Clinical Heart and Vascular Center
What are clinical trials?
Clinical research trials are studies to find out more information about the body. Some clinical trials review the impact of certain medications or medical devices. Other trials are only observational and do not require any treatment. Clinical trials help guide the future of medicine to ensure we are providing the right treatment for certain diseases or prevention.
Why should I participate?
The future of medicine depends on data points and knowledge gained from clinical trials. You can make a difference in the health care of others and possibly improve your own health along the way. Each clinical trial is different and includes various procedures with risks and benefits. Speaking to the research team can help you decide if it is right for you.
What can I expect?
Volunteers can expect to discuss the study outline over the phone to find out if it is a good match. If the study is a good fit, you will be asked to come in to complete an in-person screening visit with informed consent to review procedures, interventions, risks, and benefits.
How do I get involved?
Review the potential studies below and contact a coordinator for more information if you're interested.
Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Clearance (HIPAC) Trial
Having high blood pressure (hypertension) in middle and early old age increases the risk of Alzheimer's disease (AD) and other types of dementia later in life. The study is to determine if lowering blood pressure with medication can reduce brain damage from high blood pressure and amyloid in the brain. Amyloid is a substance known to be high in the brain of older adults with dementia. We will recruit 80 older adults with high blood pressure.
- We are seeking participants between the ages of 55-79 years old with high blood pressure.
- Participants should not have a history of stroke or other cerebrovascular disease, clinical diagnosis of dementia or other neurodegenerative diseases, traumatic brain injury, major or unstable heart disease, chronic kidney disease, neurological and other severe medical conditions, history of drug or alcohol abuse within the last two years, uncontrolled diabetes (HgbA1C >7.5%), regular cigarette smoking within the last year, having a pacemaker or any other metallic devices, or anticipate pregnancy.
After passing screening, you will visit our office 3-4 times to complete a physical exam, blood draw, paper and pencil tests, ultrasound test, magnetic resonance imaging (MRI), etc.
During the treatment phase, we will provide you with high blood pressure drugs to treat your high blood pressure if you have it. Your health condition will be monitored closely.
We will repeat the same tests in the baseline phase after 12 months.
Preventing Metabolic Side Effects of Thiazide Diuretics with KMgCitrate
The Hypertension Section, Cardiology Division at the University of Texas Southwestern Medical Center at Dallas is conducting research to compare the effects of 2 different types of potassium supplements on patients taking a diuretic called chlorthalidone for treatment of high blood pressure. Participants will receive a health examination and blood tests at no charge. Study medication is also provided at no cost to the participating subjects.
The time required for participation in this study is 4-5 months. There will be compensation for each subject who participates in the study. We are looking for patients with treated or untreated blood pressure less than 160/100.
We are seeking individuals who have no other chronic medical problems such as diabetes, kidney disease, heart or liver disease, moderate or severe acid reflux disease, or chronic diarrhea. If you are taking BP medications, you will stop them and be put on chlorthalidone. You will have scheduled follow-up visits during the study.
Preventing Hypertension and Sympathetic Overactivation by Targeting Phosphate
The Hypertension Section, Cardiology Division at the University of Texas Southwestern Medical Center at Dallas is conducting research to study the effects of phosphate content in a typical American diet and the nerve activity that controls blood pressure in healthy subjects. Our interests are especially inorganic phosphates major in food preservatives, flavor enhancers, and food coloring, which are a large part of the typical American diet.
We are looking for healthy males or females between the ages of 18-80 years old without a history of diabetes mellitus, liver disease, heart problems, hypertension, weight over 220 lbs, smoking, or pregnancy. You will receive a health exam, blood testing, meals, and snacks at no cost, along with compensation.
By taking part you will help us determine whether the phosphate content in a typical American diet induces sustained increase in blood pressure and nerve activity. This may lead to changes in food labeling and more effective strategy in reducing the global burden of hypertension.