a challenge that requires the skills of a neurology specialist.

“We are relentless. We just don’t give up,” says Dr. Agostini, a graduate of Harvard Medical School.

Finding the right treatment means balancing quality of life, but the first step is always aimed at stopping the seizures. Dr. Agostini and the epilepsy team at UT Southwestern have access to the latest technologies and treatments to help find the answer. This includes UT Southwestern’s Epilepsy Monitoring Unit, which allows Dr. Agostini to see a patient’s seizure firsthand.

A researcher as well as a clinician, Dr. Agostini also is involved in experimental therapies such as intracranial stimulators and experimental anti-seizure medications that are in clinical trials. In several cases, his patients have benefited directly from this research. He was the principal investigator for the drug lacosamide (sold under the brand name Vimpat), which works in combination with other medications to help control seizures. Each anti-seizure medication brought to FDA approval offers a patient a chance to become seizure-free, Dr. Agostini says.

Dr. Agostini’s epilepsy patients have complex medical problems. When other doctors are needed, Dr. Agostini can rely on a multidisciplinary team that includes neuroradiologists, neuropsychologists, and neurosurgeons. Not many medical centers can offer that.

Working together, Dr. Agostini and the UTSW team achieve his ultimate goal as a physician treating epilepsy patients: “We give people their life back.”

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Education & Training
  • Internship - Massachusetts General Hospital (1989-1990), Medicine
  • Residency - Massachusetts General Hospital (1990-1993), Neurology
  • Fellowship - Instituto Scientifico San Raffaela Hospital (1993-1995), Neurophysiology
  • Medical School - Harvard Medical School (1985-1989)
  • Fellowship - UCLA (1995-1997), Epilepsy/eeg
Professional Associations & Affiliations
  • American Board of Clinical Neurophysiology
  • American Board of Registration of Electroencephalographic and evoked potential Technologists
  • Professional Advisory Board Epilepsy Foundation, Greater North Texas
Honors & Awards
  • Outstanding Faculty Teaching Award 2000, UT Southwestern
  • Outstanding Resident Teaching Award 1997, UCLA
  • Glaxo Young Investigator Award 1996
  • Merritt-Putnam Award 1995
  • Topscholar Award 1996
Books & Publications

Clinical Focus

  • Epilepsy & Seizures

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Q&A by Dr. Agostini